STAURINZ 25mg Soft Gelatin Capsule 28's
Key Information
Generic Name
Generic Name Midostaurin 25 mg
Manufacturer
Dr. Reddy's Laboratories Ltd
Variant
28 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT STAURINZ 25MG SOFT GELATIN CAPSULESTAURINZ 25MG SOFT GELATIN CAPSULE is used to manage acute myeloid leukaemia (AML) in adults who have a defect in a gene called FLT3. It is also used in adults to manage aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL). These are disorders in which the body produces too many mast cells (a type of white blood cell). STAURINZ 25MG SOFT GELATIN CAPSULE contains Midostaurin which belongs to the group of medicines called Protein kinase inhibitors which blocks the action of some enzymes (kinases) in the cancerous cells and stops their division and growth. Your doctor will perform regular blood tests during treatment with STAURINZ 25MG SOFT GELATIN CAPSULE in order to monitor the amount of blood cells (white blood cells, red blood cells and platelets) and electrolytes (e.g. calcium, potassium, magnesium) in your body. Your heart and lung function will also be checked regularly. Before taking STAURINZ 25MG SOFT GELATIN CAPSULE, inform your doctor if you have any infections, heart or lung problems. It should be used with caution in patients with liver problems due to alcohol to manage the risk of liver damage. STAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in pregnant and breastfeeding women. STAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in children and adolescents less than 18 years of age. The most common
Uses
OF STAURINZ 25MG SOFT GELATIN CAPSULEManagement of blood cancer and other blood disorders like: Acute myeloid leukaemia (AML) in adults who have a defect in a gene called FLT3. Aggressive systemic mastocytosis (ASM) Systemic mastocytosis with associated haematological neoplasm (SM-AHN) Mast cell leukaemia (MCL)
How It Works
STAURINZ 25MG SOFT GELATIN CAPSULE contains Midostaurin which works by blocking certain proteins (called kinases) that are involved in the growth and survival of cancer cells. Specifically, it targets abnormal proteins in blood cells that lead to uncontrolled cell growth, as seen in some types of leukemia. By inhibiting these proteins, midostaurin helps to slow down or stop the growth of cancer cells.
Directions for Use
Take STAURINZ 25MG SOFT GELATIN CAPSULE with food or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the condition.
Side Effects
taking STAURINZ 25MG SOFT GELATIN CAPSULE include red or purple, flat, pinhead spots under the skin, problems falling asleep, headache, dizziness, shortness of breath, respiratory infections, mouth sores, nausea, vomiting, upper abdominal pain, piles, excessive sweating, thirst, back pain, joint pain, neck pain, muscle pain, high urine output, dark urine, dry flushed skin, abnormal heart rhythm, swelling of the eyelid and weight gain. Consult your doctor if any symptoms worsens. USES OF STAURINZ 25MG SOFT GELATIN CAPSULEManagement of blood cancer and other blood disorders like: Acute myeloid leukaemia (AML) in adults who have a defect in a gene called FLT3. Aggressive systemic mastocytosis (ASM) Systemic mastocytosis with associated haematological neoplasm (SM-AHN) Mast cell leukaemia (MCL) HOW STAURINZ 25MG SOFT GELATIN CAPSULE WORKSSTAURINZ 25MG SOFT GELATIN CAPSULE contains Midostaurin which works by blocking certain proteins (called kinases) that are involved in the growth and survival of cancer cells. Specifically, it targets abnormal proteins in blood cells that lead to uncontrolled cell growth, as seen in some types of leukemia. By inhibiting these proteins, midostaurin helps to slow down or stop the growth of cancer cells. DIRECTIONS FOR USETake STAURINZ 25MG SOFT GELATIN CAPSULE with food or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the condition. SIDE EFFECTS OF STAURINZ 25MG SOFT GELATIN CAPSULECOMMON infection at catheter site red or purple, flat, pinhead spots under the skin (petechiae) problems falling asleep (insomnia) headache, dizziness, fainting shortness of breath, nose bleeds, throat pain, runny nose, fever mouth sores (stomatitis) nausea, vomiting, upper abdominal pain haemorrhoids (piles), rectal pain and anal discomfort excessive sweating back pain, joint pain, neck pain, limb pains thirst, high urine output, dark