Perinorm Injection 2ml
Key Information
Generic Name
Generic Name Metoclopramide 5 mg
Manufacturer
Ipca Laboratories Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT PERINORM INJECTIONPERINORM INJECTION contains Metoclopramide which belongs to the group of medicines called Anti-emetics. It is indicated for both adults and children (aged 1 to 18 years) to manage nausea and vomiting which may occur after surgery, chemotherapy or radiotherapy. It can also be used to manage nausea and vomiting which is associated with migraine in adults. Migraine is a headache which ca
Uses
severe throbbing pain or pulsing sensation particularly on one
How It Works
PERINORM INJECTION acts and supresses certain centres called dopamine (brain chemical) centres by decreasing the sensitivity of the nerves that transmit signals from gastrointestinal tract to the vomiting centres in the brain. It also relaxes the muscles of stomach and enhances the motility of gut and manages nausea and vomiting.
Directions for Use
PERINORM INJECTION will be given to you only by a doctor or a nurse into a vein as a slow injection (at least 3 minutes) or can be given as an injection into the muscle (intramuscularly). Your doctor will determine the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
receiving PERINORM INJECTION are drowsiness, uncontrollable body movements, diarrhoea, restlessness and feeling weak. Inform your physician immediately if any of the side effect worsens. USES OF PERINORM INJECTION Prevents nausea and vomiting (that occurs after surgery in adults and children) Prevents delayed nausea and vomiting (that occurs after chemotherapy (in children) or caused by radiotherapy (in adults)) Manage nausea and vomiting caused due to migraine (in adults) HOW PERINORM INJECTION WORKSPERINORM INJECTION acts and supresses certain centres called dopamine (brain chemical) centres by decreasing the sensitivity of the nerves that transmit signals from gastrointestinal tract to the vomiting centres in the brain. It also relaxes the muscles of stomach and enhances the motility of gut and manages nausea and vomiting. DIRECTIONS FOR USEPERINORM INJECTION will be given to you only by a doctor or a nurse into a vein as a slow injection (at least 3 minutes) or can be given as an injection into the muscle (intramuscularly). Your doctor will determine the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF PERINORM INJECTIONCOMMON drowsiness uncontrollable movements of the body (such as shaking, tics, twisting movements or muscle stiffness or rigidity) rigidity and tremor (similar to parkinson’s disease) restlessness diarrhoea feeling weak reduced blood pressure UNCOMMON elevated levels of hormone called prolactin (which cause milk secretion in men and women who are not breastfeeding) irregular periods hallucinations decreased consciousness slow heartbeat allergy visual problems and involuntary upward deviation of the eyeball RARE confusion convulsions (fits) especially in patients with a history of epilepsy (seizures) Inform your doctor if you experience any of the following side effects after receiving PERINORM INJECTION: uncontrollable movements (often head or neck) which may occur in children or young adults signs of a brain disorder called neuroleptic malignant syndrome (such as high fever, high blood pressure, convulsions (fits), sweating and production of saliva) signs of severe allergic reactions (such as itching
Warnings & Precautions
& PRECAUTIONSPREGNANCYPERINORM INJECTION is not recommended for use during the first 3 months of pregnancy. It should be used with caution during pregnancy only if considered clearly necessary. Consult your doctor before receiving PERINORM INJECTION. BREASTFEEDINGPERINORM INJECTION is not recommended for use in breastfeeding women as it may pass through the breast milk and affect your baby. Consult your doctor before receiving PERINORM INJECTION. DRIVING AND USING MACHINESDo not drive or operate any machines if you feel dizzy, drowsy or have uncontrollable twitching, jerking or writhing movements, unusual muscle tone leading to distortion of the body or vision problems after receiving PERINORM INJECTION. ALCOHOLAvoid consumption of alcohol while receiving PERINORM INJECTION because it may increase the sedative effects. KIDNEYPERINORM INJECTION should be used with caution in patients having kidney problems. Your doctor may reduce the dose in patients with moderate or severe kidney problems. Consult with your doctor before receiving PERINORM INJECTION. LIVERPERINORM INJECTION should be used with caution in patients having liver problems. Your doctor may reduce the dose in patients with severe liver problems. Consult with your doctor before receiving PERINORM INJECTION. ALLERGYTell your doctor before receiving PERINORM INJECTION if you are allergic to Metoclopramide or any of its constituents. HEART DISEASEPERINORM INJECTION should be used with caution in patients having heart diseases such as history of abnormal heartbeat (QT interval prolongation) or any other heart problems. Consult with your doctor before receiving PERINORM INJECTION. OTHERSPERINORM INJECTION is not recommended for use if you: have bleeding, obstruction or a tear in your stomach or gut have pheochromocytoma (rare tumour of adrenal gland) have involuntary muscle spasms (due to other medicines) have epilepsy (seizures or fits) have parkinson’s disease (brain disorder causing uncontrollable movements of the body) had gastrointestinal surgery (such as pyroplasty) in the last 3 to 4 days have abnormal levels of blood pigments (methemoglobinemia or NADH cytochrome b5 deficiency Before receiving PERINORM INJECTION, inform your doctor if you: have problem with the levels of salts in the blood (such as potassium, sodium or magnesium) have any brain problems are suffering from porphyria (rare inherited blood disorder) Use in paediatrics: PERINORM INJECTION is not recommended for use in children (below 1 year of age) because of the increased risk of uncontrollable movements. It should be used with caution in children and adolescents aged between (1 to 18 years of age). Your child’s doctor may adjust the dose depending upon child’s age and body weight. Consult your child’s doctor for advice. Use in geriatrics: PERINORM INJECTION should be used with caution in elderly patients. Your doctor might adjust your dose depending upon kidney or liver problems and overall health condition. Consult your doctor before receiving PERINORM INJECTION.
Drug Interactions
SA. Drug - Drug interactions: Before receiving PERINORM INJECTION, inform your doctor if you have received or taking any of the following medicines: medicines used to manage a brain disorder called parkinson’s disease (Ex. levodopa, carbidopa) anticholinergics (medicines used to manage stomach cramps and spasms) Ex. dicyclomine, hyoscyamine morphine derivatives (medicine used to manage severe pain) Ex. oxycodone, oxymorphone sedative medicines (used to manage sleeping disorders, anxiety, panic attacks) Ex. diazepam, lorazepam medicines used to manage mental health problems (Ex. quetiapine, risperidone), medicines used to manage depression (Ex. fluoxetine and paroxetine), neuroleptics (used to manage psychiatric disorders or nausea and vomiting) Ex. chlorpromazine medicine used to manage heart failure (Ex. digoxin) ciclosporin (used to manage immune problems) mivacurium and suxamethonium (medicines used to relax the muscles) atovaquone (used to manage pneumonia) medicines used to manage pain (Ex. aspirin, paracetamol) Overdosage: PERINORM INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, inform your doctor if you experience any unusual symptoms such as uncontrollable movements, feeling drowsy, reduced level of consciousness, confusion, hallucinations and cardio-respiratory arrest (loss of function of heart and breathing). SYNOPSIS Drug : Metoclopramide Pharmacological Category : Anti-emetics Therapeutic Indication : Nausea and Vomiting Dosage Forms : Tablet, Capsule, Syrup, Injection MORE INFORMATION Store at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
01 Dec 2022