SORAFENAT 200mg Tablet 120's
Key Information
Generic Name
Generic Name Sorafenib 200 mg
Manufacturer
Natco Pharma Ltd
Variant
120 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
SORAFENAT 200MG TABLET contains Sorafenib which belongs to the group of medicines called Multikinase inhibitors. It is used to manage liver cancer (hepatocellular carcinoma), and kidney cancer (advanced renal cell carcinoma) at an advanced stage when standard therapy has not helped to stop the disease or con
Uses
OF SORAFENAT 200MG TABLET Manage liver cancer (hepatocellular carcinoma) Manage kidney cancer (advanced renal cell carcinoma) Manage thyroid cancer (differentiated thyroid carcinoma)
How It Works
SORAFENAT 200MG TABLET is an oral multi-kinase inhibitor which blocks tumour cell growth. It targets several enzymes on the surface of cancer cells and also targets within the cell. Several of these targets are thought to be involved in angiogenesis (making of blood vessels). SORAFENAT 200MG TABLET works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing.
Directions for Use
Take SORAFENAT 200MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking SORAFENAT 200MG TABLET are nausea, diarrhoea, vomiting, constipation, weakness or tiredness, hair loss (alopecia) or rash. Contact your physician if any of the symptoms worsen. USES OF SORAFENAT 200MG TABLET Manage liver cancer (hepatocellular carcinoma) Manage kidney cancer (advanced renal cell carcinoma) Manage thyroid cancer (differentiated thyroid carcinoma) HOW SORAFENAT 200MG TABLET WORKSSORAFENAT 200MG TABLET is an oral multi-kinase inhibitor which blocks tumour cell growth. It targets several enzymes on the surface of cancer cells and also targets within the cell. Several of these targets are thought to be involved in angiogenesis (making of blood vessels). SORAFENAT 200MG TABLET works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing. DIRECTIONS FOR USETake SORAFENAT 200MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF SORAFENAT 200MG TABLETCOMMON nausea diarrhoea vomiting constipation abdominal pain weakness or tiredness mouth pain, pain in bones, and tumour pain hair loss (alopecia) headache itching or rash redness or painful palms and soles bleeding in the brain, lungs or airways, stomach and intestine high blood pressure infections loss of appetite joint pain (arthralgia) fever weight loss flu-like illness indigestion difficulty swallowing inflamed or dry mouth tongue pain hypocalcaemia (decrease in calcium levels in the blood) low blood sugar levels hypokalaemia (decrease in potassium levels) muscle pain tingling and numbness sensations in fingers and toes erection problems (impotence) change in voice acne inflamed, dry, scaly skin or shedding kidney failure decrease in white blood cells (leukopenia) decrease in red blood cells (anaemia) decrease in platelet count (thrombocytopenia) inflammation of hair follicles hypothyroidism hyponatremia (low sodium levels in the blood) change in sense of taste redness of the face and other areas of the skin (flushing) runny nose heartburn skin cancer thickening of the skin muscle spasms ringing in the ear UNCOMMON gastritis, abdominal pain caused by pancreatitis, inflammation of the gall bladder and/or bile ducts yellowish discolouration of skin or white of the eyes (jaundice) caused by high levels of bile pigments (hyperbilirubinemia) allergic reactions like skin reactions and hives dehydration enlargement of breasts breathing difficulty eczema hyperthyroidism multiple skin eruptions (erythema multiforme) reversible posterior leukoencephalopathy (reversible swelling in the rear part of the brain that can be associated with headache, change in consciousness, fits and visual loss) RARE sunburn-like rash or severe radiation recall dermatitis may occur in patients with a history of radiotherapy management abnormal heart rhythm (QT prolongation) nephrotic syndrome (damage to the kidney causing leakage of proteins) inflammation of the vessels in the skin causing skin rashes allergic reaction such as swelling of the face, tongue causing difficulty in breathing or swallowing (angioedema) serious reactions of the skin and/or mucous membranes include painful blisters, fever, and extensive detachment of the skin (Stevens-Johnson syndrome and toxic epidermal necrolysis) breakdown of muscles (rhabdomyolysis) causing kidney problems inflammation of the vessels in the skin which may result in skin rash (leucocytoclastic vasculitis) Stop taking SORAFENAT 200MG TABLET and contact your physician immediately if you experience any of the following side effects: severe allergic reactions (such as blisters, hives, skin swelling, face or tongue, difficulty breathing or swallowing, etc.) symptoms of Tumour lysis syndrome (TLS) such as nausea, shortness of breath, irregular heartbeat, muscular cramps, seizure, clouding of urine and tiredness rashes and skin reactions especially on the hands and feet chest pain or heart problems such as heart attack perforation or holes in the stomach or the intestine severe bleeding which may also present as bloody vomit, brownish urine, red or black coloured stool, coughing up blood or blood clots, heavy menstrual bleeding, vaginal bleeding, bleeding from the nose etc. severe diarrhoea severe high blood pressure or liver injury
Warnings & Precautions