urine, dry flushed skin muscle spasms, weakness and twiching abnormal heart rhythm bruising and bleeding (defect in blood clotting) hypocalcemia swelling of the eyelid eye pain, blurred vision, intolerance to light (keratitis) increased weight Stop taking STAURINZ 25MG SOFT GELATIN CAPSULE and contact your doctor immediately if you experience any of the following side effects: allergic reaction (swelling of the hands, feet, ankles, face, lips or throat which may cause trouble swallowing or breathing, an itchy, lumpy rash or nettle rash, runny nose) weakness, spontaneous bleeding or bruising, frequent infections with signs such as fever, chills, sore throat or mouth ulcers (signs of a low level of blood cells) fever, cough with or without mucus, chest pain, trouble breathing or shortness of breath (signs of non-infectious interstitial lung disease or pneumonitis) severe shortness of breath, laboured and unusually rapid breathing, dizziness, light-headedness, confusion and extreme tiredness (signs of acute respiratory distress syndrome) infections, fever, low blood pressure, decreased urination, rapid pulse, rapid breathing (signs of sepsis or neutropenic sepsis)
Warnings & Precautions
& PRECAUTIONSPREGNANCYContraindicatedSTAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in pregnant women as it can harm the unborn baby. Your doctor will ask you to take a pregnancy test before you start treatment to make sure you are not pregnant. You must use an effective method of contraception during and at least 4 months after you have stopped taking it. It also reduces fertility. Consult your doctor before taking STAURINZ 25MG SOFT GELATIN CAPSULE. BREASTFEEDINGContraindicatedSTAURINZ 25MG SOFT GELATIN CAPSULE is not recommended in breastfeeding women as it can harm the baby. You should not breast-feed during treatment with STAURINZ 25MG SOFT GELATIN CAPSULE and for at least 4 months after stopping the treatment. Consult your doctor before taking it. DRIVING AND USING MACHINESUse with CautionSTAURINZ 25MG SOFT GELATIN CAPSULE can cause dizziness and vertigo hence be cautious while driving or using heavy machines. ALLERGYContraindicatedDo not take STAURINZ 25MG SOFT GELATIN CAPSULE if you are allergic to Midostaurin or any other ingredients of this medicine. LUNGSUse with CautionSTAURINZ 25MG SOFT GELATIN CAPSULE should be used with caution in patients with lungs or breathing problems. Consult your doctor before taking it. HEART DISEASEUse with CautionSTAURINZ 25MG SOFT GELATIN CAPSULE should be used with caution in patients with heart disorders. Consult your doctor before taking it. USE IN PEDIATRICSContraindicatedSTAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in children and adolescents less than 18 years of age who are also receiving other chemotherapy, because it could cause a severe reduction of certain types of blood cells. Consult your child’s doctor for advice. USE IN GERIATRICSUse with CautionSTAURINZ 25MG SOFT GELATIN CAPSULE should be used with caution in elderly patients. Consult your doctor before taking it. OTHERSBefore taking STAURINZ 25MG SOFT GELATIN CAPSULE, inform your doctor if you: have any infections
Drug Interactions
SA. Drug-Drug interactions: Before taking STAURINZ 25MG SOFT GELATIN CAPSULE, inform your doctor if you are taking any of the following medicines: Anti tuberculosis (Ex. Rifampicin) Anti epilepsy (Ex. carbamazepine or phenytoin) Anti-cancer (Ex. Enzalutamide) Antidepressants (Ex. St. John’s Wort, nefazodone or bupropion) Anti-infective such as ketoconazole or clarithromycin anti-HIV, such as ritonavir or efavirenz some medicines used to control levels of fat in your blood, such as atorvastatin or rosuvastatin muscle relaxants like tizanidine and chlorzoxazone Overdosage: If you or anyone else accidentally takes too much of STAURINZ 25MG SOFT GELATIN CAPSULE, consult your doctor immediately or visit the nearby hospital. SYNOPSIS Drug : Midostaurin Pharmacological Category : Protein kinase inhibitors Therapeutic Indication : Acute myeloid leukaemia (AML), aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL) Dosage Forms : Capsule MORE INFORMATIONSTORAGE Keep STAURINZ 25MG SOFT GELATIN CAPSULE out of reach of children Store below 25°C
Frequently Asked Questions
Common questions and answers about STAURINZ 25mg Soft Gelatin Capsule 28's.
