Hansepran 50mg Capsule 10'S
Key Information
Generic Name
Generic Name Clofazimine 50 mg
Manufacturer
Abbott Healthcare Pvt Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTIONHANSEPRAN 50MG contains Clofazimine which belongs to the group of medicines called Antimycobacterial agents. It is used to manage lepromatous leprosy (including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum) in combination with other anti-leprosy drugs. Leprosy is a chronic and contagious infection caused by mycobacterium leprae which affects the skin, nerves out
Uses
OF HANSEPRAN 50MGUsed in combination with other anti-leprosy drugs to manage: lepromatous leprosy dapsone-resistant lepromatous leprosy lepromatous leprosy complicated by erythema nodosum leprosum
How It Works
HANSEPRAN 50MG induces membrane dysfunction in the bacterial cell which also works by blocking the production of certain cells (responsible for causing inflammation) in the body that results in destruction of bacterial cell and prevention of inflammatory reaction in the body thus helps to manage lepromatous leprosy and its associated symptoms.
Directions for Use
Take HANSEPRAN 50MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
HANSEPRAN 50MG are reversible reddish dark-brown discolouration of skin, hair and eyes, discolouration of body fluids (such as sweat, saliva, tears, urine, and stools), abdominal pain, diarrhoea, nausea, vomiting and dryness of skin. Consult your doctor if any of the symptom worsens. USES OF HANSEPRAN 50MGUsed in combination with other anti-leprosy drugs to manage: lepromatous leprosy dapsone-resistant lepromatous leprosy lepromatous leprosy complicated by erythema nodosum leprosum HOW HANSEPRAN 50MG WORKSHANSEPRAN 50MG induces membrane dysfunction in the bacterial cell which also works by blocking the production of certain cells (responsible for causing inflammation) in the body that results in destruction of bacterial cell and prevention of inflammatory reaction in the body thus helps to manage lepromatous leprosy and its associated symptoms. DIRECTIONS FOR USETake HANSEPRAN 50MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF HANSEPRAN 50MGCOMMON discolouration of lining of the eyelids and body fluids such as sweat, sputum, saliva, tears, urine and stools reversible reddish/pink to dark brown, black discolouration of the skin, hair and eyes upper abdominal pain diarrhoea nausea vomiting food intolerance scaling and dryness of skin rashes itching pigmentation in eyes dryness, burning, itching or irritation in eyes high blood sugar levels signs of elevated erythrocyte sedimentation rate (ESR) such as increased frequency of infections disturbed eyesight weight loss UNCOMMON headache loss of appetite increased skin sensitivity to sunlight skin reactions such as acneiform eruptions (condition marked by acne like bumps eruption) tiredness swollen lymph nodes dizziness constipation jaundice (yellowish discoloration of the eyes and skin) fever erythroderma (inflammation of skin surface) monilial cheilosis (fungal infection at the angles of the mouth) anorexia (an eating disorder causing weight gain or weight loss) eosinophilic enteritis (rare inflammatory disorder of intestinal wall) maculopathy (an eye disorder) drowsiness giddiness neuralgia (pain at path of the nerve) taste disturbance splenic infarction (impaired blood supply to spleen) thromboembolism (blood clots causing blockage in blood vessels) anaemia (reduced blood cell count) cystitis (inflammation of urinary bladder) bone pain oedema (swelling in hands and feet caused by water retention) signs of vascular pain such as heaviness/pain in the vascular disease/injury area RAREStop taking HANSEPRAN 50MG and contact your doctor if you experience any of the following side effects: skin rash signs of liver damage such as severe nausea, vomiting, abdominal pain, bloody or black tarry stools and yellow eyes or skin signs of heart rhythm disturbances such as irregular heartbeat, dizziness, fainting, shortness of breath and severe tiredness upper stomach pain accompanied by fever, chills, chest, left shoulder pain, nausea and vomiting blurred or cloudy vision bowel obstruction signs of bleeding in stomach and intestine such as black stools signs of hepatitis such as feeling unwell, nausea, vomiting, a loss of appetite, and fever serious skin reactions such as flaking and peeling of skin severe dryness, burning, itching, or irritation in eyes severe eyesight problems severe skin rash and itchiness extreme weight loss depression due to skin discoloration
