PREGARICH NT Tablet 10's

Neuropathic Pain (649)Rx required

Key Information

Generic Name

Generic Name Nortriptyline 10 mg+Pregabalin 75 mg

Manufacturer

Ikon Remedies Pvt Ltd

Variant

10 Tablet(s) in a Strip

Country of Origin

India

Detailed Information

Introduction

PREGARICH NT TABLET is a combination of Nortriptyline and Pregabalin which belongs to the group of medicines called Tricyclic antidepressants and Anticonvulsants respectively. PREGARICH NT TABLET is indicated for the management of neuropathic pain. Neuropathic pain is a chronic painful nerve condition caused by damage or disease affecting the somatosensory (sense of touch) nervous system. It can be caused by injury or disease of spinal cord and/or brain, prolonged diabetes mellitus (Ex. diabetic neuropathy), infectious diseases (such as HIV infection or leprosy), chemotherapy, auto-immune disease (Ex. Guillain-Barre syndrome), post-herpetic neuralgia (a long-lasting painful condition that affects the areas around the skin and nerve fibers where shingles were present), fibromyalgia (generalized musculoskeletal pain with fatigue and altered sleep, memory, and mood) or by other metabolic dysfunctions. Symptoms include shooting, burning or stabbing pain for normal daily activities that are typically not painful, tingling and numbness or spontaneous pain (pain without stimulus). Continue to take PREGARICH NT TABLET as long as your doctor tells you to do so because premature discontinuation can cause withdrawal symptoms like insomnia, headache, nausea, anxiety, diarrhea, depression, convulsion and excessive perspiration. PREGARICH NT TABLET can increase the risk of suicidal thoughts and behavior in some individuals and therefore patients (or caregivers) should seek immediate medical advice if any such signs emerge. PREGARICH NT TABLET is not recommended for use in patients having severe heart or kidney disease. Consult your doctor before taking PREGARICH NT TABLET. This medicine is not recommended for use in pregnant women unless advised by the doctor and it is not recommended for use in breastfeeding women. PREGARICH NT TABLET is strictly not recommended for use in children aged below 6 years and it should be taken with caution in elderly patients (aged 65 years or above). The most common

Uses

OF PREGARICH NT TABLET Manage neuropathic pain

How It Works

PREGARICH NT TABLET effectively relieves nerve pain, where nortriptyline acts by inhibiting the movement of pain signals from the brain by blocking the reuptake of certain chemical messengers (norepinephrine and serotonin) at the pre-synapse and pregabalin acts by interfering with influx of calcium and various pain signals travelling through the damaged nerves and the brain, thus leading to a significant pain relief in various neuropathic pain states.

Directions for Use

Always take PREGARICH NT TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PREGARICH NT TABLET for you depending upon your age, body weight and disease condition. Do not stop taking PREGARICH NT TABLET without informing your doctor.

Side Effects

taking PREGARICH NT TABLET are nausea, vomiting, constipation, dizziness, headache, flatulence and dry mouth. Consult your doctor if any of the side effects worsen. USES OF PREGARICH NT TABLET Manage neuropathic pain HOW PREGARICH NT TABLET WORKSPREGARICH NT TABLET effectively relieves nerve pain, where nortriptyline acts by inhibiting the movement of pain signals from the brain by blocking the reuptake of certain chemical messengers (norepinephrine and serotonin) at the pre-synapse and pregabalin acts by interfering with influx of calcium and various pain signals travelling through the damaged nerves and the brain, thus leading to a significant pain relief in various neuropathic pain states. DIRECTIONS FOR USEAlways take PREGARICH NT TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PREGARICH NT TABLET for you depending upon your age, body weight and disease condition. Do not stop taking PREGARICH NT TABLET without informing your doctor. SIDE EFFECTS OF PREGARICH NT TABLETCOMMON dizziness, drowsiness, headache nausea or vomiting dry mouth diarrhea, constipation, swollen abdomen, flatulence increased appetite, weight gain blurred vision vertigo (spinning sensation) mania, confusion, irritability, disorientation insomnia (lack of sleep) or sleepiness decreased sex drive, erectile dysfunction lack of control over body movements, tremor (shaking) memory impairment, attention disturbance dysarthria (unable to speak properly) numbness or pain in the body generalized edema (swelling of the body including extremities) muscle cramps pain in the joints, back or limbs sore throat UNCOMMON loss of appetite and weight loss decreased blood glucose level low self-esteem, depression, agitation, hallucinations, nightmares, panic attack, apathy mental impairment or difficulty with thinking increase in sexual interest eye problems (problems in vision, dry eyes, eye irritation, swelling or pain) skin sensitivity, loss of taste weakness or fainting increased sensitivity to noise heart problems (such as changes in heart rate, changes in blood pressure or heart failure) hot flushes difficulty in breathing, dry nose, nasal congestion increased saliva secretion, heartburn, numbness around the mouth skin rash, sweating, chills with fever muscle stiffness or twitching, joint swelling, neck pain pain in breasts difficulty or painful urination, increased urge to urinate excessive thirst, chest tightness severe allergic reactions (such as swollen face, itching, nasal congestion, nasal bleeds, cough, and snoring) painful menstrual periods chillness of hands and feet RARE ascites (fluid buildup in abdomen) fluid buildup in the lungs discharge from the breast or abnormal breast growth gynecomastia (breast enlargement in males) cold sweat, swollen throat, tightness of throat difficulty in swallowing abnormal smell sense altered vision, vision loss, dilated pupils, cross eyes inflammation of the pancreas slow or reduced movement of the body difficulty in writing convulsions irregular menstrual cycle rhabdomyolysis (muscle damage) kidney failure, decreased urine output, difficulty in urination allergic reactions (such as difficulty in breathing, inflammation of the eyes and a serious skin reaction characterized by rash, blisters, pain, and skin peeling) liver problems (such as jaundice (yellowing of the skin and eyes), liver failure or hepatitis (inflammation of the liver)) Stop taking PREGARICH NT TABLET and consult your doctor immediately if you experience the following side effects: swollen face or tongue skin redness with blisters or peeling

