ZEXIPAG 400 Tablet 10's
Key Information
Generic Name
Generic Name Selexipag 400 mcg
Manufacturer
Cipla Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
ZEXIPAG 400 TABLET contains Selexipag, which belongs to the group of medicines known as Prostacyclin Receptor Agonists. It is used for the long-term management of Pulmonary Arterial Hypertension (PAH - a condition with increased pressure due to the narrowing of blood vessels supplying the lungs from the heart lungs) in adults. The symptoms of PAH may include dizziness, tiredness, shortness of breath, swelling in the ankles and legs, chest pain, heart failure, etc. ZEXIPAG 400 TABLET is not recommended for use in patients with coronary heart disease (poor blood supply to heart muscles, unstable angina (chest pain), weak heart (decompensated heart failure), a history of heart attack within the past 6 months, congenital or acquired heart valve disease, severe arrhythmias (irregular heartbeat). ZEXIPAG 400 TABLET should be taken with caution in patients with narrowing of the pulmonary vein, a condition called pulmonary venous-occlusive disease, severe liver disease, severe kidney disease, low blood pressure (hypotension) with dizziness and hyperthyroidism. ZEXIPAG 400 TABLET is generally not recommended for use by pregnant women, breastfeeding mothers and children less than 18 years of age. ZEXIPAG 400 TABLET is also not recommended for use in children under the age of 18 years. ZEXIPAG 400 TABLET should be used with caution in patients above 75 years of age. The
Uses
OF ZEXIPAG 400 TABLET Manage Pulmonary arterial hypertension (PAH)
How It Works
ZEXIPAG 400 TABLET works similarly to a natural substance present in our body (Prostacyclin) by widening the pulmonary arteries and reducing their hardness. Doing so makes it easier for the heart to pump blood to the lungs effectively. It also decreases pressure in pulmonary arteries, hence reducing the symptoms of pulmonary arterial hypertension and slowing down the progression of the disease. The metabolite released by ZEXIPAG 400 TABLET has vasodilatory, anti-proliferative and anti-fibrotic effects.
Directions for Use
Take ZEXIPAG 400 TABLET as advised by your physician. Swallow the medicine with a glass of water and do not crush or chew the medicine. Your management dose and duration will be decided by your physician depending on your age, body weight and disease condition.
Side Effects
taking ZEXIPAG 400 TABLET may include headache, flushing (reddening of the face), nausea, vomiting, diarrhoea, jaw pain, muscle pain, joint pain, nasopharyngitis (stuffy nose), anaemia, weight loss, rashes, stomach pain, hypotension (low blood pressure), hyperthyroidism, tachycardia (increased heart rate), etc. Consult your doctor if any of the side effects get worse. USES OF ZEXIPAG 400 TABLET Manage Pulmonary arterial hypertension (PAH) HOW ZEXIPAG 400 TABLET WORKSZEXIPAG 400 TABLET works similarly to a natural substance present in our body (Prostacyclin) by widening the pulmonary arteries and reducing their hardness. Doing so makes it easier for the heart to pump blood to the lungs effectively. It also decreases pressure in pulmonary arteries, hence reducing the symptoms of pulmonary arterial hypertension and slowing down the progression of the disease. The metabolite released by ZEXIPAG 400 TABLET has vasodilatory, anti-proliferative and anti-fibrotic effects. DIRECTIONS FOR USETake ZEXIPAG 400 TABLET as advised by your physician. Swallow the medicine with a glass of water and do not crush or chew the medicine. Your management dose and duration will be decided by your physician depending on your age, body weight and disease condition. SIDE EFFECTS OF ZEXIPAG 400 TABLETCOMMON headache flushing (reddening of the face) nausea and vomiting, diarrhoea jaw pain, pain in muscles and joints leg pain nasopharyngitis (stuffy nose) anaemia (low red blood cell levels) hyperthyroidism (overactive thyroid gland) reduced appetite weight loss hypotension (low blood pressure) stomach pain affects the blood test results, including the blood cell counts or thyroid function test rashes and hives may cause a burning or stinging sensation and skin redness UNCOMMON tachycardia (increased heart rate)
Warnings & Precautions
& PRECAUTIONSPREGNANCYZEXIPAG 400 TABLET is generally not recommended for use in pregnant women. Consult your doctor before taking it. BREASTFEEDINGZEXIPAG 400 TABLET is generally not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Consult your doctor before taking it. DRIVING AND USING MACHINESZEXIPAG 400 TABLET causes headaches and low blood pressure, which can affect your ability to drive and operate machines. Consult your doctor for advice. KIDNEYZEXIPAG 400 TABLET should be taken with caution in patients with severe kidney disease. Consult your doctor before taking ZEXIPAG 400 TABLET. LIVERZEXIPAG 400 TABLET should be used with caution in patients with severe liver disease. Consult your doctor before taking ZEXIPAG 400 TABLET. ALLERGYDo not take ZEXIPAG 400 TABLET if you are allergic to selexipag or other ingredients in this medicine. LUNGSZEXIPAG 400 TABLET should be taken with caution in patients with lung diseases such as narrowing of the pulmonary veins, a condition called pulmonary venous-occlusive disease. Consult your doctor before taking ZEXIPAG 400 TABLET. HEART DISEASEGBNKEYWORD] is not recommended for use in patients with coronary heart disease (poor blood supply to heart muscles) or unstable angina (chest pain), weak heart (decompensated heart failure, a history of heart attack within the past 6 months, congenital or acquired heart valve disease, severe arrhythmias (irregular heartbeat). It should be used with caution in patients suffering from hypotension (low blood pressure). Consult your doctor before taking ZEXIPAG 400 TABLET. OTHERSZEXIPAG 400 TABLET is not indicated for use if you: have suffered a stroke within the past 3 months have a transient ischemic stroke Before taking ZEXIPAG 400 TABLET, inform your doctor if you: have a hyperactive thyroid gland have recently suffered from severe diarrhoea or vomiting or significant blood loss Use in paediatrics: ZEXIPAG 400 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it. Use in geriatrics: ZEXIPAG 400 TABLET should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking it.
Drug Interactions
SA. Drug-Drug interactions: Before taking ZEXIPAG 400 TABLET, inform your physician if you are taking any of the following medicine: gemfibrozil (a medicine used to lower the level of fats in the blood) clopidogrel (a medicine used for managing blood clots) deferasirox (a medicine used to manage iron overload) carbamazepine (a medicine used in the management of fits & seizures, nerve pain or to help control serious mood disorders when some other medicines do not work) teriflunomide (a medicine used for relapsing-remitting multiple sclerosis) phenytoin, valproic acid (a medicine used for the management of fits & seizures) probenecid (a medicine used in the management of gout) fluconazole (a medicine used for the management of fungal infections) rifampicin or rifapentine (a medicine used for the management of tuberculosis) lopinavir, ritonavir (medicines used for the management of HIV infections) Overdosage: If you or anyone else have accidentally taken too much of ZEXIPAG 400 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are mild transient nausea SYNOPSIS Drug : Selexipag Pharmacological Category : Prostacyclin Receptor Agonist Therapeutic Indication : Manages Pulmonary arterial hypertension (PAH) Dosage Forms : Tablet MORE INFORMATION Keep ZEXIPAG 400 TABLET out of reach from children Store at room temperature
Article Information
Written By
DETAILSWritten By Dr. Dhivakaran R, BDS
Medical Content Writer
Last Updated
30 Sep 2022