LENVATOL 10 Capsule 10's
Key Information
Generic Name
Generic Name Lenvatinib 10 mg
Manufacturer
Cipla Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT LENVATOL 10 CAPSULELENVATOL 10 CAPSULE contains Lenvatinib which belongs to the group of medicines called Antineoplastic agents. LENVATOL 10 CAPSULE is used on its own to manage locally recurrent/metastatic thyroid cancer in adults when radioactive iodine management becomes insufficient to stop the disease. LENVATOL 10 CAPSULE is also used on its own to manage liver cancer (hepatocellular carcinoma) when it becomes unresectable in adult patients. It is also used together with pembrolizumab (anticancer medicine) to manage endometrial carcinoma when cancer has spread and cannot be managed by surgery/radiation management. The medicine is also indicated for use in combination with everolimus (anticancer medicine) to manage advanced renal cell carcinoma (kidney cancer) in adults prior to anti-angiogenic therapy (cancer therapy). LENVATOL 10 CAPSULE is not recommended for use in patients allergic to Lenvatinib. Before taking LENVATOL 10 CAPSULE, inform your doctor if you have high blood pressure, aneurysm (enlargement and weakening of blood vessel wall), history of blood clots in your arteries, heart diseases (such as congestive heart failure, heart attack), kidney diseases (such as mild/moderate/severe renal impairment), and/or liver diseases (such as mild/moderate/severe hepatic impairment). LENVATOL 10 CAPSULE is generally not recommended for use during pregnancy unless it is clearly necessary. It is also not recommended for use in breastfeeding women. LENVATOL 10 CAPSULE is not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years/above) after consulting the doctor. The most common
Uses
OF LENVATOL 10 CAPSULE Manage locally recurrent/metastatic thyroid cancer in adult patients. Manage unresectable liver cancer (hepatocellular carcinoma) Manage advanced endometrial carcinoma when used with pembrolizumab (anticancer medicine) in adults in whom the cancer has spread and cannot be removed by surgery/radiation management. Manage advanced renal cell carcinoma (kidney cancer) when used in combination with everolimus (anticancer medicine) following prior anti-angiogenic therapy in affected individuals
How It Works
LENVATOL 10 CAPSULE works by inhibiting the action of receptor tyrosine kinases (proteins responsible for development of new blood vessels) which leads to poor oxygen and nutrient supply to the cancer cell resulting in its destruction thus managing cancer in affected individuals.
Directions for Use
Take LENVATOL 10 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking LENVATOL 10 CAPSULE are nausea, redness, rashes, peeling of skin, weight loss, vomiting, and/or hoarseness of voice. Consult your doctor if any of these symptoms worsen. USES OF LENVATOL 10 CAPSULE Manage locally recurrent/metastatic thyroid cancer in adult patients. Manage unresectable liver cancer (hepatocellular carcinoma) Manage advanced endometrial carcinoma when used with pembrolizumab (anticancer medicine) in adults in whom the cancer has spread and cannot be removed by surgery/radiation management. Manage advanced renal cell carcinoma (kidney cancer) when used in combination with everolimus (anticancer medicine) following prior anti-angiogenic therapy in affected individuals HOW LENVATOL 10 CAPSULE WORKSLENVATOL 10 CAPSULE works by inhibiting the action of receptor tyrosine kinases (proteins responsible for development of new blood vessels) which leads to poor oxygen and nutrient supply to the cancer cell resulting in its destruction thus managing cancer in affected individuals. DIRECTIONS FOR USETake LENVATOL 10 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF LENVATOL 10 CAPSULECOMMON high/low blood pressure muscle pain, feeling unwell with body pain dizziness, tiredness, weakness bleeding (most commonly nose bleeds) signs of blood clots in the lungs such as difficulty breathing, chest pain signs of decreased red blood cells such as weakness, dizziness, chest pain pounding/racing heartbeat reduced appetite/weight loss nausea, vomiting, constipation, stomach pain, diarrhoea, indigestion hoarse voice swelling of the legs rash dry/sore/inflamed mouth loss of proper taste sensation joint pain, back pain headache, hair loss difficulty in sleeping signs of palmar-plantar erythrodysesthesia (hand-foot syndrome) such as swelling, redness and soreness of skin on hands and feet signs of underactive thyroid such as weight gain, tiredness, constipation, dry skin, feeling cold signs of decreased count of white blood cells such as body aches, chills, fever and headaches. signs of reduced platelets count such as bruising and delayed wound healing signs of increased amylase and lipase levels in blood such as ulcer, pancreatitis (inflammation of pancreas) dehydration dry skin, itching and thickening of the skin feeling bloated or having excess wind signs of liver failure such as dizziness, loss of sleep, confusion, decreased concentration, loss of consciousness inflammation of the gallbladder signs of stroke such as feeling numb or weak on one side of your body, severe headache, seizure, confusion, difficulty talking, vision changes or feeling dizzy anal fistula (a small channel between the anus and surrounding skin) signs of urinary infections such as increased frequency in urination and pain in passing urine UNCOMMON painful infection and irritation near the anus signs of heart problems such as chest pain/pressure, pain in arms, back, neck/ jaw, shortness of breath, rapid/ irregular heart rate, coughing, bluish color of lips/fingers, and feeling very tired mini stroke damage to the liver signs of splenic infarction (condition marked by poor blood supply to spleen) such as chills, fever, nausea and pain in the upper left part of the