MESACOL Suppositories 7's
Key Information
Generic Name
Generic Name Mesalazine 500 mg Also Known As: Mesalamine, 5-Aminosalicylic Acid
Manufacturer
Sun Pharma Laboratories Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT MESACOL SUPPOSITORIES MESACOL SUPPOSITORIES is used to manage gut inflammation and pain associated with ulcerative colitis or ulcerative proctitis. It contains a medicine called Mesalamine (also known as Mesalazine) which when inserted into the rectum, slowly releases the medicine and acts locally to reduce the inflammation and help relieve or stop the pain. MESACOL SUPPOSITORIES is for rectal use only. Carefully follow the instructions advised by your doctor on inserting the medicine. While using mesalamine suppositories, take care to drink plenty of water and fluids as a safety precaution to avoid getting dehydrated easily. Also, make sure to inform your doctor if you are experiencing excessive vomiting, diarrhoea, high fever or any other conditions that can cause severe dehydration. Before using this medicine, inform your doctor if you have liver problems, kidney problems, asthma, any bleeding conditions or if you are pregnant or breastfeeding. The most common
Uses
OF MESACOL SUPPOSITORIESIt is used to provide relief from gut inflammation and pain associated with: Ulcerative colitis Ulcerative proctitis
How It Works
Mesalamine suppository works by reducing inflammation in the lining of the rectum and lower intestine. It is an anti-inflammatory drug that inhibits the production of certain chemicals (prostaglandins and leukotrienes) in the colon, which are involved in causing inflammation, swelling, and tissue damage. By directly targeting the affected area, the suppository form provides localized relief from inflammation, reducing symptoms like rectal bleeding, pain, and diarrhea.
Directions for Use
Empty your bowels before administering MESACOL SUPPOSITORIES Clean your hands thoroughly before and after handling the suppository. Lie down on your left
Side Effects
using MESACOL SUPPOSITORIES are diarrhoea, rectal discomfort, flatulence, stomach pain or headache. These side effects are usually mild, however, consult your doctor if they trouble you. USES OF MESACOL SUPPOSITORIESIt is used to provide relief from gut inflammation and pain associated with: Ulcerative colitis Ulcerative proctitis HOW MESACOL SUPPOSITORIES WORKSMesalamine suppository works by reducing inflammation in the lining of the rectum and lower intestine. It is an anti-inflammatory drug that inhibits the production of certain chemicals (prostaglandins and leukotrienes) in the colon, which are involved in causing inflammation, swelling, and tissue damage. By directly targeting the affected area, the suppository form provides localized relief from inflammation, reducing symptoms like rectal bleeding, pain, and diarrhea. DIRECTIONS FOR USE Empty your bowels before administering MESACOL SUPPOSITORIES Clean your hands thoroughly before and after handling the suppository. Lie down on your left side with your right knee bent toward your chest for easy insertion. Gently insert the pointed end of the suppository into the rectum about 1 inch deep, ensuring it is fully inserted. Stay in a lying position for a few minutes to allow the suppository to dissolve and start working. SIDE EFFECTS OF MESACOL SUPPOSITORIESCommon side effects of MESACOL SUPPOSITORIES: Diarrhoea Abdominal pain Nausea, vomiting Headache Skin rash Flatulence (passing wind) Rectal discomfort Irritation at the site of application Stop using this medicine and inform your doctor immediately if you experience any of the following side effects such as: abdominal pain and cramps, fever, severe headache and rash bloody urine with pain in sides of the abdomen
Warnings & Precautions