Warnings & Precautions

& PRECAUTIONSPREGNANCYPREGARICH NT TABLET is not recommended for use in pregnant women or women of childbearing age unless considered clearly necessary. Consult your doctor before taking PREGARICH NT TABLET. BREASTFEEDINGPREGARICH NT TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking PREGARICH NT TABLET. DRIVING AND USING MACHINESDo not drive or operate any tools or machines if you experience impairment of mental and physical, dizziness or sleepiness after taking PREGARICH NT TABLET. ALCOHOLAvoid consumption of alcohol while taking PREGARICH NT TABLET as it could make you feel dizzier or sleepier. KIDNEYPREGARICH NT TABLET should be taken with caution in patients with kidney disease. Consult your doctor before taking PREGARICH NT TABLET. LIVERPREGARICH NT TABLET is not recommended for use in patients having severe liver disease and should be used with caution in patients with liver disease. Consult your doctor before taking PREGARICH NT TABLET. ALLERGYDo not take PREGARICH NT TABLET if you are allergic to Pregabalin, Nortriptyline or any other tricyclic antidepressants such as amitriptyline, imipramine. HEART DISEASEPREGARICH NT TABLET is not recommended for use in patients having heart disease (such as recent heart attack, heart block or cardiac arrhythmias). Consult your doctor before taking PREGARICH NT TABLET. OTHERSPREGARICH NT TABLET is not recommended for use if you: have mania (abnormally excited mood) Before taking PREGARICH NT TABLET, inform your physician if you: have anxiety, hyperactivity or schizophrenia (disorder of thinking) have or had a history of alcoholism or substance abuse have suicidal ideation or aggressive behavior have or had a history of epilepsy have thyroid disorder are going to have an electroconvulsive therapy have diabetes have an enlarged prostate are going to receive an anesthetic have narrow angle glaucoma (an eye condition) Use in pediatrics: PREGARICH NT TABLET is strictly not recommended for use in children aged below 6 years. Consult your child’s doctor for advice. Use in geriatrics: PREGARICH NT TABLET should be taken with caution in elderly patients (aged 65 years or above). Proper dose titration (preferably lower doses) and careful monitoring are required to rule out any unwanted side effects. Consult your doctor for advice before taking PREGARICH NT TABLET.

Drug Interactions

SA. Drug-Drug interactions: Before taking PREGARICH NT TABLET inform to your doctor, if you are taking any of these medicines: other antidepressants (used to manage depression) Ex. fluoxetine, sertraline, amitriptyline, imipramine antipsychotics (used to manage mental illness) Ex. chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine sympathomimetic agents (used to manage respiratory or circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine medicines used to manage high blood pressure (Ex. guanethidine, betanidine, debrisoquine, clonidine, reserpine) medicines used to manage irregular heartbeat (Ex. quinidine, propafenone, flecainide and encainide) valproic acid, carbamazepine (used to manage epilepsy) medicines used to reduce anxiety such as barbiturates (Ex. phenobarbital, pentobarbital) or lorazepam cimetidine (used to manage stomach ulcers) oxycodone (used to manage pain) Overdosage: If you or anyone else accidentally take too much of PREGARICH NT TABLET, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PREGARICH NT TABLET include somnolence, restlessness, confusion, dizziness, change in body temperature, vomiting, blurred vision, abnormal heart rate, seizures, dry mouth or breathing difficulties. SYNOPSIS Drug : Nortriptyline, Pregabalin Pharmacological Category : Tricyclic antidepressants, Anticonvulsants Therapeutic Indication : Neuropathic pain Dosage Forms : Tablet MORE INFORMATION Keep PREGARICH NT TABLET out of reach of children Store PREGARICH NT TABLET at room temperature

Article Information

DW

Written By

DETAILS Written By Dr. R. Dinesh John Rajkumar

Medical Content Writer

DS

Reviewed By

Dr. Sankara Babu Gorle

Medical Expert

Last Updated

25 Nov 2022

Tags

#neuropathic pain (649)#generic name nortriptyline 10 mg+pregabalin 75 mg