RIZ LS Tablet 10'S
Key Information
Generic Name
Generic Name Risperidone 2 mg+Trihexyphenidyl 2 mg
Manufacturer
Alkem Laboratories Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
RIZ LS TABLET is a combination of Risperidone and Trihexyphenidyl which belongs to a group of medicines called Atypical antipsychotics and Anticholinergics, respectively. It is used to manage schizophrenia, and acute manic episodes in affected individuals. Schizophrenia is a serious mental disorder that affects a person's ability to think, feel/behave clearly. Acute manic episode is a manic phase of bipolar I disorder which is defined as an extremely unstable or irritable mood along with excess activity or energy level in affected individuals. [GBKEYWORD] is not recommended for use in patients allergic to Risperidone, and/or Trihexyphenidyl. Before taking RIZ LS TABLET, inform your doctor if you have or ever had a stroke, involuntary movements of the tongue, mouth and face, Parkinson’s disease (brain disorder), dementia ( loss of cognitive functioning such as thinking, remembering, and reasoning), epilepsy, myasthenia gravis ( muscle weakness), tardive dyskinesia (neurological disorder), heart, kidney, and/or liver problems. RIZ LS TABLET is not recommended for use in pregnant women unless it is clearly necessary. It is also not recommended for use in breastfeeding women. The medicine is also not indicated for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65 years and above) after consulting the doctor. The most common
Uses
OF RIZ LS TABLET It is used to manage schizophrenia (serious mental disorder) and acute manic episodes (bipolar disorder)
How It Works
RIZ LS TABLET is used to manage schizophrenia and acute manic episodes, where Risperidone improves mood, thoughts and behavior by decreasing the levels of dopamine and serotonin (chemical messengers) in the brain, and Trihexyphenidyl improves muscle control and reduces stiffness in Parkinson's disease (brain disorder) by decreasing the level of acetylcholine (chemical messenger) in the brain, thus improving the symptoms.
Directions for Use
Take RIZ LS TABLET as advised by your physician. Swallow RIZ LS TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking RIZ LS TABLET are difficulty falling/staying asleep, common cold symptoms, sinus infection, diarrhea, indigestion, and/or dry mouth. Consult your doctor if any of these symptoms gets worse. USES OF RIZ LS TABLET It is used to manage schizophrenia (serious mental disorder) and acute manic episodes (bipolar disorder) HOW RIZ LS TABLET WORKSRIZ LS TABLET is used to manage schizophrenia and acute manic episodes, where Risperidone improves mood, thoughts and behavior by decreasing the levels of dopamine and serotonin (chemical messengers) in the brain, and Trihexyphenidyl improves muscle control and reduces stiffness in Parkinson's disease (brain disorder) by decreasing the level of acetylcholine (chemical messenger) in the brain, thus improving the symptoms. DIRECTIONS FOR USETake RIZ LS TABLET as advised by your physician. Swallow RIZ LS TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RIZ LS TABLETCOMMON Difficulty falling or staying asleep slow or impaired movement, sensation of stiffness or tightness of the muscles (making your movements jerky), and sometimes even a sensation of movement “freezing up” and then restarting, a slow shuffling walk, a tremor while at rest, increased saliva and/or drooling, and a loss of expression on the face Feeling sleepy, or less alert Headache Pneumonia (serious illness of lung) Infection of the chest (bronchitis) Common cold symptoms Sinus infection Signs of urinary tract infection such as strong urge to urinate, burning sensation while urination Ear infection such as ear pain, trouble sleeping, loss of balance Feeling like if having flu Signs of hyperprolactinemia (high prolactin levels) in men such as breast swelling, difficulty in getting or maintaining erections, decreased sexual desire or other sexual dysfunction. In women signs might include breast discomfort, leakage of milk from the breasts, missed menstrual periods, or other problems with your cycle or fertility problems Weight gain Increased appetite Decreased appetite Sleep disorder Irritability Depression Anxiety Restlessness Signs of dystonia (muscle disorder) such as abnormal movements of the eyes, mouth, tongue or jaw Dizziness Dyskinesia (a muscle disorder marked by uncontrolled, involuntary muscle movement) such as repetitive, spastic or writhing movements, or twitching Tremor (shaking) Signs of eye infections such as blurry vision, or pink eye Rapid heart rate High blood pressure Shortness of breath