RIBOREA Capsule 10's
Key Information
Generic Name
Generic Name Hydroxyurea 500 mg
Manufacturer
Khandelwal Laboratories Pvt Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT RIBOREA CAPSULERIBOREA CAPSULE contains Hydroxyurea, which belongs to a group of medicines called Antimetabolites. It is used to manage resistant chronic myeloid leukaemia and locally advanced squamous cell cancer of the head and neck (excluding the lip) and cervical cancer. RIBOREA CAPSULE is not recommended for use in patients with a history of any blood problems or severe anaemia. RIBOREA CAPSULE should be used with caution in patients with liver, lung or kidney disease and myelosuppression (leukopenia, thrombocytopenia, anaemia). RIBOREA CAPSULE is not recommended for use during pregnancy. RIBOREA CAPSULE is not recommended for use by breastfeeding women. RIBOREA CAPSULE is also not recommended for use in children as its safety and effectiveness are not established. RIBOREA CAPSULE should be used with caution in the elderly aged 65 years or above. The most common
Uses
OF RIBOREA CAPSULE Manage resistant chronic myeloid leukaemia Manage locally advanced squamous cell carcinomas of the head and neck, (excluding lip) Manage cervical cancer
How It Works
RIBOREA CAPSULE gets converted to free radical nitroxide (NO), which enters the cells, inactivates the ribonucleotide reductase enzyme and causes immediate inhibition of DNA synthesis, leading to cell death.
Directions for Use
Take RIBOREA CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking RIBOREA CAPSULE are loss of appetite, weakness, loss of energy, sickness, diarrhoea, constipation, abdominal pain, hair loss, blood disorders (decrease in white blood cells, red blood cells and platelets), low back pain, black tarry stools or blood in the stools, unusual bleeding or bruising, muscle weakness, sores on the lips or mouth etc. Contact your physician if any of the symptoms worsen. USES OF RIBOREA CAPSULE Manage resistant chronic myeloid leukaemia Manage locally advanced squamous cell carcinomas of the head and neck, (excluding lip) Manage cervical cancer HOW RIBOREA CAPSULE WORKSRIBOREA CAPSULE gets converted to free radical nitroxide (NO), which enters the cells, inactivates the ribonucleotide reductase enzyme and causes immediate inhibition of DNA synthesis, leading to cell death. DIRECTIONS FOR USETake RIBOREA CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RIBOREA CAPSULECOMMON blood disorders (decrease in white blood cells, red blood cells and platelets) low back pain black tarry or blood in stools unusual bleeding or bruising skin changes (dermatomyositis) a scaly, purple, raised rash on the face, hands or other parts of the body with redness, darkening of the skin, peeling of the skin and worsening of redness or skin and mucous membrane discomfort in patients with a history of radiation muscle weakness - symptoms such as muscle tenderness, muscle weakness or tiredness when climbing stairs, walking or rising from a chair etc sores on the lips or mouth difficulty or pain passing urine azoospermia or oligospermia (absence or decreased amount of sperm in the semen) anorexia, weakness, decreased energy sickness, diarrhoea, constipation, abdominal pain hair loss kidney problems unexplained shortness of breath or cough with fever numbness or tingling of hands or feet skin cancer problems with the flow of the bile (cholestasis) causing itchiness, yellowish discolouration of skin or whites of eye, very dark urine, pale stools inflammation of the liver (hepatitis), which causes flu-like symptoms, including tiredness, loss of appetite, fever, pain, nausea, vomiting, pressure or pain below the right ribs and might also include yellowing of the skin or eyes drowsiness, dizziness, fits, confusion or hallucinations headache RARE skin ulceration with severe infection tumour lysis syndrome Stop taking RIBOREA CAPSULE and contact your physician immediately if you experience any of the following side effects: allergic reaction such as skin rashes, itching, swelling of the face, lips, tongue or throat causing difficulty breathing unexplained fever, chills, sore throat or cough wasting of muscles peeling of the skin and nails high fever with stomach, lung, muscle, liver, skin or heart problems within 6 weeks of taking RIBOREA CAPSULE
Warnings & Precautions
& PRECAUTIONSPREGNANCYRIBOREA CAPSULE is not recommended for use by pregnant women. Inform your doctor if you expect or are planning for pregnancy. Avoid becoming pregnant while taking RIBOREA CAPSULE. Contact your doctor before taking RIBOREA CAPSULE. BREASTFEEDINGRIBOREA CAPSULE is not recommended for use by breastfeeding women as it may pass through breast milk to the breastfed baby. Contact your doctor before taking RIBOREA CAPSULE. DRIVING AND USING MACHINESDo not drive or operate any machines if you feel drowsy after taking RIBOREA CAPSULE. ALCOHOLAvoid consuming alcohol while taking this medicine, as it may lead to unwanted effects. KIDNEYRIBOREA CAPSULE should be used with caution in patients with kidney disease. Contact your doctor before taking RIBOREA CAPSULE. LIVERRIBOREA CAPSULE should be used with caution in patients with liver disease. Contact your doctor before taking RIBOREA CAPSULE. ALLERGYDo not take RIBOREA CAPSULE if you are allergic to Hydroxyurea or lactose or some sugars or other ingredients in this medicine. LUNGSRIBOREA CAPSULE should be used with caution in patients with pulmonary fibrosis, lung infiltration, pneumonitis and alveolitis or allergic alveolitis. Contact your doctor before taking RIBOREA CAPSULE. OTHERSRIBOREA CAPSULE is not recommended for use if you have: history of blood disorders severe anaemia Before taking RIBOREA CAPSULE, inform your doctor if you have: myelosuppression (leukopenia, thrombocytopenia, anaemia) previously received radiotherapy or chemotherapy myeloproliferative disorders secondary leukaemia skin cancer cutaneous vasculitis ulcers and gangrene gout leg ulcers folic acid deficiency HIV infection pancreatitis, hepatotoxicity and peripheral neuropathy live vaccines radiation macrocytosis (enlarged red blood cells) sickle cell anaemia blood test for uric acid, urea or lactic acid Use in paediatrics: RIBOREA CAPSULE is not recommended for use in children as safety and effectiveness are not established. Contact your doctor before taking RIBOREA CAPSULE. Use in geriatrics: RIBOREA CAPSULE should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking RIBOREA CAPSULE.
Drug Interactions
SA. Drug-Drug interactions: Before taking RIBOREA CAPSULE, inform your doctor if you are taking any of the following medicine: antiretroviral medicines (medicines used to manage viral infections such as HIV) Ex. didanosine, stavudine and indinavir medicines which suppress the bone marrow (Ex. chemotherapies and radiation therapy) vaccines (medicines used to manage infections) Overdosage: If you or anyone else accidentally take too much of RIBOREA CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are acute mucocutaneous toxicity, soreness, violet erythema, swelling of hands and feet, followed by scaling of hands and feet, severe generalized hyperpigmentation of the skin and stomatitis. SYNOPSIS Drug : Hydroxyurea Pharmacological Category : Antimetabolites Therapeutic Indication : resistant chronic myeloid leukaemia, locally advanced squamous cell cancer of the head and neck (excluding lip), cervical cancer Dosage Forms : Capsule MORE INFORMATION Keep RIBOREA CAPSULE out of the sight and reach from children Store RIBOREA CAPSULE below 25°C
Article Information
Written By
DETAILS Written By Dr. Dhivakaran R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
27 Sep 2022