Luporal Capsule 10'S
Key Information
Generic Name
Generic Name Tegafur 100 mg+Uracil 224 mg
Manufacturer
Lupin Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT LUPORAL CAPSULELUPORAL CAPSULE is a combination of Tegafur and Uracil which belongs to the group of medicines called Thymidylate synthase inhibitors. It is used with calcium folinate to manage metastatic colorectal cancer which is a type of cancer that begins in the colon or rectum and spreads to other parts of the body and characterized by symptoms such as rectal bleeding, narrow stools, persistent abdominal pain and unexplained weight loss. Along with this management, your doctor might advise you for a liver function test to assess the function of your liver. LUPORAL CAPSULE is not recommended for use in patients with severe hepatic impairment, bone marrow suppression from previous radiotherapy or dihydropyrimidine dehydrogenase deficiency disease (a severe neurological disease marked by seizures). Before taking LUPORAL CAPSULE, inform your doctor if you have heart, kidney or liver disease. LUPORAL CAPSULE is not recommended for use in pregnant and breastfeeding women and it is also not recommended for use in children and adolescents (aged below 18 years). This medicine should be used with caution in elderly patients (aged 75 years or above) with age-related impaired kidney, liver or heart function and other concomitant medications or diseases. The most common
Uses
OF LUPORAL CAPSULE Manage metastatic colorectal cancer (in combination with calcium folinate)
How It Works
LUPORAL CAPSULE helps in managing the spread of colorectal cancer cells, where tegafur works by converting into fluorouracil or 5-FU in the liver which causes destruction of cancer cells and uracil works by managing the degradation of 5-FU which results in the prolongation of its stay in the cancer cells thus resulting in the destruction of colorectal cancer cells and managing its spread to other parts of the body.
Directions for Use
Always take this medicine as directed by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your age and disease condition.
Side Effects
taking LUPORAL CAPSULE are nausea, diarrhea, constipation, stomach pain, headache, dizziness and dry skin. Consult your doctor if any of the side effects get worse. USES OF LUPORAL CAPSULE Manage metastatic colorectal cancer (in combination with calcium folinate) HOW LUPORAL CAPSULE WORKSLUPORAL CAPSULE helps in managing the spread of colorectal cancer cells, where tegafur works by converting into fluorouracil or 5-FU in the liver which causes destruction of cancer cells and uracil works by managing the degradation of 5-FU which results in the prolongation of its stay in the cancer cells thus resulting in the destruction of colorectal cancer cells and managing its spread to other parts of the body. DIRECTIONS FOR USEAlways take this medicine as directed by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your age and disease condition. SIDE EFFECTS OF LUPORAL CAPSULECOMMON sore or inflammation inside of the mouth or throat dehydration, weakness anorexia (eating disorder) cachexia (wasting syndrome that leads to loss of skeletal muscle and fat) insomnia, confusion altered taste, taste loss dizziness, headache, sleepiness tingling or numbness sensation shedding tears, conjunctivitis breathlessness, increased coughing diarrhoea, abdominal pain nausea, vomiting constipation, flatulence indigestion, burping dry mouth hair loss, dry skin, nail disorder rash, itching, skin discoloration joint, muscle or back pain peripheral oedema, general discomfort fever, chills, pain weight loss UNCOMMON irregular heartbeat heart attack or arrest inflammation of the lining of the stomach, intestine or ileum jaundice (yellowing of skin or white of the eyes) urinary retention, blood in urine impotence chest pain RARE loss or distorted sense of smell interstitial pneumonia fatigue
Warnings & Precautions
& PRECAUTIONSPREGNANCYLUPORAL CAPSULE is not recommended for use in pregnant women or those who are attempting to become pregnant. Consult your doctor before taking LUPORAL CAPSULE. BREASTFEEDINGLUPORAL CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking LUPORAL CAPSULE. DRIVING AND USING MACHINESLUPORAL CAPSULE should be used with caution while driving or operating machines since it might cause confusion. Consult your doctor before taking LUPORAL CAPSULE. ALCOHOLAvoid or limit consumption of alcohol while taking LUPORAL CAPSULE. KIDNEYLUPORAL CAPSULE should be used with caution in patients with impaired renal function. Consult your doctor before taking LUPORAL CAPSULE. LIVERLUPORAL CAPSULE is not recommended for use in patients with severe hepatic impairment and deficiency of hepatic gene called CYP2A6 (gene responsible for drug metabolism). It should be used with caution in patients with mild to moderate liver dysfunction. Consult your doctor before taking LUPORAL CAPSULE. ALLERGYLUPORAL CAPSULE is not recommended for use if you are allergic to 5-FU (flouroracil), tegafur, uracil or any other ingredients of this medicine. HEART DISEASELUPORAL CAPSULE should be used with caution in patients with heart disease such as myocardial ischaemia (low blood flow to heart), angina (chest pain) or myocardial infarction (heart attack). Consult your doctor before taking LUPORAL CAPSULE. OTHERSLUPORAL CAPSULE is not recommended for use if you: have bone marrow suppression (a condition of low blood cells) from previous radiotherapy (a cancer therapy that uses radiation to shrink tumors and kill cancer cells) have dihydropyrimidine dehydrogenase deficiency disease (a severe neurological disease marked by seizures Before taking LUPORAL CAPSULE, inform your doctor if you: signs and symptoms of bowel obstruction Use in Pediatrics: LUPORAL CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice. Use in Geriatrics: LUPORAL CAPSULE should be used with caution in elderly patients (aged 75 years or above) with age-related impaired kidney, liver or heart function and other concomitant medications or diseases. Consult your doctor before taking LUPORAL CAPSULE.
Drug Interactions
SA. Drug-Drug Interactions: Before taking LUPORAL CAPSULE, inform your doctor, if you are taking any of the following medicines: medicines that inhibit dihydropyrimidine dehydrogenase (an enzyme responsible for breaking down thymine and uracil which forms a structure of gene) Ex. brivudine cytotoxic agents such as cyclophosphamide, busulfan and bleomycin (used to manage cancer) warfarin (used to manage blood clotting) phenytoin (used to control certain type of seizures during or after surgery) coumarin (used in the management of prostate cancer, kidney cancer) methoxypsoralen (medicine used to manage psoriasis and vitiligo) medicines used to manage fungal infections Ex. clotrimazole, ketoconazole and miconazole Overdosage: If you or anyone else accidentally takes too much of LUPORAL CAPSULE, consult your doctor immediately or visit the nearby hospital. Overdose symptoms of LUPORAL CAPSULE are nausea, vomiting, diarrhea, stomach ulcers, bleeding and bone marrow suppression (a condition of low blood cells). SYNOPSIS Drug : Tegafur, Uracil Pharmacological Category : Thymidylate synthase inhibitors Therapeutic Indication : Metastatic colorectal cancer Dosage Forms : Capsule MORE INFORMATION Keep the medicine out of reach of children Store LUPORAL CAPSULE at room temperature
Article Information
Written By
ity (HPRA). [Revised in August 2010] [Accessed on 16th May 2022] https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0654-017-001_09082010151841.pdf USEFUL DIAGNOSTIC TESTS Colonoscopy Biomarker testing of the tumor AUTHOR DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
17 Dec 2022