Rokfos Infusion 1's
Key Information
Generic Name
Generic Name Zoledronic Acid 5 mg Also Known As: Zoledronate
Manufacturer
Cipla Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT ROKFOS INFUSIONROKFOS INFUSION contains Zoledronic Acid, which belongs to the group of medicines called Bisphosphonates. It is used to manage bone complications such as fractures and bone metastases (cancer that has spread from the original (primary) tumour to the bone) in adult patients and helps to reduce the amount of calcium in the blood in adult patients (tumour-induced hypercalcaemia (TIH)). Along with management with ROKFOS INFUSION, your doctor might ask you to make some lifestyle changes, such as eating a balanced diet rich in calcium and vitamin D. Prior to starting management with ROKFOS INFUSION, your doctor might want you to take some diagnostic tests to understand the existing condition. Before receiving ROKFOS INFUSION, inform your doctor if you have had or have pain, swelling or numbness of the jaw, a feeling of heaviness in the jaw or loosening of teeth, kidney disease, are having dental management, or are due to undergo dental surgery. ROKFOS INFUSION is not recommended for use in pregnant and breast-feeding women. ROKFOS INFUSION is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving ROKFOS INFUSION. The most common
Uses
OF ROKFOS INFUSIONUsed in adult patients to: Manage bone complications such as fractures and bone metastases Helps to reduce the amount of calcium in the blood (tumour-induced hypercalcaemia (TIH))
How It Works
ROKFOS INFUSION works by suppressing the activity of osteoclasts, cells that cause the destruction of bones. This strengthens the bones and minimizes the risk of fractures.
Directions for Use
ROKFOS INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ROKFOS INFUSION for you depending upon your age, body weight, and disease condition.
Side Effects
receiving ROKFOS INFUSION are headache, nausea, vomiting, loss of appetite, conjunctivitis, and anemia (a low number of red blood cells). Inform your doctor if any of the symptoms worsen. USES OF ROKFOS INFUSIONUsed in adult patients to: Manage bone complications such as fractures and bone metastases Helps to reduce the amount of calcium in the blood (tumour-induced hypercalcaemia (TIH)) HOW ROKFOS INFUSION WORKSROKFOS INFUSION works by suppressing the activity of osteoclasts, cells that cause the destruction of bones. This strengthens the bones and minimizes the risk of fractures. DIRECTIONS FOR USEROKFOS INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ROKFOS INFUSION for you depending upon your age, body weight, and disease condition. SIDE EFFECTS OF ROKFOS INFUSIONCOMMON Headache Flu-like symptoms such as fever, fatigue, weakness, drowsiness, chills, and bone, joint, or muscle pain Gastrointestinal reactions such as nausea, vomiting, and loss of appetite Conjunctivitis Low level of phosphate in the blood Low level of red blood cells (anemia) UNCOMMON Allergic reactions High or low blood pressure, chest pain Rash, itching, redness, and swelling at the infusion site Shortness of breath Dizziness, anxiety Sleep disturbances Taste disturbances Trembling Tingling or numbness of the hands or feet Diarrhea, constipation, and abdominal pain Dry mouth Weight gain Increased sweating Sleepiness Blurred vision, tearing of the eye, and eye sensitivity to light Sudden coldness with fainting, limpness, or collapse Difficulty breathing with wheezing or coughing Urticaria RARE Slow heartbeat Confusion Unusual fracture of the thigh bone (symptoms such as pain, weakness, or discomfort in the thigh, hip, or groin) Interstitial lung disease (inflammation of the tissue around the air sacs of the lungs) Joint swelling Painful redness and/or swelling of the eye Consult your doctor if you experience any of the following side effects after receiving ROKFOS INFUSION: Severe kidney impairment (signs include nausea, vomiting, fluid retention, and decreased or increased urination) Low levels of calcium in the blood (hypocalcaemia) (symptoms such as muscle cramps, dry skin, burning sensations, irregular heartbeat, seizures, spasms, and twitching (tetany)) Bone damage in the jaw (osteonecrosis) (symptoms such as pain in the mouth, teeth, and/or jaw, swelling or non-healing sores inside the mouth or jaw, discharge, numbness or feeling of heaviness in the jaw or loosening of a tooth) Irregular heart rhythm (atrial fibrillation) Severe allergic reaction (symptoms such as shortness of breath and swelling mainly of the face and throat)
Warnings & Precautions
