Encorate 100mg Injection 5ml
Key Information
Generic Name
Generic Name Sodium Valproate 100 mg Also Known As: Valproic Acid
Manufacturer
Sun Pharmaceutical Industries Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT ENCORATE 100MG INJECTIONENCORATE 100MG INJECTION contains Sodium valproate, which belongs to the group of medicines called Anti-convulsant. It is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Symptoms include temporary confusion, staring spells, stiff muscles, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, fear, anxiety or déjà vu. ENCORATE 100MG INJECTION is not recommended for use if you have porphyria (affecting metabolism), liver problems or Alpers-Huttenlocher syndrome. Before receiving ENCORATE 100MG INJECTION inform your doctor if you have kidney, brain problems, carnitine palmitoyl transferase type II deficiency, diabetes, systemic lupus erythematosus, urea cycle disorder, a genetic problem caused by a mitochondrial disorder in your family. Do not consume alcohol while receiving ENCORATE 100MG INJECTION. ENCORATE 100MG INJECTION is not recommended or used in pregnant women, inform your doctor if you are breastfeeding. ENCORATE 100MG INJECTION should be used with caution in children and the elderly. The most common
Uses
OF ENCORATE 100MG INJECTION Manage epilepsy (fits)
How It Works
ENCORATE 100MG INJECTION increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
Directions for Use
ENCORATE 100MG INJECTION will be given to you only by a doctor or a nurse as a slow infusion into the veins (intravenously). Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects
receiving ENCORATE 100MG INJECTION are stomach pain, diarrhea, headache, feeling tired and weight gain. Consult your doctor if any of your symptoms become worse while taking ENCORATE 100MG INJECTION. USES OF ENCORATE 100MG INJECTION Manage epilepsy (fits) HOW ENCORATE 100MG INJECTION WORKSENCORATE 100MG INJECTION increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA. DIRECTIONS FOR USEENCORATE 100MG INJECTION will be given to you only by a doctor or a nurse as a slow infusion into the veins (intravenously). Your doctor will decide the right dose and duration depending on your age, body weight and disease condition. SIDE EFFECTS OF ENCORATE 100MG INJECTIONCOMMON stomach pain, feeling or being sick diarrhea dry or sore mouth or swollen gums shakes (tremors) in a part of your body or unusual eye movements feeling tired or sleepy headache weight gain thinning hair or changes to the color or texture of your hair irregular or delayed periods pain at the injection site RAREStop receiving ENCORATE 100MG INJECTION and contact your doctor immediately if you experience any of the following side effects: thoughts of harming or killing yourself an allergic reaction (rash, joint pain, fever (systemic lupus erythematosus), swallowing or breathing problems, swelling of your lips, face, throat or tongue, lymph node enlargement and possible impairment of other organs liver problems and problems of the pancreas may show as a sudden illness (feeling and being sick many times; being very tired, sleepy and weak, stomach pain, jaundice, loss of appetite, swelling of legs, worsening of fits skin rash or skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid (on the palms or soles of your feet, can be erythema multiforme) blistering or bleeding of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome) severe blistering rash where layers of the skin may peel off to leave large areas of raw exposed skin over the body, unwell, fever, chills and aching muscles (toxic epidermal necrolysis) bruising more easily and getting more infections than usual (thrombocytopenia), blood clotting problems changes in mood, loss of memory, lack of concentration and coma hypothyroidism, which may cause tiredness or weight gain breathing difficulty and pain due to inflammation of the lungs changes in behavior including being very alert and sometimes also aggressive, hyperactive and unusual or inappropriate behavior changes in the amount of ammonia in the blood (being sick, problems with balance and co-ordination, feeling lethargic or less alert) feeling shaky (tremor), sleepy or unsteady when walking or jerky muscle movements. rapid, uncontrollable movement of the eyes increase in the number and severity of convulsions liver damage, inflammation of the pancreas, bedwetting, renal dysfunction, overgrowth of gum tissue, aggression, agitation, disturbance in attention, abnormal behavior, hyperactivity and learning disorder in children kidney disease or kidney problems (renal failure, tubulointerstitial nephritis and Fanconi syndrome) which may manifest as reduced urinary output or blood in the urine confusion, which could be due to decreased levels of sodium in your blood (Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion)