Sore throat Cough Nose bleeds Stuffy nose Abdominal pain or discomfort Vomiting Nausea Constipation Diarrhea Indigestion Dry mouth Toothache Rash, skin redness Muscle spasms Bone or muscle ache Back pain Joint pain Incontinence (lack of control) of urine Swelling of the body, arms or legs Chest pain Weakness Dryness of mouth Nervousness UNCOMMON Infection of the breathing passages Bladder infection Eye infection Tonsillitis (swollen tonsils) Fungal infection of the nails Single area of san infection confined to skin An infection confined to a part of the body Viral infection Skin inflammation caused by mites Anemia (decrease in red blood cells) Allergic reaction Diabetes or worsening of diabetes High blood sugar Excessive drinking of water Weight loss Loss of appetite resulting in malnutrition Low body weight Elated mood (mania) Confusion Decreased sexual drive Nervousness Nightmares Loss of consciousness Low level of consciousness Restless urge to move parts of your body Balance disorder Abnormal coordination Disturbance in attention Problems with speech Loss or abnormal sense of taste Low sensation of skin to touch and pain Tingling, pricking, or numbness sensation of skin Oversensitivity of the eyes to light Dry eye Increased tears Redness of the eyes Sensation of spinning (vertigo) Ringing in the ears Ear pain A fluttering or pounding feeling in your chest Low blood pressure Low blood pressure upon standing Flushing Pneumonia caused by inhaling food, lung congestion, congestion of breathing passages, crackle lung sounds, wheezing, voice disorder, breathing passage disorder Infection of stomach or intestine Stool incontinence, very hard stool Difficulty while swallowing Excessive passing of gas or wind Signs of allergic skin reactions such as red rash, itching skin Hair loss Signs of skin infections such as thickening of skin, dry skin, skin discolouration, acne, flaky, itchy scalp or skin, skin disorder, skin lesion Abnormal posture Joint stiffness Joint swelling Muscle weakness Neck pain Frequent passing of urine Inability to pass urine Pain when passing urine Erectile dysfunction Ejaculation disorder Signs of menstrual problems such as loss of menstrual periods, missed menstrual periods or other problems with your cycle (females) Development of breasts in men Leakage of milk from the breasts, breast pain, breast discomfort Discharge from vagina Sexual dysfunction Swelling of the face, eyes, lips, or mouth Chills Change in the way you walk Feeling thirsty Feeling unwell Chest discomfort Feeling out of sorts Discomfort RARE Infection Sleepwalking Sleep-related eating disorder Low blood sugar Lack of emotion Inability to reach orgasm Not moving or responding while awake (catatonia) Blood vessel problems in the brain such as stroke, aneurysms Coma due to uncontrolled diabetes Shaking of the head Problems related movement of eyes, eye rolling, eyelid margin crusting Eye problems during cataract surgery Intraoperative floppy iris syndrome (IFIS) (a complication that occurs during cataract surgery) Dangerously excessive intake of water Irregular heartbeat Trouble breathing during sleep (sleep apnoea) Fast or shallow breathing Pancreatitis (inflammation of the pancreas) A blockage in the bowels Swollen tongue Chapped lips Rash on skin related to drug Dandruff Delay in menstrual periods Enlargement of the breast glands, discharge from the breasts Hardening of the skin Low body temperature Coldness in arms and legs Symptoms of drug withdrawal such as anxiety, fatigue, sweating, vomiting, depression Signs of jaundice such as yellowing of the skin and the eyes Stop taking RIZ LS TABLET and contact your doctor if you experience any of the following side effects: Signs of stroke such as dementia, sudden change in your mental state or sudden weakness or numbness of your face, arms or legs, especially on one side, or slurred speech, even for a short period of time Signs of tardive dyskinesia (neurological disorder) such as twitching or jerking movements that you cannot control in your face, tongue, or other parts of your body) Involuntary rhythmic movements of the face, mouth, and tongue Convulsion (fits) Fainting Atrial fibrillation (an abnormal heart rhythm) Slow heart rate Signs of blood clots in the veins, especially in the legs such as swelling, pain, and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty breathing Signs of neuroleptic malignant syndrome (life threatening neurological disorder) such as fever muscle stiffness, sweating or a lowered level of consciousness Signs of priapism (sexual disorder) such as prolonged or painful erection in man Signs of severe allergic reaction such as