& PRECAUTIONSPREGNANCYContraindicatedROKFOS INFUSION is not recommended for use by pregnant women. Consult your doctor before receiving ROKFOS INFUSION. BREASTFEEDINGContraindicatedROKFOS INFUSION is not recommended for use by breastfeeding women. Consult your doctor before receiving ROKFOS INFUSION. DRIVING AND USING MACHINESContraindicatedDo not drive or operate any machines if you feel drowsiness and sleepiness after receiving ROKFOS INFUSION. KIDNEYUse with CautionROKFOS INFUSION should be used with caution in patients with kidney problems. Consult your doctor before receiving ROKFOS INFUSION. ALLERGYContraindicatedDo not receive ROKFOS INFUSION if you are allergic to Zoledronic Acid, other bisphosphonates (such as alendronate), or any of the other ingredients of this medicine. USE IN PEDIATRICSContraindicatedROKFOS INFUSION is not recommended for use in children and adolescents (under 18 years of age). Consult the child’s doctor for advice. USE IN GERIATRICSUse with CautionROKFOS INFUSION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving ROKFOS INFUSION. OTHERSBefore receiving ROKFOS INFUSION, inform your doctor if you: Had or have pain, swelling, or numbness of the jaw, a feeling of heaviness in the jaw, or a loosening of teeth Are having dental management or are due to undergo dental surgery
Drug Interactions
SA. Drug-Drug interactions: Before receiving ROKFOS INFUSION, inform your doctor if you have received, are receiving, or are taking any of the following medicines: Aminoglycosides such as gentamicin Calcitonin Loop diuretics such as chlorthalidone and indapamide Other calcium-lowering medicines Anticancer agents like thalidomide Any other bisphosphonates, such as risedronate Anti-angiogenic medicines such as bevacizumab and axitinib Overdosage: ROKFOS INFUSION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, such as serum electrolyte abnormalities (Ex. abnormal levels of calcium, phosphorus, and magnesium) and/or changes in kidney function, including severe kidney impairment, consult your doctor immediately. SYNOPSIS Drug : Zoledronic Acid Pharmacological Category : Bisphosphonates Therapeutic Indication : To manage fractures and bone metastases, reduce the amount of calcium in the blood Dosage Forms : Injection, Infusion MORE INFORMATIONSTORAGE Keep out of reach of children Store ROKFOS INFUSION below 25°C. Do not freeze
Frequently Asked Questions
Common questions and answers about Rokfos Infusion 1's.
What precautions should be taken before using ROKFOS INFUSION?
Inform your doctor if you have any kidney problems, low calcium levels, or any other medical conditions. Ensure adequate hydration before the infusion. Calcium and vitamin D supplements may be recommended to prevent low calcium levels. Q. Can ROKFOS INFUSION interact with other medications? A: Yes, ROKFOS INFUSIONcan interact with medications such as aminoglycosides (which can also affect kidney function) and other drugs that may affect calcium levels. Always inform your doctor about all medications you are taking. Q. How should ROKFOS INFUSIONbe stored? A: ROKFOS INFUSION should be stored in a refrigerator (2-8°C) and protected from light. It should not be frozen. Q. What should I do if I experience side effects? A: Report any side effects to your healthcare provider. Immediate medical attention may be needed for severe reactions. Q. Is ROKFOS INFUSION safe for long-term use? A: Your doctor will evaluate the benefits and risks of long-term use based on your specific condition. Regular monitoring of kidney function and other parameters will be necessary during treatment. For any further questions or concerns, always consult your healthcare provider for personalized advice.
How long should I receive ROKFOS INFUSION?
ROKFOS INFUSION should be received in the dose and duration as advised by your doctor. The medicine takes around 6 months to show its maximum benefits for bones. However, in some cases, the doctor may suggest ROKFOS INFUSION for a longer duration. The exact duration will depend on the condition you are being managed for.
How is ROKFOS INFUSION administered?
ROKFOS INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of ROKFOS INFUSION for you depending upon your age, body weight, and disease condition.
What are the lifestyle changes I should follow while receiving ROKFOS INFUSION?
To get maximum benefit from this medicine, there are certain lifestyle changes that you must adhere to. Include some calcium- or vitamin-D-rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption, as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics, as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight, which in turn improves bone health.
Can ROKFOS INFUSION cause constipation?
Yes, ROKFOS INFUSION may cause constipation in some individuals. To manage this effect, try to eat more high-fiber foods such as fresh fruit, vegetables, and cereals, and drink plenty of water. If this does not help, inform your doctor about receiving alternate management for constipation.
Is ROKFOS INFUSION safe to use in pregnant or breast-feeding women?
ROKFOS INFUSION is not recommended for use in pregnant and breast-feeding women. Consult your doctor before receiving ROKFOS INFUSION if you are pregnant, planning to be pregnant, or breast-feeding.
Article Information
Written By
DETAILS Written By Srilekha. R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
23 Jul 2024