abdomen signs of inflammation of the pancreas such as upper abdominal pain, fever, fast pulse problems in wound healing osteonecrosis (damage to the bones in jaw) RAREStop taking LENVATOL 10 CAPSULE and contact your doctor if you experience any of the following side effects: signs of stroke such as feeling weak or numb on one side of the body, severe headache, seizure, confusion, visual disturbances, dizziness, severe increase in blood pressure, signs of heart problems such as chest pain/pressure, pain in arms/back/ neck/jaw, shortness of breath, rapid/irregular heartbeat, coughing, bluish lips or fingers, tiredness signs of lung problems such as blood clot in lungs, inability of the lungs to inflate due to leak of air from lungs into chest signs of fistula in gut such as severe pain in the belly signs of bleeding such as coughing up blood, black, tarry or bloody stools, severe and persistent nose bleeds, blood in urine, vomiting blood, heavy/new onset vaginal bleeding signs of liver problems (grade 3 liver impairment) such as yellow skin or yellowing of the whites of the eyes, drowsiness, confusion, poor concentration signs of dehydration leading to kidney failure such as serious diarrhoea, nausea, and vomiting signs of osteonecrosis (death of bone tissue due to lack of blood supply) such as pain in the mouth, teeth or jaw, swelling/sores inside the mouth, numbness or feeling of heaviness in the jaw, loosening teeth life threatening consequences such as malignant hypertension (high blood pressure) asthenia (weakness) signs of nephrotic syndrome (kidney disorder marked by high protein in urine) such as edema, weakness, loss of appetite signs of arterial thromboembolism (serious disorder marked by blood clot in artery) such as cold arm, pain in affected area, weakness of arm or leg sign of reversible posterior leukoencephalopathy syndrome (rare condition marked by swelling of brain) such as severe headache, weakness, fits, confusion, visual problems heart failure, heart attack signs of kidney failure and impairment such as decreased urine output, shortness of breath, weakness
Warnings & Precautions
& PRECAUTIONSPREGNANCYLENVATOL 10 CAPSULE is generally not recommended for use during pregnancy unless it is clearly necessary. If you become pregnant while taking LENVATOL 10 CAPSULE, consult your doctor immediately who may advise you to use a barrier method of contraception to manage pregnancy which may be advised to be continued next one month after stopping the management with LENVATOL 10 CAPSULE. BREASTFEEDINGLENVATOL 10 CAPSULE is generally not recommended for use in breastfeeding women as it may pass through the breast milk and may seriously harm the breastfed baby. Consult your doctor before taking [GBNKEWORD]. DRIVING AND USING MACHINESDo not drive or operate any machines if you feel dizzy or tired after taking LENVATOL 10 CAPSULE. KIDNEYLENVATOL 10 CAPSULE should be used with caution in patients with kidney disease such as mild, moderate/severe renal impairment. Consult your doctor before taking the medicine. LIVERLENVATOL 10 CAPSULE should be used with caution in patients with liver problems such as mild, moderate/severe hepatic impairment. Consult your doctor before taking the medicine. ALLERGYDo not take LENVATOL 10 CAPSULE if you are allergic to Lenvatinib, and/or any other ingredients in the medicine. HEART DISEASELENVATOL 10 CAPSULE should be used with caution in patients with heart disease such as congenital long QT syndrome, congestive heart failure, heart attack, stroke, bradyarrhythmia. Consult your doctor before taking the medicine. OTHERSBefore taking LENVATOL 10 CAPSULE, inform your doctor if you: have or had an aneurysm (enlargement and weakening of blood vessel wall) or a tear in a blood vessel wall. have high blood pressure have history of blood clots in your arteries have a history of a tear (perforation) in your stomach or intestine have recently undergone radiotherapy/surgery are scheduled for a major surgery or dental management weigh less than 60kg had a history of fistula (abnormal connection between organs) have or had pain in the mouth, teeth and/or jaw, swelling/sores inside the mouth, numbness/ feeling of heaviness in the jaw, and/or loosening of a tooth. have bleeding problems have fits, vision problems or headache Use in Pediatrics: LENVATOL 10 CAPSULE is not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking the medicine. Use in Geriatrics: LENVATOL 10 CAPSULE should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking LENVATOL 10 CAPSULE
Drug Interactions
SA. Drug - Drug interactions: Before taking LENVATOL 10 CAPSULE, inform your doctor if you are taking any of the following medicine: carboplatin, paclitaxel (used to manage ovarian cancer) midazolam (used to relieve anxiety before surgery or certain procedures) oral contraceptives (used to manage pregnancy) Ex. desogestrel and ethinyl estradiol antiresorptive medicines (used to manage osteoporosis) Ex. alendronate, risedronate angiogenesis inhibitors (used to block growth of blood vessels) Ex. axitinib, bevacizumab Overdosage: If you or anyone else accidentally took more of LENVATOL 10 CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypertension, nausea, diarrhoea, fatigue, stomatitis (inflammation and soreness of mouth), proteinuria (increased concentration of protein in urine), and/or headache. SYNOPSIS Drug : Lenvatinib Pharmacological Category : Kinase inhibitor Therapeutic Indication : Differentiated thyroid carcinoma, Endometrial carcinoma, Hepatocellular carcinoma, Advanced renal cell carcinoma Dosage Forms : Capsule MORE INFORMATION Keep LENVATOL 10 CAPSULE out of reach of children Do not store LENVATOL 10 CAPSULE above 25°C
Article Information
Written By
DETAILS Written By Dr. K .AZEEM HUSSAIN
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
03 Dec 2022