What does STAURINZ 25MG SOFT GELATIN CAPSULE contain?
STAURINZ 25MG SOFT GELATIN CAPSULE contains Midostaurin which belongs to the group of medicines called Protein kinase inhibitors.
What is the use of STAURINZ 25MG SOFT GELATIN CAPSULE?
STAURINZ 25MG SOFT GELATIN CAPSULE is used to manage acute myeloid leukaemia (AML) in adults who have a defect in a gene called FLT3. It is also used in adults to manage aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN), or mast cell leukaemia (MCL). These are disorders in which the body produces too many mast cells (a type of white blood cell).
Do we need to perform any tests before starting the treatment?
Your doctor will perform regular blood tests during treatment with STAURINZ 25MG SOFT GELATIN CAPSULE in order to monitor the amount of blood cells (white blood cells, red blood cells and platelets) and electrolytes (e.g. calcium, potassium, magnesium) in your body. Your heart and lung function will also be checked regularly.
What are the precautions to be followed before taking STAURINZ 25MG SOFT GELATIN CAPSULE?
Before taking STAURINZ 25MG SOFT GELATIN CAPSULE, inform your doctor if you have any infections, heart or lung problems. It should be used with caution in patients with liver problems due to alcohol to manage the risk of liver damage.
Can STAURINZ 25MG SOFT GELATIN CAPSULE be used during pregnancy?
STAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in pregnant women as it can harm the unborn baby. Your doctor will ask you to take a pregnancy test before you start treatment to make sure you are not pregnant. You must use an effective method of contraception during and at least 4 months after you have stopped taking it. It also reduces fertility. Consult your doctor before taking STAURINZ 25MG SOFT GELATIN CAPSULE.
Can STAURINZ 25MG SOFT GELATIN CAPSULE be used in children?
STAURINZ 25MG SOFT GELATIN CAPSULE is not recommended for use in children and adolescents less than 18 years of age.
What are the side effects of taking STAURINZ 25MG SOFT GELATIN CAPSULE?
The most common side effects of taking STAURINZ 25MG SOFT GELATIN CAPSULE include red or purple, flat, pinhead spots under the skin, problems falling asleep, headache, dizziness, shortness of breath, respiratory infections, mouth sores, nausea, vomiting, upper abdominal pain, piles, excessive sweating, thirst, back pain, joint pain, neck pain, muscle pain, high urine output, dark urine, dry flushed skin, abnormal heart rhythm, swelling of the eyelid and weight gain. Consult your doctor if any symptoms worsen.
How does STAURINZ 25MG SOFT GELATIN CAPSULE work?
STAURINZ 25MG SOFT GELATIN CAPSULE contains Midostaurin which works by blocking certain proteins (called kinases) that are involved in the growth and survival of cancer cells. Specifically, it targets abnormal proteins in blood cells that lead to uncontrolled cell growth, as seen in some types of leukemia. By inhibiting these proteins, midostaurin helps to slow down or stop the growth of cancer cells.
Article Information
Written By
DETAILS Written By Srilekha. R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
14 Sep 2024