Warnings & Precautions
& PRECAUTIONSPREGNANCYENCORATE 100MG INJECTION is not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. if you are a woman able to have a baby, you must not take it unless you use an effective method of birth control (contraception) during your entire> management. Do not stop taking this medicine or contraception, until you have discussed this with your doctor. Consult your doctor before receiving ENCORATE 100MG INJECTION. BREASTFEEDINGInform your doctor if you are breastfeeding before receiving ENCORATE 100MG INJECTION as very little medicine might pass through the breastmilk. Consult your doctor if you can breastfeed or not receive the medicine during the> management. DRIVING AND USING MACHINESDo not drive or use machines while receiving ENCORATE 100MG INJECTION as it can make you sleepy. ALCOHOLDo not consume alcohol while receiving ENCORATE 100MG INJECTION as it can worsen the side effects. KIDNEYENCORATE 100MG INJECTION should be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before receiving ENCORATE 100MG INJECTION. LIVERENCORATE 100MG INJECTION is not recommended for patients with liver problems or with a family history of liver disease. Consult your doctor before receiving ENCORATE 100MG INJECTION. ALLERGYDo not receive ENCORATE 100MG INJECTION if you are allergic to Sodium valproate or any other ingredients of this medicine. OTHERSENCORATE 100MG INJECTION is not recommended for use if you: have a rare illness called porphyria which affects metabolism have a known metabolic disorder, i.e., a urea cycle disorder have a genetic problem caused by a mitochondrial disorder (Alpers-Huttenlocher syndrome) are a woman of birth-giving age and not using contraceptives (birth control) Before receiving ENCORATE 100MG INJECTION, inform your doctor if you: have diabetes have a carnitine palmitoyl transferase type II deficiency have a brain disease or a metabolic condition affecting the brain have a ‘urea cycle disorder’ where too much ammonia builds up in the body. have an illness called systemic lupus erythematosus (SLE) (an immune system which affects skin, bones, joints and internal organs) genetic problem caused by a mitochondrial disorder in your family Use in pediatrics: ENCORATE 100MG INJECTION should be used with caution in children only if recommended by your doctor. Consult your doctor for advice. Use in geriatrics: ENCORATE 100MG INJECTION should be used with caution in the elderly only if recommended by your doctor. Consult your doctor for advice.
Drug Interactions
SA. Drug-Drug interactions: Before receiving ENCORATE 100MG INJECTION, inform your doctor if you are taking any of the following medicine: medicines used for pain and inflammation (salicylates) (Ex. aspirin) other medicines used to manage fits (Ex. phenobarbital, primidone, phenytoin, carbamazepine, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate) medicines used for thinning the blood (Ex. warfarin). zidovudine, lopinavir and ritonavir (to manage HIV infection) temozolomide (to manage cancer) medicines for depression (monoamine oxidase inhibitors (MAOI) such as moclobemide, selegiline, linezolid) selegiline (used to manage Parkinson’s disease), linezolid (used to manage infections). medicines used to calm emotional and mental health problems (Ex. quetiapine, diazepam and olanzapine) nimodipine (to manage hemorrhage) propofol (used for anesthesia) oestrogen-containing products (including some birth control pills). medicines to manage malaria (Ex. mefloquine and chloroquine) cimetidine (for stomach ulcers) carbapenem agents (antibiotics used to manage bacterial infections) Ex. imipenem, meropenem, rifampicin and erythromycin cholestyramine is used to lower blood fat (cholesterol) levels. metamizole (to manage pain and fever) Overdosage: ENCORATE 100MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like feeling sick or being sick, pupils of the eye become smaller, dizziness, loss of consciousness, weak muscles and poor reflexes, breathing problems, headaches, fits (seizures), confusion, memory loss and unusual or inappropriate behavior. SYNOPSIS Drug : Sodium Valproate Pharmacological Category : Anti-convulsant Therapeutic Indication : Epilsepsy (fits) Dosage Forms : Tablet, Injection, Syrup, Oral solution MORE INFORMATION Keep ENCORATE 100MG INJECTION out of reach from children Store at room temperature
Article Information
Written By
DETAILS Written By Dr. Dhivakaran R
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
28 Oct 2022