Pantop LS Capsule 10'S

Ulcerative Colitis/Bowel Inflammatory Disease (115)Rx required

Key Information

Generic Name

Generic Name Levosulpiride 75 mg+Pantoprazole 40 mg

Manufacturer

Aristo Pharmaceuticals Pvt Ltd

Variant

10 Capsule(s) in a Strip

Country of Origin

India

Detailed Information

Introduction

INTRODUCTION ABOUT PANTOP LS CAPSULEPANTOP LS CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANTOP LS CAPSULE is indicated for the short-term management of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone. GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation and inflammation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort. PANTOP LS CAPSULE can also be used to manage peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid). Take PANTOP LS CAPSULE preferably one hour before meals. Avoid consumption of alcohol while taking PANTOP LS CAPSULE as it could potentiate the CNS depressive

Uses

OF PANTOP LS CAPSULE To manage gastro-esophageal reflux disease (GERD) for short-term among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone To manage peptic ulcer and Zollinger-Ellison syndrome

How It Works

PANTOP LS CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.

Directions for Use

Take PANTOP LS CAPSULE as advised by your physician. Swallow PANTOP LS CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTOP LS CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANTOP LS CAPSULE without informing your doctor.

Side Effects

hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors like osteoporosis. Before taking PANTOP LS CAPSULE inform your doctor if you have any liver, kidney or heart problems. PANTOP LS CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children or adolescents (below 18 years of age). PANTOP LS CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). The most common side effects of taking PANTOP LS CAPSULE are nausea, vomiting, headache, dizziness, polyps in the stomach gut and flatulence. Consult your doctor if any of the side effects worsen during or after management with PANTOP LS CAPSULE. USES OF PANTOP LS CAPSULE To manage gastro-esophageal reflux disease (GERD) for short-term among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone To manage peptic ulcer and Zollinger-Ellison syndrome HOW PANTOP LS CAPSULE WORKSPANTOP LS CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions. DIRECTIONS FOR USETake PANTOP LS CAPSULE as advised by your physician. Swallow PANTOP LS CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTOP LS CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANTOP LS CAPSULE without informing your doctor. SIDE EFFECTS OF PANTOP LS CAPSULECOMMON benign polyps in the stomach UNCOMMON headache, dizziness nausea, vomiting stomach pain, diarrhea, flatulence, constipation dry mouth skin rash with eruptions and itching feeling weak, exhausted or generally unwell sleep disturbances fracture of the hip, wrist or spine RARE distortion or complete lack of taste sense blurred vision joint pain, muscle pain changes in weight high fever peripheral edema (swelling of the ankles, legs, feet, arms, or hands) allergic reactions depression breast enlargement in males Stop taking PANTOP LS CAPSULE and contact your doctor immediately if you experience any of the following side effects: signs of decreased magnesium level in blood (such as fatigue, disorientation, involuntary muscle contractions, dizziness, convulsions and increased heart rate) skin rash following sun exposure (Ex. subacute cutaneous lupus erythematosus) sudden unintentional weight loss, recurrent vomiting, blood in vomit which might appear as dark coffee grounds, black, tarry or blood-stained stools, difficulty in swallowing, looking pale, feeling weak, chest pain, stomach pain and severe and/or persistent diarrhea severe allergic reactions (such as skin rash, itching, swelling of the eyes, mouth, tongue and/or throat, difficulty in breathing or swallowing, severe dizziness with very fast heartbeat and heavy sweating) serious skin reactions (such as Stevens-Johnson syndrome, Lyell syndrome or erythema multiforme causing skin rash with swelling, blistering or peeling, losing skin and bleeding around eyes, nose, mouth or genitals with rapid deterioration of general health, or photosensitivity) signs of severe kidney problem (such as acute kidney injury or acute interstitial nephritis causing painful urination, fever, rash, enlarged kidneys and lower back pain) jaundice (yellowing of the skin or whites of the eyes) neuroleptic malignant syndrome (a life-threatening neurologic condition causing altered mental status, high fever, muscle rigidity, irregular pulse, accelerated heartbeat, increased rate of respiration, autonomic nervous system dysfunction resulting in high or low blood pressure, profuse perspiration and excessive sweating) drug-induced movement disorders (tremor, akathisia (unable to stand still))