fever, swollen mouth, face, eyelids, lip or tongue, shortness of breath, itching, skin rash Drop in blood pressure Glaucoma (increased pressure within the eyeball) Rhabdomyolysis (condition of breakdown of muscle fibers and pain in muscles) Dangerously low numbers of a certain type of white blood cell needed to fight infection in your blood Lightness in chest Difficult swallowing Restlessness Agitation Confusion Delusion (loss of sense of reality) Hallucinations Difficulty in sleeping False sense of well being Immediate or short-term memory loss Worsening of myasthenia gravis Large pupils Lack of near vision Eye discomfort Increased sensitivity to light Faster heartbeat Being sick Dry and redness of skin or skin rashes Inability to pass urine Difficulty while passing urine Thirst Fever
Warnings & Precautions
& PRECAUTIONSPREGNANCYConsult your doctorRIZ LS TABLET is not recommended for use in pregnant women unless it is clearly necessary. It should be used with caution in pregnant women during the third trimester period since the medicine might cause side effects such as shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding in newborn babies. Consult your doctor before taking RIZ LS TABLET. BREASTFEEDINGContraindicatedRIZ LS TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking RIZ LS TABLET. DRIVING AND USING MACHINESUse with CautionRIZ LS TABLET might cause dizziness, tiredness, mild nausea, and vision problems. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking RIZ LS TABLET. ALCOHOLConsult your doctorAvoid consumption of alcohol while taking RIZ LS TABLET. Consult your doctor before taking RIZ LS TABLET. KIDNEYUse with CautionRIZ LS TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking RIZ LS TABLET. LIVERUse with CautionRIZ LS TABLET should be used with caution in patients with liver problems. Consult your doctor before taking RIZ LS TABLET. ALLERGYContraindicatedRIZ LS TABLET is not recommended for use if you are allergic to Risperidone or Trihexyphenidyl, or any other ingredients of this medicine. HEART DISEASEConsult your doctorConsult your doctor before taking RIZ LS TABLET, if you have heart problems such as irregular heart rhythm. USE IN PEDIATRICSContraindicatedRIZ LS TABLET is not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking RIZ LS TABLET. USE IN GERIATRICSConsult your doctorRIZ LS TABLET should be used with caution in elderly patients (aged 65 years or above). It is not recommended for use in elderly patients suffering from dementia due to stroke. Medical management should be sought straight away if signs of stroke such as sudden change in mental state or sudden weakness or numbness of face, arms or legs, especially on one side, or slurred speech, even for a short period of time are noticed. Consult your doctor before taking RIZ LS TABLET. OTHERSBefore taking RIZ LS TABLET, inform your doctor if you: Have stroke due to high blood pressure, cardiovascular disease or blood vessel problems in brain Have experienced involuntary movements of the face, mouth, and tongue Have or ever had neuroleptic malignant syndrome (life threatening neurological disorder) with symptoms such as high temperature, muscle stiffness, sweating or a lowered level of consciousness Have Parkinson’s disease (brain disorder) Dementia ( loss of cognitive functioning such as thinking, remembering, and reasoning) Are diabetic Had an epilepsy You have or ever had a prolonged or painful erection Have problems controlling your body temperature or overheating Have hyperprolactinemia (high level of prolactin) Have a tumor dependent on prolactin hormone Or someone else in your family has a history of blood clots Have glaucoma High blood pressure Have prostate problems Have trouble passing urine Have stomach ulcer Have severe heartburn Have acid indigestion Have any other digestive disorders Have myasthenia gravis ( muscle weakness) Have tardive dyskinesia (neurological disorder)
Drug Interactions
SA. Drug-Drug Interactions: Before taking RIZ LS TABLET, inform your doctor, if you are taking any of the following medicine: Medicines that work on your brain such as to help you calm down Ex. benzodiazepines Medicines used for pain such as opiates (Ex. oxycodone, fentanyl, buprenorphine) Medicines used for allergy such as antihistamines (Ex. brompheniramine, cetirizine, chlorpheniramine) Medicines that may change the electrical activity of your heart, such as medicines used for malaria, heart rhythm problems (Ex. quinidine), allergies (antihistamines), some antidepressants (Ex. fluoxetine, citalopram, sertraline) or other medicines for mental problems Medicines that cause a slow heartbeat