PREGATRON TRIO Tablet 10's
Key Information
Generic Name
Generic Name Methylcobalamin 1500 mcg+Nortriptyline 10 mg+Pregabalin 75 mg
Manufacturer
PREVEGO HEALTHCARE & RESEARCH PRIVATE LIMITED (Generics)
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
PREGATRON TRIO TABLET is a combination of Methylcobalamin, Nortriptyline and Pregabalin which belongs to the group of medicines called Vitamins, Antidepressants and Anticonvulsants respectively. It is used to manage diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency. Neuropathic pain is a form of pain where there is a damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body. Patients taking PREGATRON TRIO TABLET may have thoughts of harming or killing themselves. If at any time you have these thoughts, immediately consult your physician. Avoid consumption of alcohol during management with PREGATRON TRIO TABLET as it may cause dizziness. Before taking PREGATRON TRIO TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. PREGATRON TRIO TABLET is not recommended for use in pregnant women unless advised by the doctor and not recommended for breast-feeding women. Elderly patients above 65 years of age always should consult the physician before taking it. The most common
Uses
OF PREGATRON TRIO TABLET Manage diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency
How It Works
PREGATRON TRIO TABLET is a combination of methylcobalamin, nortriptyline and pregabalin, where methylcobalamin is a form of vitamin B that helps in the production of myelin (a substance that protects nerve fibers) and regenerates damaged nerve cells. Nortriptyline is a tricyclic antidepressant that increases the chemical messenger levels (serotonin and noradrenaline) that stops the movement of pain signals in the brain. Pregabalin is an anticonvulsant (alpha 2 delta ligand) that decreases pain by altering the calcium channel activity of the nerve cells. Together, methylcobalamin, nortriptyline and pregabalin helps to relieve neuropathic pain (pain from damaged nerves).
Directions for Use
Always take PREGATRON TRIO TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PREGATRON TRIO TABLET for you depending upon your age, body weight and disease condition. Do not stop taking PREGATRON TRIO TABLET without informing your doctor.
Side Effects
PREGATRON TRIO TABLET Manage diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency HOW PREGATRON TRIO TABLET WORKSPREGATRON TRIO TABLET is a combination of methylcobalamin, nortriptyline and pregabalin, where methylcobalamin is a form of vitamin B that helps in the production of myelin (a substance that protects nerve fibers) and regenerates damaged nerve cells. Nortriptyline is a tricyclic antidepressant that increases the chemical messenger levels (serotonin and noradrenaline) that stops the movement of pain signals in the brain. Pregabalin is an anticonvulsant (alpha 2 delta ligand) that decreases pain by altering the calcium channel activity of the nerve cells. Together, methylcobalamin, nortriptyline and pregabalin helps to relieve neuropathic pain (pain from damaged nerves). DIRECTIONS FOR USEAlways take PREGATRON TRIO TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PREGATRON TRIO TABLET for you depending upon your age, body weight and disease condition. Do not stop taking PREGATRON TRIO TABLET without informing your doctor. SIDE EFFECTS OF PREGATRON TRIO TABLETCOMMON dizziness, sleepiness trouble concentrating, blurry vision dry mouth weight gain swelling of your hands or feet RAREStop taking PREGATRON TRIO TABLET and contact your physician immediately if you experience any of the following side effects: hypersensitivity or allergic reactions (symptoms include skin redness, blisters, hives, rash, dyspnoea and wheezing) have feelings of harming or killing themselves
Warnings & Precautions
& PRECAUTIONSPREGNANCYMonitoring requiredPREGATRON TRIO TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it. BREASTFEEDINGContraindicatedPREGATRON TRIO TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your physician before taking it. DRIVING AND USING MACHINESUse with CautionDo not drive or operate heavy machines if you experience dizziness while taking PREGATRON TRIO TABLET. Consult with your physician for advice before taking the medicine. ALCOHOLContraindicatedConsumption of alcohol is not recommended during management with PREGATRON TRIO TABLET as it may cause dizziness. KIDNEYUse with CautionPREGATRON TRIO TABLET should be used with caution in patients with kidney problems. Consult with your doctor for advice before taking PREGATRON TRIO TABLET. LIVERUse with CautionPREGATRON TRIO TABLET should be used with caution in patients with liver problems. Consult with your doctor for advice before taking PREGATRON TRIO TABLET. ALLERGYContraindicatedDo not take PREGATRON TRIO TABLET if you are allergic to Methylcobalamin, Nortriptyline, Pregabalin or any other ingredients of this medicine. USE IN GERIATRICSUse with CautionPREGATRON TRIO TABLET should be used with caution in elderly patients above 65 years of age. Consult with your physician for advice before taking PREGATRON TRIO TABLET. OTHERSBefore taking PREGATRON TRIO TABLET, inform your physician if you have: angioedema diabetes major depressive disorder
Drug Interactions
SA. Drug-Drug interactions: Before taking PREGATRON TRIO TABLET inform your physician if you are taking any of the following medicines: medicines used as opioid analgesics such as oxycodone, tramadol (used to manage severe pain) medicine used to manage depression and anxiety (Ex. lorazepam, diazepam, MAO inhibitors like isocarboxazid) medicines used to manage gastroesophageal reflux (Ex. cimetidine, ranitidine) oral contraceptives such as desogestrel and ethinyl estradiol (used to manage pregnancy) medicines used for cancer chemotherapy (Ex. arsenic trioxide) medicines used to manage bacterial infections (Ex. chloramphenicol, azithromycin, clarithromycin and linezolid) reserpine (used to manage high blood pressure) anticholinergic drugs such as dicyclomine (used to manage the symptoms of irritable bowel syndrome) sympathomimetic drugs such as norepinephrine (used to raise blood pressure in emergency condition) Overdosage: If you or anyone else accidentally takes too much of PREGATRON TRIO TABLET, consult your physician immediately or visit the nearby hospital. SYNOPSIS Drug : Methylcobalamin, Nortriptyline, Pregabalin Pharmacological Category : Vitamin, Tricyclic antidepressant and Anticonvulsant Therapeutic Indication : Neuropathic Pain Dosage Forms : Capsule, Tablet MORE INFORMATION Keep PREGATRON TRIO TABLET out of reach to children Store at room temperature
Frequently Asked Questions
Common questions and answers about PREGATRON TRIO Tablet 10's.
When to seek medical emergency while taking PREGATRON TRIO TABLET?
Stop taking PREGATRON TRIO TABLET and contact your physician immediately if you experience angioedema (symptoms include swelling of the face, mouth (tongue, lips and gums) and neck (throat and larynx)) and have thoughts of harming or killing themselves.
What to do If I forget to take a dose of PREGATRON TRIO TABLET?
You should take PREGATRON TRIO TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Does PREGATRON TRIO TABLET impair my ability to drive?
Yes, PREGATRON TRIO TABLET may cause dizziness, do not drive or operate any machines which require concentration because it can impair your ability to work. Follow appropriate precautions before driving or you may ask someone to drive for you after consulting with your physician.
What is the precaution to be followed before taking PREGATRON TRIO TABLET?
PREGATRON TRIO TABLET is not recommended to use among women who are breast-feeding and pregnant unless advised by the doctor. Before taking PREGATRON TRIO TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. It should be used with caution in elderly patients.
Can PREGATRON TRIO TABLET be used in patients with liver or kidney problems?
PREGATRON TRIO TABLET should be used with caution in patients with kidney or liver problems. Your doctor may monitor your liver and kidney function test to manage the risk of any unusual effects. Consult your doctor before taking it.
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
06 Mar 2023