Warnings & Precautions

& PRECAUTIONSPREGNANCYPANTOP LS CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking PANTOP LS CAPSULE. BREASTFEEDINGPANTOP LS CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking PANTOP LS CAPSULE. DRIVING AND USING MACHINESDo not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANTOP LS CAPSULE. ALCOHOLAvoid consumption of alcohol while taking PANTOP LS CAPSULE, as it may cause additive sedative effects. KIDNEYPANTOP LS CAPSULE is not recommended for use in patients with severe impaired kidney function consult your doctor before taking PANTOP LS CAPSULE. LIVERPANTOP LS CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANTOP LS CAPSULE. ALLERGYDo not take PANTOP LS CAPSULE if you are allergic to Levosulpiride or Pantoprazole. Consult your doctor before taking PANTOP LS CAPSULE. HEART DISEASEPANTOP LS CAPSULE should be taken with caution in patients with cardiovascular disease or a family history of prolonged QT interval. Consult your doctor before taking PANTOP LS CAPSULE. OTHERSPANTOP LS CAPSULE is not recommended for use if you: have phaeochromocytoma (tumors of adrenal gland) have epilepsy have mania or other mental disorders have breast cancer or prolactinoma (a noncancerous tumor of pituitary gland) have gastrointestinal bleeding or obstruction in the gut Before taking PANTOP LS CAPSULE, inform your physician if you: have gastric malignancy (cancers in the gut) have or at risk of developing vitamin B12 deficiency are going to test Chromogranin A level have or at risk of having osteoporosis have a history of cerebrovascular events (stroke, venous thromboembolism) are alcoholic Use in pediatrics: PANTOP LS CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and efficacy data. Consult your child’s doctor for advice. Use in geriatrics: PANTOP LS CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANTOP LS CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function.

Drug Interactions

SA. Drug-Drug interactions: Before taking PANTOP LS CAPSULE inform to your doctor, if you are taking any of these medicines: medicines used to manage fungal infections (such as ketoconazole, itraconazole or posaconazole, amphotericin B) erlotinib (used to manage certain types of cancer) warfarin and phenprocoumon (used to manage or manage thrombotic events and heart problems) medicines used to manage HIV infection (such as atazanavir) methotrexate (a medicine used to manage rheumatoid arthritis, psoriasis or cancer) rifampicin (used to manage tuberculosis) erythromycin and ampicillin esters (used to manage bacterial infections) Ex. hetacillin and pivampicillin iron salts (used to manage anemia) Ex. ferrous sulphate, ferrous fumarate medicine that can neutralize stomach acid such as antacids (Ex. aluminium- and magnesium-hydroxide) or sucralfate anticholinergics (used to relax or reduce the movements of smooth muscles and suppresses body secretions (Ex. atropine, hyoscine) analgesics (used to relieve pain) such as opioids (Ex. methadone) or non-opioids (Ex. naproxen, ibuprofen) sedatives and hypnotics, tranquilizers (used to reduce anxiety and to induce sleep) Ex. alprazolam, chlordiazepoxide, diazepam medicines used to manage depression (Ex. rasagiline, selegiline, phenelzine, haloperidol, imipramine, lithium, fluvoxamine and herbal medicine (St. John’s wort)) medicines used to manage abnormal heart rate (Ex. digitalis, quinine, quinidine, disopyramide, amiodarone, sotalol, flecainide, procainamide) medicines used to manage high blood pressure or other heart problems such as beta-blockers (Ex. propranolol, atenolol) or calcium channel blockers (Ex. verapamil, diltiazem) antipsychotics (used to manage mental illness) Ex. risperidone, paliperidone, amisulpiride, olanzapine, thioridazine non-sedating antihistamines (used to manage allergic symptoms) Ex. fexofenadine, levocetirizine, loratadine antimalarials (used to manage malaria) Ex. quinine, primaquine, halofantrine cisapride (used to manage heartburn and acid reflux) diuretics (used to reduce blood pressure by increasing urine output) Ex. spironolactone, chlorothiazide, acetazolamide corticosteroids (used to manage allergy, pain or inflammation) Ex. dexamethasone, prednisolone stimulant laxatives (used to manage constipation) Ex. bisacodyl pimozide (used to reduce uncontrollable muscle movements) pentamidine (used to manage lung infection) Overdosage: If you or anyone else accidentally take too much of PANTOP LS CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PANTOP LS CAPSULE might include extrapyramidal reactions (such as rigidity, tremor, drooling etc.) or sleep disturbances. SYNOPSIS Drug : Levosulpiride, Pantoprazole Pharmacological Category : Dopamine D2 antagonists, Proton pump inhibitors Therapeutic Indication : GERD, Peptic ulcer, Zollinger-Ellison syndrome Dosage Forms : Tablet, Capsule MORE INFORMATION Keep PANTOP LS CAPSULE out of reach of children Store PANTOP LS CAPSULE at room temperature

Article Information

DW

Written By

DETAILS Written By Dr. R. Dinesh John Rajkumar

Medical Content Writer

DS

Reviewed By

Dr. Sankara Babu Gorle

Medical Expert

Last Updated

02 Dec 2022

Tags

#ulcerative colitis/bowel inflammatory disease (115)#generic name levosulpiride 75 mg+pantoprazole 40 mg