PRIFEDON 400 Tablet 15's

Idiopathic Pulmonary Fibrosis (31)Rx required

Key Information

Generic Name

Generic Name Pirfenidone 400 mg

Manufacturer

PREVEGO HEALTHCARE & RESEARCH PRIVATE LIMITED (Generics)

Variant

15 Tablet(s) in a Strip

Country of Origin

India

Detailed Information

Introduction

INTRODUCTIONPRIFEDON 400 contains Pirfenidone which belongs to the group of medicines called Anti-fibrotics or Anti-inflammatory agents. It is used in the management of mild to moderate Idiopathic pulmonary fibrosis in adults. Idiopathic pulmonary fibrosis is a condition in which the tissues in the lungs (alveoli) become swollen and scarred over time and making it difficult to breathe. This makes it hard for the lungs to work properly. PRIFEDON 400 is not recommended for use in patients with severe or end-stage liver or kidney disease. Before taking PRIFEDON 400 inform your doctor if you have mild to moderate liver disease, kidney problems or photosensitivity reactions. PRIFEDON 400 is not recommended for use in pregnant women unless advised by your doctor. It is not known whether PRIFEDON 400 passes into breast milk, hence consult your doctor before taking this medicine. PRIFEDON 400 is not recommended for use in children and adolescents below 18 years of age. PRIFEDON 400 should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking this medicine. Avoid smoking while using PRIFEDON 400 as it reduces the effect of this medicine. Also, avoid drinking grapefruit juice as it may lead to unwanted effects. The most common

Uses

OF PRIFEDON 400 Manages idiopathic pulmonary fibrosis

How It Works

PRIFEDON 400 works by exhibiting anti-inflammatory, antioxidant and antifibrotic properties that suppress the factors (transforming growth factor -β (TGF-β)) causing scarring and swelling of the tissues. As a result, it manages and controls the fibrosis of the tissues resulting in improving lung function.

Directions for Use

Take PRIFEDON 400 as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects

taking PRIFEDON 400 are nausea, stomach problems such as acid reflux, vomiting, constipation, diarrhoea, indigestion or stomach upset, weight loss, decreased appetite, tiredness, dizziness, headache. Consult your doctor if any of the above side effects worsen. USES OF PRIFEDON 400 Manages idiopathic pulmonary fibrosis HOW PRIFEDON 400 WORKSPRIFEDON 400 works by exhibiting anti-inflammatory, antioxidant and antifibrotic properties that suppress the factors (transforming growth factor -β (TGF-β)) causing scarring and swelling of the tissues. As a result, it manages and controls the fibrosis of the tissues resulting in improving lung function. DIRECTIONS FOR USETake PRIFEDON 400 as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF PRIFEDON 400COMMON infections of the throat or the airways and sinusitis, influenza and/or common cold nausea stomach problems such as acid reflux, vomiting, constipation, diarrhoea, indigestion or stomach upset weight loss decreased appetite difficulty sleeping tiredness, dizziness, headache shortness of breath joint pain bladder infections feeling sleepy change in taste sensation hot flushes bloating, abdominal pain and discomfort, heartburn, and flatulence elevated liver enzymes sunburn or skin reactions due to exposure in the sun or to sun lamps skin problems such as rashes, itchy skin, redness, dry skin muscle pain weakness or feeling low in energy chest pain UNCOMMON headache, dizziness, confusion, weakness, muscle cramps or nausea and vomiting (due to low levels of sodium in the blood) Stop taking PRIFEDON 400 and contact your doctor immediately if you experience any of the following side effects: signs of angioedema or serious allergic reactions or anaphylaxis such as urticaria, itching, swelling of the face, lips, tongue or throat causing difficulty in breathing or feeling faint signs of abnormal liver function such as yellowish discolouration of skin and white of the eye, dark urine, itching of the skin, pain on the upper right side of the abdomen, loss of appetite, bleeding or bruising more easily and tiredness signs and symptoms of stevens-johnson syndrome or toxic epidermal necrolysis such as fever and flu-like symptoms followed by reddish or circular patches on the trunk, often with central blisters, peeling of the skin, ulcers on mouth, throat, eyes, nose and genitals

Warnings & Precautions

& PRECAUTIONSPREGNANCYPRIFEDON 400 is not recommended for use if you are pregnant, planning to become pregnant or think you might be pregnant as the potential risks to the unborn child are unknown. Consult your doctor before taking PRIFEDON 400. BREASTFEEDINGIt is not known whether PRIFEDON 400 pass through the breast milk, hence, consult your doctor before taking PRIFEDON 400. DRIVING AND USING MACHINESDo not drive or operate any machines if you feel dizzy or tired after taking PRIFEDON 400. KIDNEYPRIFEDON 400 is not recommended for use in patients with severe or end-stage kidney disease (requiring dialysis). It should be used with caution in patients with mild to moderate kidney problems. Consult your doctor before taking PRIFEDON 400. LIVERPRIFEDON 400 is not recommended for use in patients with severe or end-stage liver disease. It should be used with caution in patients with mild to moderate liver disease. Consult your doctor before taking PRIFEDON 400. ALLERGYDo not take PRIFEDON 400 if you are allergic to Pirfenidone. OTHERSBefore taking PRIFEDON 400, inform your doctor if you: have photosensitive reactions (more sensitive) to sunlight are a smoker Use in pediatrics: PRIFEDON 400 is not recommended for use in children and adolescents under 18 years of age. Contact child’s doctor for advice. Use in geriatrics: PRIFEDON 400 should be taken with caution in elderly patients (above 65 years of age) Your doctor will decide the dose, duration of the management and its frequency for you depending on the severity of your existing condition and other comorbid diseases.

Drug Interactions

SA. Drug-Drug Interaction: Before taking PRIFEDON 400, inform your doctor if you are taking any of the following medicines: fluvoxamine (used to manage depression and obsessive-compulsive disorder) chloramphenicol, enoxacin, ciprofloxacin, doxycycline (used to manage bacterial infections) amiodarone, propafenone, mexiletine, quinidine (used to manage heart rhythm disorders) omeprazole, esomeprazole (used to manage indigestion or acid reflux) rifampicin, rifampin (used to manage tuberculosis). methoxsalen (used to manage skin diseases like psoriasis and vitiligo) oral contraceptives such as ethinyl estradiol or norethindrone (used to prevent pregnancy) miconazole, fluconazole, voriconazole, terbinafine (used to manage fungal infections) moclobemide, fluoxetine, duloxetine, paroxetine (used to manage depression) bupropion (helps to stop smoking) cinacalcet (used to manage hyperparathyroidism) phenytoin, carbamazepine (used to manage fits) B. Drug - Food interaction: Avoid drinking grapefruit juice while taking PRIFEDON 400 as it may lead to unwanted effects. Consult your doctor before taking PRIFEDON 400. Overdosage: If you or anyone else accidentally take too much of PRIFEDON 400, consult your doctor immediately or visit the nearby hospital. SYNOPSIS Drug : Pirfenidone Pharmacological Category : Anti-fibrotics or Anti-inflammatory agents Therapeutic Indication : Mild to moderate Idiopathic Pulmonary Fibrosis Dosage Forms : Tablet MORE INFORMATION Keep PRIFEDON 400 out of reach of children Store at room temperature

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