& PRECAUTIONSPREGNANCYConsult your doctorThere is only limited information regarding the use of mesalamine during pregnancy. Therefore, consult your doctor for advice before using mesalazine suppositories if you are pregnant or think you may be pregnant. BREASTFEEDINGConsult your doctorThere is only limited information regarding the use of mesalamine during breastfeeding. Available studies indicate the risk of causing allergic reactions such as diarrhea in newborn babies. Therefore, do not take mesalazine suppositories without medical supervision. DRIVING AND USING MACHINESSafeThis medicine is not known to affect the ability to drive and/or use machines. KIDNEYConsult your doctorMESACOL SUPPOSITORIES is not recommended for use in patients with severe kidney problems. It should be used with caution in patients suffering from mild to moderate kidney diseases. LIVERConsult your doctorThis medicine is not recommended for use in patients with severe liver problems. It should be used with caution in patients suffering from mild to moderate liver diseases. ALLERGYContraindicatedTalk to your doctor before using MESACOL SUPPOSITORIES if you are allergic to Mesalamine (or mesalazine) or other salicylates (such as sulphasalazine). LUNGSUse with CautionThis medicine should be used with caution in patients suffering from asthma. USE IN PEDIATRICSContraindicatedMESACOL SUPPOSITORIES is not recommended for use in children aged below 18 years. OTHERSBefore taking this medicine, inform your doctor if you: Are currently prone to bleeding conditions Are dehydrated or suffer from excessive vomiting, diarrhoea or high fever
Drug Interactions
SA. Drug-Drug interactions: Azathioprine (used to minimise the risk of graft rejection) 6-mercaptopurine or thioguanine Anticoagulants (such as warfarin) SYNOPSIS Drug : Mesalamine (or Mesalazine) Pharmacological Category : Salicylates Therapeutic Indication : Ulcerative colitis and proctitis Dosage Forms : Suppositories, tablets, Enema, powder MORE INFORMATIONUlcerative Colitis: Definition: Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the lining of the large intestine (colon) and rectum. The inflammation usually begins in the rectum and may extend into the colon. Symptoms: Abdominal pain and cramping Persistent diarrhea, often with blood or pus Rectal bleeding Urgent need to have a bowel movement Fatigue Weight loss Fever in severe cases Ulcerative Proctitis: Definition: Ulcerative Proctitis is the inflammation of the lining of the rectum, the lower part of the large intestine. It can be a localized form of ulcerative colitis affecting only the rectum. Symptoms: Rectal pain or discomfort A constant feeling of needing to pass stool (tenesmus) Rectal bleeding Mucus discharge from the rectum Diarrhea or constipation Both conditions involve inflammation of the bowel, but proctitis is specifically confined to the rectum, whereas ulcerative colitis can affect a larger portion of the colon. Drug information:
Frequently Asked Questions
Common questions and answers about MESACOL Suppositories 7's.
What is MESACOL SUPPOSITORIES used for?
MESACOL SUPPOSITORIES is used to manage gut inflammation and pain associated with ulcerative colitis or ulcerative proctitis
How do mesalamine suppositories work?
Mesalamine works by reducing inflammation in the rectum by inhibiting the production of inflammatory chemicals like prostaglandins and leukotrienes, providing localized relief.
How often should I use MESACOL SUPPOSITORIES?
Typically, mesalamine suppositories are used once daily at bedtime, or as directed by a doctor. The frequency may depend on the severity of your condition.
How long does it take for MESACOL SUPPOSITORIES to work?
Improvement in symptoms may occur within a few days, but it can take a few weeks for full effects. It’s important to continue using them as prescribed even if you start feeling better.
What are the common side effects of MESACOL SUPPOSITORIES:
The most common side effects of using MESACOL SUPPOSITORIES are diarrhoea, rectal discomfort, flatulence, stomach pain or headache. These side effects are usually mild, however, consult your doctor if they trouble you.
Can I use mesalamine suppositories with other medications?
Mesalamine can generally be used with other medications, but you should inform your doctor about all the drugs and supplements you are taking to avoid interactions.
Are mesalamine suppositories safe during pregnancy?
There is only limited information regarding the use of mesalamine during pregnancy. Therefore, consult your doctor for advice before using mesalazine suppositories if you are pregnant or think you may be pregnant.
Can mesalamine suppositories cure ulcerative colitis or proctitis?
While mesalamine suppositories help manage and control symptoms, they do not cure ulcerative colitis or proctitis. They help maintain remission and reduce flare-ups of inflammation.
Article Information
Written By
DETAILS Written By Srilekha. R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
05 Oct 2024