Plagerine A 75mg Capsule 10'S
Key Information
Generic Name
Generic Name Aspirin 75 mg+Clopidogrel 75 mg
Manufacturer
Micro Labs Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT PLAGERINE A 75MG CAPSULEPLAGERINE A 75MG CAPSULE is a combination of Aspirin and Clopidogrel which belongs to the group of medicines called Antiplatelets. PLAGERINE A 75MG CAPSULE is used in the management of early and long-term atherothrombotic events such as myocardial infarction (also known as heart attack), stroke (reduced blood supply to brain leading to brain death), cardiovascular death or refractory ischemia (chest pain due to inadequate blood supply to the heart) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion). Acute coronary syndrome is a heart condition caused by plaque rupture or clot formation in the coronary arteries. Symptoms include heart attack, chest pressure or pain while at rest, shortness of breath and sweating. Along management with PLAGERINE A 75MG CAPSULE follow a healthy low-fat diet as advised by doctor to achieve better results. Avoid drinking alcohol during management with PLAGERINE A 75MG CAPSULE, as it could increase the risk of bleeding in the gastrointestinal tract. Do not stop taking PLAGERINE A 75MG CAPSULE abruptly without consulting your doctor because premature discontinuation of this medicine may increase the risk of cardiovascular events. PLAGERINE A 75MG CAPSULE is not recommended for use in patients having severe liver, kidney or lung disease. PLAGERINE A 75MG CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children (below 18 years). Consult your doctor for an alternative therapy. The most common
Uses
OF PLAGERINE A 75MG CAPSULE To manage atherothrombotic events (such as myocardial infarction, stroke, cardiovascular death or refractory ischemia) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion)
How It Works
PLAGERINE A 75MG CAPSULE reduces the risk of heart problems, where clopidogrel acts by irreversibly inhibiting platelet aggregation in the coronary arteries and aspirin acts by blocking an enzyme called cyclo-oxygenase 1 which is believed to be responsible for catalyzing the synthesis of platelets, thus leading to the management of fatal cardiac outcomes.
Directions for Use
Take PLAGERINE A 75MG CAPSULE as advised by your physician. Swallow PLAGERINE A 75MG CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking PLAGERINE A 75MG CAPSULE are diarrhea, nausea, stomach pain and indigestion. Contact your doctor if any of the symptoms worsen. USES OF PLAGERINE A 75MG CAPSULE To manage atherothrombotic events (such as myocardial infarction, stroke, cardiovascular death or refractory ischemia) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion) HOW PLAGERINE A 75MG CAPSULE WORKSPLAGERINE A 75MG CAPSULE reduces the risk of heart problems, where clopidogrel acts by irreversibly inhibiting platelet aggregation in the coronary arteries and aspirin acts by blocking an enzyme called cyclo-oxygenase 1 which is believed to be responsible for catalyzing the synthesis of platelets, thus leading to the management of fatal cardiac outcomes. DIRECTIONS FOR USETake PLAGERINE A 75MG CAPSULE as advised by your physician. Swallow PLAGERINE A 75MG CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF PLAGERINE A 75MG CAPSULECOMMON diarrhea stomach pain indigestion or heartburn UNCOMMON nausea or vomiting headache, dizziness ulcers in the stomach, constipation, flatulence skin rash or itching sensation of tingling and numbness in the body runny nose difficulty in breathing RARE vertigo (spinning sensation) aplastic anemia cramps in lower respiratory tract, asthma attack gynecomastia (breast enlargement in male) menorrhagia (abnormal heavy or prolonged menstrual periods) generalized allergic reactions (such as overall heat sensation with sudden general discomfort until fainting) hemorrhagic vasculitis (inflammation of the blood vessels with bleeding) granulocytosis (increased granulocytes in peripheral blood) decreased platelet count (signs include easy bruising or bleeding) signs of low neutrophil count (sore throat, mouth ulcer or susceptible to infection) Stop taking PLAGERINE A 75MG CAPSULE and contact your doctor immediately if you experience the following side effects: fever, signs of infection or extreme tiredness signs of Thrombotic Thrombocytopenic Purpura (such as jaundice, bruising under the skin that can appear as red pinpoints dots under the skin, confusion, fever, unexplained extreme tiredness and/or confusion) signs of allergic reactions (such as skin rashes, itching with blisters, swelling of the face, lips, mouth, throat or shock) signs of serious skin reactions like erythema multiforme, stevens-johnson syndrome or lyell’s syndrome (such as skin redness with blisters or peeling which may be associated with high fever and joint pain) signs of liver problems (yellowing of the skin or white of the eyes (jaundice), whether not associated with bleeding which appears under the skin (red pinpoint dots) and confusion unusual bleeding (such as bleeding in the brain, bruising under the skin, nasal bleeds, blood in urine, bleeding in the stomach or bowel leading to coughing up blood or black stools or bleeding in other parts of the body such as eyes, lungs or joints)
Warnings & Precautions