Warnings & Precautions
& PRECAUTIONSPREGNANCYHANSEPRAN 50MG should be used with caution in pregnant women and in women planning for pregnancy only if it is considered clearly necessary. Consult your doctor before taking HANSEPRAN 50MG. BREASTFEEDINGHANSEPRAN 50MG is not recommended for use in breastfeeding women as it may pass through milk. Consult your doctor before taking HANSEPRAN 50MG. DRIVING AND USING MACHINESDo not drive or operate any machines while taking HANSEPRAN 50MG as this medicine can cause dizziness, tiredness, headache and/or eyesight problems. Consult your doctor before taking HANSEPRAN 50MG. KIDNEYHANSEPRAN 50MG should be used with caution in patients with kidney problems. Consult your doctor before taking HANSEPRAN 50MG. LIVERHANSEPRAN 50MG should be used with caution in patients with liver problems such as hepatitis B or C (liver infection). Consult your doctor before taking HANSEPRAN 50MG. ALLERGYHANSEPRAN 50MG is not recommended for use if you are allergic to clofazimine, peanuts, soya, or any other ingredients of this medicine. HEART DISEASEHANSEPRAN 50MG is not recommended for use if you have a personal or family history of heart problem such as congenital long QT syndrome (heart rhythm disorder). It should be used with caution in patients with other heart problems. Consult your doctor before taking HANSEPRAN 50MG. OTHERSBefore taking HANSEPRAN 50MG, inform your doctor if you have: frequent stomach pain continuous diarrhoea or vomiting Use in Paediatrics: HANSEPRAN 50MG is recommended for use in children and adolescents (aged 10 to 14 years). It should be used with caution in children (aged below 10 years) after consulting the doctor who might decide the dosage based on child’s age, body weight and disease condition. Use in Geriatrics: HANSEPRAN 50MG should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking HANSEPRAN 50MG.
Drug Interactions
SA. Drug-Drug Interactions Before taking HANSEPRAN 50MG, inform your doctor, if you are taking any of the following medicines: other medicines used to manage leprosy Ex. dapsone medicines used to manage tuberculosis and leprosy Ex. rifampicin, isoniazid, bedaquiline and delamanid azithromycin, clarithromycin and fluoroquinolones such as levofloxacin (used to manage bacterial infections) amprenavir, delaviridine, efavirenz, etravirine, indinavir, nelfinavir, raltegravir, rilpivirine, simeprevir, maraviroc (used to manage HIV infection) medicines to lower blood cholesterol levels Ex. simvastatin, lovastatin medicines used to manage high blood pressure Ex. losartan, verapamil, diltiazem, nitrendipine, amlodipine, nislodipine, nifedipine, eplerenone, felodipine, lercanidipine medicines to reduce blood sugar levels Ex. pioglitazone, repaglinide, saxagliptin phenytoin, fosphenytoin (used to control seizures) Overdosage: If you or anyone else accidentally takes too much of HANSEPRAN 50MG, consult your doctor immediately or visit the nearby hospital if you experience any unusual symptoms. SYNOPSIS Drug : Clofazimine Pharmacological Category : Antimycobacterial agent Therapeutic Indication : Lepromatous leprosy Dosage Forms : Capsule MORE INFORMATION Keep HANSEPRAN 50MG out of reach of children Store HANSEPRAN 50MG at room temperature
Article Information
Written By
ity (SAHPRA) [Revised in November 2019] [Assessed on 3rd August 2022] https://www.sahpra.org.za/wp-content/uploads/2020/06/Lamprene_PIL_Novartis_MCC-Format04-November-2019.pdf USEFUL DIAGNOSTIC TESTS Skin biopsy Nerve biopsy
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