ESIUM L Capsule 10's
Key Information
Generic Name
Generic Name Esomeprazole 40 mg+Levosulpride 75 mg
Manufacturer
TAS MED INDIA PVT LTD
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT ESIUM L CAPSULEESIUM L CAPSULE is a combination of Esomeprazole and Levosulpiride which belongs to the group of medicines called Proton-pump inhibitors and Dopamine D2 antagonists respectively. ESIUM L CAPSULE is indicated for the management of Gastro-esophageal reflux disease (GERD) among patients who do not adequately respond to proton-pump inhibitors alone (Ex. pantoprazole, rabeprazole, esomeprazole, omeprazole). GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort. ESIUM L CAPSULE can also be used to manage peptic ulcer caused by H. pylori infection or NSAID use. Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue. Along management with ESIUM L CAPSULE eat less spicy food and drink plenty of water or fluids as advised by your physician. Avoid consumption of alcohol as it could aggravate your existing disease conditions. Patients receiving long-term management with ESIUM L CAPSULE should be kept on regular surveillance to rule out the risk of bone fractures (hip, wrist or spine), predominantly in patients taking corticosteroids and in patients with other recognized risk factors like osteoporosis. Before taking ESIUM L CAPSULE, inform your doctor if you have any heart, kidney or liver disease as a precaution. ESIUM L CAPSULE is not recommended for use in pregnant or breastfeeding women, including children and adolescents (aged below 18 years) due to lack of safety and effectiveness. ESIUM L CAPSULE should be used with caution in elderly patients (aged 65 years or above). The most common
Uses
OF ESIUM L CAPSULE Manage Gastro-esophageal reflux disease (GERD) among patients who do not respond to proton-pump inhibitors (Ex. pantoprazole, rabeprazole, esomeprazole, omeprazole) alone Manage peptic ulcer
How It Works
ESIUM L CAPSULE reduces peptic ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by blocking the dopamine D2 receptors in the gut which promotes the secretions of acetylcholine, thus facilitating gastric emptying and healing of ulcers and/or esophageal lesions.
Directions for Use
Take ESIUM L CAPSULE as advised by your physician. Swallow ESIUM L CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking ESIUM L CAPSULE are headache, nausea, vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of the side effects worsen. USES OF ESIUM L CAPSULE Manage Gastro-esophageal reflux disease (GERD) among patients who do not respond to proton-pump inhibitors (Ex. pantoprazole, rabeprazole, esomeprazole, omeprazole) alone Manage peptic ulcer HOW ESIUM L CAPSULE WORKSESIUM L CAPSULE reduces peptic ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by blocking the dopamine D2 receptors in the gut which promotes the secretions of acetylcholine, thus facilitating gastric emptying and healing of ulcers and/or esophageal lesions. DIRECTIONS FOR USETake ESIUM L CAPSULE as advised by your physician. Swallow ESIUM L CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF ESIUM L CAPSULECOMMON headache nausea or vomiting diarrhea, stomach pain, constipation, flatulence benign polyps in stomach UNCOMMON swollen ankles and feet insomnia (lack of sleep) dizziness pins and needles (tingling sensation in the body) sleepiness vertigo (spinning sensation) dry mouth skin rash, lumpy rash (hives) and itching fracture of wrist, hip or spine RARE agitation, confusion, depression, aggression blurred vision changes in taste bronchospasm (difficulty in breathing) mouth sores fungal infection (Ex. thrush) hair loss skin sensitivity (skin rash following sun exposure) joint pain or muscle pains tiredness or lack of energy increased sweating abnormal heart rhythm Stop taking ESIUM L CAPSULE and contact your doctor immediately if you experience the following side effects: signs of severe allergic reactions (such as skin rash, sudden wheezing, swelling of the lips, tongue and throat or body, fainting or difficulty in swallowing) signs of severe allergic skin reactions (such as skin redness with severe blisters or peeling, bleeding in the eyes, lips, mouth, nose or genitals associated with a high fever and joint pains) signs of liver problems (such as yellowing of the skin, dark urine and tiredness)