& PRECAUTIONSPREGNANCYContraindicatedSORAFENAT 200MG TABLET is not recommended for use during pregnancy or if you think you could become pregnant, use adequate contraception during management with this medicine. Consult your doctor before taking SORAFENAT 200MG TABLET. BREASTFEEDINGContraindicatedSORAFENAT 200MG TABLET is not recommended for use in breastfeeding women as it interferes with the growth of the developing baby. Consult your doctor before taking SORAFENAT 200MG TABLET. DRIVING AND USING MACHINESUse with CautionThere is no evidence that SORAFENAT 200MG TABLET will affect the ability to drive or operate machines. KIDNEYUse with CautionSORAFENAT 200MG TABLET should be used with caution in patients with poor kidney function. Consult your doctor before taking SORAFENAT 200MG TABLET. LIVERUse with CautionSORAFENAT 200MG TABLET should be used with caution in patients with severe liver disease. Consult your doctor before taking SORAFENAT 200MG TABLET. ALLERGYContraindicatedDo not take SORAFENAT 200MG TABLET if you are allergic to Sorafenib or any other ingredients of this medicine. LUNGSContraindicatedSORAFENAT 200MG TABLET is not recommended for use in patients with squamous cell lung cancer. Consult your doctor before taking SORAFENAT 200MG TABLET. HEART DISEASEUse with CautionSORAFENAT 200MG TABLET should be used with caution in patients with high blood pressure and heart diseases such as abnormal heart rhythm disorders called prolonged QT interval. Consult your doctor before taking SORAFENAT 200MG TABLET. USE IN PEDIATRICSConsult your doctorThe safety and efficacy of SORAFENAT 200MG TABLET in children and adolescents (below 18 years of age) have not yet been established. Consult child’s doctor for advice USE IN GERIATRICSUse with CautionSORAFENAT 200MG TABLET should be used with caution in elderly patients with kidney failure. Consult your doctor before taking SORAFENAT 200MG TABLET. OTHERSBefore taking SORAFENAT 200MG TABLET, inform your doctor if you have: aneurysm (enlargement or weakening of blood vessels) or tearing of blood vessel wall diabetes bleeding problems surgery, or recently had an operation perforation of the stomach and intestine low potassium, magnesium and calcium levels
Drug Interactions
SA. Drug-Drug interactions: Before taking SORAFENAT 200MG TABLET, inform your doctor if you are taking any of the following medicines: rifampicin, rifabutin, rifampin (used to manage tuberculosis) neomycin or other antibiotics (used to manage bacterial infections) St. john’s wort (used to manage depression) phenytoin, carbamazepine or phenobarbital (used to manage fits) dexamethasone (used to manage inflammation) warfarin or phenprocoumon, anticoagulants such as dabigatran (used to manage blood clots) doxorubicin, capecitabine, docetaxel, paclitaxel, gemcitabine, cisplatin and irinotecan (used to manage cancer) digoxin (used to manage heart failure) midazolam (used to manage seizures) dextromethorphan (used to manage cough) omeprazole (used to manage gastric ulcers) B. Drug - Food interactions: Do not take SORAFENAT 200MG TABLET with high fat meals, as this may make the medicine less effective. If you intend to have a high fat meal, take SORAFENAT 200MG TABLET at least 1 hour before or 2 hours after the meal. Consult your doctor for advice. Overdosage: If you or anyone else accidentally take too much of SORAFENAT 200MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are severe diarrhoea and skin reactions. SYNOPSIS Drug : Sorafenib Pharmacological Category : Multikinase inhibitors Therapeutic Indication : Liver Cancer, Kidney Cancer, Thyroid Cancer Dosage Forms : Tablet MORE INFORMATION Keep SORAFENAT 200MG TABLET out of the sight and reach of children. Store at room temperature
Frequently Asked Questions
Common questions and answers about SORAFENAT 200mg Tablet 120's.
How does SORAFENAT 200MG TABLET work?
SORAFENAT 200MG TABLET is an oral multi-kinase inhibitor which blocks tumour cell growth. It targets several enzymes on the surface of cancer cells and also targets within the cell. Several of these targets are thought to be involved in angiogenesis (making of blood vessels). SORAFENAT 200MG TABLET works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing.
Does SORAFENAT 200MG TABLET affects fertility?
Yes, SORAFENAT 200MG TABLET reduces fertility in both men and women. Consult your doctor before taking SORAFENAT 200MG TABLET if you want to father a child or if you are a woman with childbearing potential. Your doctor may recommend you to use effective contraceptive measures during management with SORAFENAT 200MG TABLET
What are the common side effects of taking SORAFENAT 200MG TABLET?
The most common side effects of taking SORAFENAT 200MG TABLET are nausea, diarrhoea, vomiting, constipation, feeling weak or tiredness, and hair loss (alopecia). Consult your physician if any of the symptoms worsen.
For how long should I need to take SORAFENAT 200MG TABLET?
If SORAFENAT 200MG TABLET is well tolerated, then you should continue taking it for the duration as suggested by the doctor. However, if you experience any unusual reactions which bothers you talk to your doctor for advice
Is SORAFENAT 200MG TABLET safe to use in patients with heart disease?
SORAFENAT 200MG TABLET should be used with caution in patients with high blood pressure and heart diseases such as abnormal heart rhythm disorders called prolonged QT interval. Consult your doctor before taking SORAFENAT 200MG TABLET
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
20 Mar 2023