Monotrate OD Tablet 10'S
Key Information
Generic Name
Generic Name Isosorbide Mononitrate 50 mg Also Known As: Isosorbide-5-mononitrate
Manufacturer
Sun Pharmaceutical Industries Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTIONMONOTRATE OD 50MG contains Isosorbide-5-mononitrate which belongs to the group of medicines called nitrate vasodilators. It is used to prevent angina pectoris. Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone. It can also help to control certain types of heart failure. Isosorbide-5-mononitrate works by relaxing the blood vessels of the heart and this reduces the strain on the heart making it easier to pump blood. Along with the management, your doctor might ask you to make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight. The most common
Uses
OF MONOTRATE OD 50MG Prevents angina pectoris
How It Works
After administration, isosorbide-5-mononitrate is converted into free radical nitric oxide which activates the enzyme guanylate cyclase. Activation of this enzyme is followed by synthesis of cyclic guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This process leads to dephosphorylation of myosin light chain of smooth muscles, and results in relaxation and increased blood flow in arteries, veins and cardiac tissue (vasodilatation), this in turn decreases cardiac workload and provides relief from anginal symptoms.
Directions for Use
Take MONOTRATE OD 50MG as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Side Effects
MONOTRATE OD 50MG Prevents angina pectoris HOW MONOTRATE OD 50MG WORKSAfter administration, isosorbide-5-mononitrate is converted into free radical nitric oxide which activates the enzyme guanylate cyclase. Activation of this enzyme is followed by synthesis of cyclic guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This process leads to dephosphorylation of myosin light chain of smooth muscles, and results in relaxation and increased blood flow in arteries, veins and cardiac tissue (vasodilatation), this in turn decreases cardiac workload and provides relief from anginal symptoms. DIRECTIONS FOR USETake MONOTRATE OD 50MG as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. SIDE EFFECTS OF MONOTRATE OD 50MGSERIOUS fainting or collapse increased chest pain COMMON headache nausea or vomiting sleepiness hypotension (low blood pressure) postural hypotension (decreases in blood pressure when standing up) tachycardia (fast heartbeat) dizziness or feeling weak
Warnings & Precautions
& PRECAUTIONSPREGNANCYMONOTRATE OD 50MG should be used with caution in pregnant women. Consult your doctor before taking this medicine. BREASTFEEDINGMONOTRATE OD 50MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine. DRIVING AND USING MACHINESDo not drive or operate any machines, because this medicine may make you feel dizzy or light-headed. ALCOHOLAvoid consumption of alcohol while taking this medicine, because it may raise the blood pressure lowering effect of this medicine. KIDNEYMONOTRATE OD 50MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice. LIVERMONOTRATE OD 50MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice. ALLERGYDo not take this medicine if you are allergic (hypersensitive) to isosorbide-5-mononitrate. HEART DISEASEDo not take this medicine if you are suffering from any heart problems. Discuss the risks and benefits with the doctor. OTHERSDo not take this medicine, if you have: severe anemia, closed angle glaucoma, raised intracranial pressure, cerebral haemorrhage or severe hypovolemia (decreased blood volume) hypothyroidism, hypothermia (low body temperature) or malnourished
Drug Interactions
STalk to your doctor, if you are taking, medicines used to manage high blood pressure ACE-inhibitors (e.g. captopril, enalapril), angiotensin- II-receptor antagonists (e.g. losartan, valsartan), beta-blockers (e.g. propanolol, atenolol), calcium antagonists (e.g. diltizem, verapamil) and diuretic (e.g. furosemide) medicines used to manage male erectile dysfunction (e.g. sildenafil, tadalafil, vardenafil and alprostadil) other medicine used to manage angina such as long acting nitrates (isosorbide dinitrate, nitroglycerin) neuroleptics (used to manage psychiatric disorders) e.g. risperidone, aripiprazole sapropterin (used to lower phenylalanine levels in blood) aldesleukin (used to manage cancer) riociguat (used to manage pulmonary hypertension) tricyclic anti-depressants (used to manage depression) e.g. imipramine, desipramine ergotamine (used for migraine) SYNOPSIS Drug : Isosorbide-5-mononitrate Pharmacological Category : Vasodilators, Anti-anginal agent Therapeutic Indication : Angina pectoris Dosage Forms : Tablet, Capsule MORE INFORMATIONStore below 20-25°C and keep out of reach of children.