Warnings & Precautions
& PRECAUTIONSPREGNANCYESIUM L CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking ESIUM L CAPSULE. BREASTFEEDINGESIUM L CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking ESIUM L CAPSULE. DRIVING AND USING MACHINESDo not drive or operate any heavy tools or machines if you experience dizziness, drowsiness or blurred vision after taking ESIUM L CAPSULE. ALCOHOLAvoid consumption of alcohol while taking ESIUM L CAPSULE, as it could aggravate your existing disease condition. KIDNEYESIUM L CAPSULE is not recommended for use in patients with severe kidney disease. Consult your doctor before taking ESIUM L CAPSULE. LIVERESIUM L CAPSULE is not recommended for use in patients with severe liver disease. Consult your doctor before taking ESIUM L CAPSULE. ALLERGYDo not take ESIUM L CAPSULE if you are allergic to Levosulpiride, Esomeprazole or other proton pump inhibitors (Ex. pantoprazole, rabeprazole, omeprazole). HEART DISEASEESIUM L CAPSULE should be used with caution in patients with prolongation of QTc interval (irregular electrical activity of the heart), stroke and cardiac insufficiency. Consult your doctor before taking ESIUM L CAPSULE. OTHERSESIUM L CAPSULE is not recommended for use if you: have parkinson’s disease have history of epilepsy have porphyria (a rare blood disorder) have breast cancer or non-cancerous tumor in breast have alcohol intoxication (drinking too much alcohol in short period) have certain tumors like phaeochromocytoma (tumor in adrenal glands) or pituitary prolactinoma (tumors of pituitary gland) have hypokalemia (low blood potassium levels) have bleeding or perforation in the stomach or intestines have manic states (abnormally elevated mood) Before taking ESIUM L CAPSULE, inform your physician if you: are due to have a specific blood test (Chromogranin A) reduced vitamin B12 levels in body osteoporosis Use in pediatrics: ESIUM L CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness. Consult your child’s doctor for advice. Use in geriatrics: ESIUM L CAPSULE should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking ESIUM L CAPSULE.
Drug Interactions
SA. Drug-Drug interactions: Before taking ESIUM L CAPSULE inform to your doctor, if you are taking any of these medicines: medicines used to manage HIV infection (Ex. nelfinavir, atazanavir) medicines used to manage fungal infections (Ex. ketoconazole, itraconazole or voriconazole) medicines used to manage depression (Ex. citalopram, imipramine, clomipramine, rasagiline, selegiline, phenelzine, or St. John’s wort) anticholinergics (used to reduce gastrointestinal movements) such as atropine, biperiden or hyoscine butylbromide narcotic analgesics (used to provide pain relief) Ex. morphine, pethidine, fentanyl medicines that can make you feel sleepy or drowsy such as sedatives or hypnotics (Ex. phenobarbital) or tranquilizers (Ex. diazepam, clonazepam, lorazepam) clopidogrel (an antiplatelet medicine used to manage blood clots) erlotinib (used to manage cancer) phenytoin (used to manage epilepsy) medicines used for blood thinning (Ex. warfarin) cilostazol (a medicine used to manage intermittent claudication (pain in legs)) cisapride (used to manage heartburn or indigestion) digoxin (used to manage abnormal heart rhythm) methotrexate (a medicine used to manage cancer or other auto-immune disease) tacrolimus (used to suppress immune function and manage graft rejection) rifampicin (used to manage tuberculosis) diuretics (used to reduce blood pressure by increasing urine output) Ex. furosemide, hydrochlorothiazide B. Drug-Food interaction: ESIUM L CAPSULE can be taken with food or on an empty stomach. Try to take this medicine at least one hour before meals to maximize the efficacy. However, consult your doctor before taking ESIUM L CAPSULE. Overdosage: If you or anyone else accidentally take too much of ESIUM L CAPSULE, contact your doctor immediately or go to a hospital straight away. SYNOPSIS Drug : Esomeprazole, Levosulpiride Pharmacological Category : Proton pump inhibitors, Dopamine D2 antagonists Therapeutic Indication : Gastro-esophageal reflux disease (GERD), Peptic ulcer Dosage Forms : Tablet, Capsule MORE INFORMATION Keep ESIUM L CAPSULE out of reach of children Store at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
03 Nov 2022