Espanz D Capsule 10'S
Key Information
Generic Name
Generic Name DOMPERIDONE+ESOMEPRAZOLE
Manufacturer
Icarus Health Care Pvt Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT ESPANZ D CAPSULEESPANZ D CAPSULE is a combination of Domperidone and Esomeprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. It is used in adults to manage peptic ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid). Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus and/or intestines. It ca
Uses
severe stomach pain with sensation of flatulence, indigestion, vomiting and fatigue. ESPANZ D CAPSULE is effective in managing peptic ulcer caused either due to stomach infection (H. pylori infection) or due to prolong use of non-steroidal anti-inflammatory drugs (such as ibuprofen, Aceclofenac etc.). It can also be used to manage re-bleeding from the ulcers. GERD is a chronic digestive disease in which the acid from the stomach frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort. ESPANZ D CAPSULE acts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn. ESPANZ D CAPSULE should be taken at least 30 minutes before meals. During management with ESPANZ D CAPSULE your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted
How It Works
ESPANZ D CAPSULE contains two medicines namely domperidone and esomeprazole. Domperidone is a prokinetic medicine with anti-emetic properties. It works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and the brain which reduces the onset of nausea and vomiting. Esomeprazole is a proton pump inhibitor. It reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, ESPANZ D CAPSULE manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).
Directions for Use
Take ESPANZ D CAPSULE 30 minutes to 1 hour before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ESPANZ D CAPSULE unless your doctor advice you to stop.
Side Effects
taking ESPANZ D CAPSULE are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you. You must also inform your doctor immediately if you experience any abnormal signs such as unusual tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat, fragile bones, bloody stools or vomits or sudden weight loss. USES OF ESPANZ D CAPSULEIt is used in adults to manage: Peptic ulcers Gastrointestinal Reflux disease (GERD) Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid) Nausea and Vomiting Acidity, Heartburn, Indigestion, Burping, Bloating HOW ESPANZ D CAPSULE WORKSESPANZ D CAPSULE contains two medicines namely domperidone and esomeprazole. Domperidone is a prokinetic medicine with anti-emetic properties. It works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and the brain which reduces the onset of nausea and vomiting. Esomeprazole is a proton pump inhibitor. It reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, ESPANZ D CAPSULE manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion). DIRECTIONS FOR USETake ESPANZ D CAPSULE 30 minutes to 1 hour before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ESPANZ D CAPSULE unless your doctor advice you to stop. SIDE EFFECTS OF ESPANZ D CAPSULECOMMON headache diarrhea, stomach pain, constipation, flatulence nausea, vomiting benign polyps in the stomach UNCOMMON dry mouth low sex drive dizziness, drowsiness anxiety, sleeplessness skin rash or itchiness breast enlargement in both men and in women feeling weak swelling of body parts (oedema) fragile bones (risk of bone fracture) abnormal liver function tests RARE low WBC or platelet counts in blood signs of low sodium levels in blood (weakness, being sick and cramps) mouth ulcers hair loss fungal infection of the gut (thrush) Stop taking ESPANZ D CAPSULE and inform your doctor immediately if you experience any of the following side effects such as: severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing) signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness) severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever) chest pain, fast or irregular heartbeat, difficulty in breathing, feeling faint fits uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat) skin rashes on sun exposed areas with or without joint pain sudden weight loss, looking pale and weak (anemia) signs of bleeding in the gut (such as bloody vomits/stools)
Warnings & Precautions
& PRECAUTIONSPREGNANCYESPANZ D CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it. BREASTFEEDINGESPANZ D CAPSULE may pass through breast milk. Therefore, it is not recommended for use in breastfeeding women unless considered necessary by the physician. DRIVING AND USING MACHINESESPANZ D CAPSULE does not affect your ability in driving or handling heavy tools or machines. However, do not drive or handle heavy tools or machines if your ability is affected by ESPANZ D CAPSULE. ALCOHOLAvoid consumption of alcohol while taking ESPANZ D CAPSULE, as it could aggravate your existing condition. KIDNEYESPANZ D CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it. LIVERESPANZ D CAPSULE is not recommended for use in patients with moderate or severe liver impairment. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it. ALLERGYDo not take ESPANZ D CAPSULE if you are allergic to Domperidone, Esomeprazole or to any other proton pump inhibitors (such as rabeprazole, pantoprazole). HEART DISEASEESPANZ D CAPSULE is not recommended for use in patients having heart problems (such as prolongation of QT wave, congestive heart failure or arrhythmia). Therefore, consult your doctor before taking it. OTHERSESPANZ D CAPSULE is not recommended for use if you: have bloody stools or bleeding in the gut have blockage or tear in the intestines have severe fluid or electrolyte disturbances have prolactinoma (a non-cancerous tumor of pituitary gland) have low blood potassium or magnesium levels have hyperkalemia (high blood potassium levels) Before taking ESPANZ D CAPSULE inform your doctor if you: have osteoporosis have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression) are going to test Chromogranin A level Use in pediatrics: ESPANZ D CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. However, consult your doctor before taking it. Use in geriatrics: ESPANZ D CAPSULE should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it.
Drug Interactions
SA. Drug-Drug interactions: Before taking ESPANZ D CAPSULE inform your doctor if you are taking any of the following medicines such as: other medicines used to manage gastrointestinal problems (Ex. cisapride, dolasetron, prucalopride, diphemanil, bepridil, methadone, omeprazole, lansoprazole, rabeprazole, ranitidine, famotidine) medicines used to manage arrhythmia or other heart problems (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem, or verapamil) medicines used to manage HIV infection (Ex. atazanavir, nelfinavir, saquinavir) antipsychotics (used to manage mental illness) Ex. haloperidol, pimozide, sertindole antidepressants (used to manage depression) Ex. escitalopram, citalopram, imipramine, St. John’s Wort antibiotics (used to manage bacterial infections) Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin, or amoxicillin medicines used to manage malaria (Ex. halofantrine, lumefantrine) antihistamines (used to manage allergies) Ex. mizolastine, mequitazine medicines used to manage cancer (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib) methotrexate (used to manage cancer and auto-immune disease) tacrolimus (used to manage graft rejection) ketoconazole, itraconazole or voriconazole (used to manage fungal infection) rifampicin (used to manage tuberculosis) apomorphine (used to manage Parkinson’s disease) diazepam (used to manage anxiety) phenytoin (used to manage epilepsy) cilostazol (used to manage pain in legs) warfarin (used for blood thinning) clopidogrel (used to manage or manage blood clots) B. Drug-Food interaction: Try to take this medicine before meals to achieve maximum efficacy. Overdosage: If you or anyone else accidentally took more ESPANZ D CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal posture. SYNOPSIS Drug : Domperidone, Esomeprazole Pharmacological Category : Dopamine antagonist, Proton-pump inhibitor Therapeutic Indication : GERD, Peptic ulcer, Zollinger-Ellison syndrome, Acidity, Heartburn, Indigestion Dosage Forms : Tablet, Capsule MORE INFORMATION Keep ESPANZ D CAPSULE out of the sight and reach of children Store ESPANZ D CAPSULE at room temperature
Article Information
Written By
DETAILS Written By Srilekha. R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
05 Nov 2022