Ex. amiodarone, flecainide, propafenone Medicines that cause low blood potassium such as diuretics Ex. chlorthalidone, hydrochlorothiazide, metolazone Medicines used to manage elevated blood pressure Ex. amlodipine, felodipine, isradipine Medicines for Parkinson’s disease (brain disorder) Ex. levodopa Diuretics (medicines used for heart problems or swelling of parts of your body due to a build up of too much fluid) Ex. furosemide, chlorothiazide Medicines that increase the activity of the central nervous system such as psychostimulants Ex. methylphenidate Rifampicin (medicine used for managing some infections) Carbamazepine, phenytoin (medicines used for epilepsy) Phenobarbital (medicine used to control seizures) Quinidine (medicine used for certain types of heart disease) Antidepressants (medicines used for depression) Ex. paroxetine, fluoxetine, tricyclic antidepressants Medicines used to manage high blood pressure such as beta blockers Ex. atenolol, bisoprolol, carvedilol Phenothiazines (medicines used to manage psychosis or to calm down) Ex. chlorpromazine, thioridazine, fluphenazine, mesoridazine, perphenazine Cimetidine, ranitidine (medicines used for stomach acidity) Itraconazole, ketoconazole (medicines used for managing fungal infections) Certain medicines used in the management of HIV/AIDS Ex. ritonavir Verapamil (medicine used to manage high blood pressure and/or abnormal heart rhythm) Sertraline, fluvoxamine (medicines used to manage depression and other psychiatric disorders) Aspirin (medicine used for fever and to relieve mild to moderate pain from headaches, toothaches) Monoamine oxidase inhibitors (medicines used for depression) Ex. moclobemide, tranylcypromine Disopyramide (medicine used for irregular heartbeat) Amantadine (medicine used for viral infections) Nefopam (medicine used as a painkiller) Metoclopramide or domperidone (medicine used to manage nausea and vomiting) Parasympathomimetics (medicines used in the management of urinary retention) Ex. neostigmine, bethanechol Overdosage: If you or anyone else accidentally takes too much of RIZ LS TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sleepy or tired, or having abnormal body movements, problems standing and walking, feeling dizzy due to low blood pressure, or having abnormal heartbeats or fits. SYNOPSIS Drug : Risperidone, Trihexyphenidyl Pharmacological Category : Atypical antipsychotics, Anticholinergics Therapeutic Indication : Schizophrenia, Acute manic episodes Dosage Forms : Tablet MORE INFORMATIONSTORAGE Keep the medicine out of reach in children Store RIZ LS TABLET at room temperature
Frequently Asked Questions
Common questions and answers about RIZ LS Tablet 10'S.
What RIZ LS TABLET is used for?
RIZ LS TABLET is used to manage schizophrenia, and acute manic episodes. Schizophrenia is a serious mental disorder that affects a person's ability to think, feel and behave clearly which results in impairred daily functioning in a person. Acute manic episode is a manic phase of bipolar I disorder which is defined as an extremely unstable or irritable mood characterized by excessive rapid thought and speech, reckless behavior and feeling of invincibility.
Can RIZ LS TABLET be used in elderly patients?
Yes, RIZ LS TABLET can be used but with caution in elderly patients (aged 65 years and above). It is not recommended for use in elderly patients suffering from dementia due to stroke. Medical management should be sought straight away if signs of stroke such as sudden change in mental state or sudden weakness or numbness of face, arms or legs, especially on one side, or slurred speech, even for a short period of time are noticed. Consult your doctor before taking RIZ LS TABLET.
What side effects are seen with RIZ LS TABLET?
The most common side effects of taking RIZ LS TABLET are difficulty falling/staying asleep, common cold symptoms, sinus infection, diarrhea, indigestion, and/or dry mouth. Consult your doctor if any of these symptoms worsens.
Is it safe to drive after taking RIZ LS TABLET?
RIZ LS TABLET might cause dizziness, tiredness, mild nausea, and vision problems. If you experience any such side effects, then try to avoid driving or operating heavy machines.
What happens if you take more RIZ LS TABLET than your required dose?
If you or anyone else accidentally takes too much of RIZ LS TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sleepy or tired, or having abnormal body movements, problems standing and walking, feeling dizzy due to low blood pressure, or having abnormal heartbeats or fits.
Article Information
Written By
DETAILS Written By Dr. Janet.C
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
10 Jul 2024