& PRECAUTIONSPREGNANCYPLAGERINE A 75MG CAPSULE is not recommended for use during pregnancy. Consult your doctor before taking PLAGERINE A 75MG CAPSULE. BREASTFEEDINGPLAGERINE A 75MG CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking PLAGERINE A 75MG CAPSULE. DRIVING AND USING MACHINESDo not drive or operate any heavy tools or machines if your ability is affected by PLAGERINE A 75MG CAPSULE. ALCOHOLAvoid consumption of alcohol while taking PLAGERINE A 75MG CAPSULE as it could increase the risk of gastrointestinal bleeding. Consult your doctor before taking PLAGERINE A 75MG CAPSULE. KIDNEYPLAGERINE A 75MG CAPSULE is not recommended for use in patients having severe kidney disease and should be used with caution in patients with kidney disease. Consult your doctor before taking PLAGERINE A 75MG CAPSULE. LIVERPLAGERINE A 75MG CAPSULE is not recommended for use in patients having severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking PLAGERINE A 75MG CAPSULE. ALLERGYDo not take PLAGERINE A 75MG CAPSULE if you are allergic to Aspirin, Clopidogrel or any other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, celecoxib, etoricoxib). LUNGSPLAGERINE A 75MG CAPSULE is not recommended for use in patients having respiratory conditions such as asthma, nasal discharge (runny nose) or polyps (a type of growth in the nose). Consult your doctor before taking PLAGERINE A 75MG CAPSULE. OTHERSPLAGERINE A 75MG CAPSULE is not recommended for use if you: have coagulation disorders (Ex. hemophilia, thrombocytopenia) have bleeding in the brain (Ex. intracranial hemorrhage or cerebrovascular hemorrhage) have bleeding in the gastrointestinal tract have gout have menorrhagia (abnormally heavy or prolonged menstrual period) Before taking PLAGERINE A 75MG CAPSULE, inform your physician if you: have stomach ulcer or severe stomach pain had a recent serious injury are going to have any upcoming surgery (including dental procedures) or already had recently had a recent ischemic stroke (blot clot in the artery supplying the brain) have a history of asthma or other allergic diseases are alcoholic have G6PD deficiency (a genetic disorder causing destruction of red blood cells in response to certain stimuli) have active chickenpox or shingles infection Use in pediatrics: PLAGERINE A 75MG CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor for advice. Use in geriatrics: PLAGERINE A 75MG CAPSULE should be used with caution in elderly patients (aged 65 years and above). because of increased risk of gastro-intestinal bleeding and perforation when used for prolonged duration (if prolonged therapy is essential, patients should be
Drug Interactions
SA. Drug-Drug interactions: Before taking PLAGERINE A 75MG CAPSULE inform to your doctor, if you are taking any of these medicines: other anticoagulant medicines used to manage blood clots (Ex. warfarin, heparin, coumarin) or dipyridamole medicines used to manage stomach ulcers such as antacids (Ex. aluminium hydroxide, magnesium hydroxide) and proton-pump inhibitors (Ex. omeprazole or esomeprazole) other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, paracetamol) glycoprotein IIb/IIIa inhibitors (used during percutaneous coronary intervention) Ex. abciximab, eptifibatide and tirofiban medicines used to manage heart problems or hypertension (Ex. captopril, enalapril, lisinopril) selective serotonin reuptake inhibitors (used to manage depression) Ex. fluoxetine, sertraline, paroxetine etc methotrexate (used to manage cancer and other auto immune diseases) diuretics (used to increase urine output) Ex. furosemide, chlorothiazide acetazolamide (used to manage or manage altitude sickness) digoxin (used to manage abnormal heart rate) lithium (used to manage metal illness) corticosteroids (used to manage pain and inflammation) Ex. prednisolone, dexamethasone medicines used to manage epilepsy (Ex. phenytoin, valproic acid) ciclosporin or tacrolimus (used to manage graft rejection or manage auto-immune disease) ticlopidine (an antiplatelet medicine used to manage heart problems) medicines used to manage gout (such as probenecid, sulfinpyrazone or benzbromarone) fluconazole or voriconazole (used to manage fungal infection) medicines used to manage HIV infection (Ex. efavirenz or tenofovir) varicella vaccine (used to manage chickenpox or shingles) moclobemide (a medicine used to manage depression) medicines used to control blood glucose level (Ex. glipizide, gliclazide, glimepiride, repaglinide) paclitaxel (used to manage certain forms of cancer) nicorandil (used to manage chest pain) mifepristone (abortion pill) metoclopramide (used to manage vomiting) Overdosage: If you or anyone else take too much of PLAGERINE A 75MG CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PLAGERINE A 75MG CAPSULE might include increased bleeding, confusion, disorientation, coma, convulsions, vomiting, tinnitus (ringing in the ears), vertigo (spinning sensation), sweating, warm extremities with bounding pulses, increased respiratory rate, hyperventilation, low blood sugar levels, low potassium and platelets levels in blood, increased body temperature, kidney failure, respiratory alkalosis, metabolic acidosis and pulmonary edema (non-cardiac related). SYNOPSIS Drug : Aspirin, Clopidogerl Pharmacological Category : Antiplatelets Therapeutic Indication : Myocardial infarction, Stroke, Cardiac death, Angina Dosage Forms : Tablet, Capsule MORE INFORMATION Keep PLAGERINE A 75MG CAPSULE out of reach of children Store PLAGERINE A 75MG CAPSULE at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
26 Oct 2022