DM LEF 20 Tablet 10's
Key Information
Generic Name
Generic Name Leflunomide 20 mg
Manufacturer
Overseas Healthcare Pvt Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
DM LEF 20 TABLET contains Leflunomide which belongs to the group of medicines called Anti-rheumatics. It is indicated in adults for the management of active rheumatoid arthritis. Rheumatoid arthritis is an auto-immune chronic inflammatory disorder which affects many joints including those in the hands and feet. Symptoms include inflammation of joints, swelling, difficulty moving and pain, loss of appetite, fever, loss of energy and anaemia (lack of red blood cells). DM LEF 20 TABLET is also used in adults to manage active psoriatic arthritis. Active psoriatic arthritis refers to a condition where psoriasis, a skin condition is present along with arthritis. Symptoms include inflammation of joints, swelling, difficulty in moving, pain and patches of red and scaly skin (skin lesions). Before starting management with DM LEF 20 TABLET, your doctor might ask you to take a few blood tests to understand the existing condition and to use this medicine safely. DM LEF 20 TABLET is not recommended for use in patients having liver or moderate to severe kidney disease, any problem which affects the immune system (like AIDS), bone marrow problems, serious infections, severely low levels of proteins in the blood (hypoproteinaemia) and reduced levels of white or red blood cells and platelet count. DM LEF 20 TABLET should be used with caution in patients who have interstitial lung disease, tuberculosis and if you are a male who wishes to father a child and chronic diarrhoea. Avoid consumption of alcohol during management with this medicine as it may increase the risk of liver damage. DM LEF 20 TABLET is not recommended for use in pregnant women or women who become pregnant during management with this medicine and it is not recommended for use in breastfeeding women. DM LEF 20 TABLET is not recommended for use in children and adolescents (below 18 years of age). The most common
Uses
OF DM LEF 20 TABLETManages, active rheumatoid arthritis active psoriatic arthritis
How It Works
DM LEF 20 TABLET acts by inhibiting an enzyme which results in stopping the activated and autoimmune white blood cells. This inhibition leads to anti-inflammatory and immunomodulatory effects, reducing inflammation due to arthritis.
Directions for Use
Take DM LEF 20 TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
taking DM LEF 20 TABLET are loss of appetite, tiredness, headache, dizziness, diarrhoea, nausea, vomiting, inflammation of the mouth or mouth ulcers, abdominal pain and increased hair loss. Consult your doctor if any of the side effects worsen. USES OF DM LEF 20 TABLETManages, active rheumatoid arthritis active psoriatic arthritis HOW DM LEF 20 TABLET WORKSDM LEF 20 TABLET acts by inhibiting an enzyme which results in stopping the activated and autoimmune white blood cells. This inhibition leads to anti-inflammatory and immunomodulatory effects, reducing inflammation due to arthritis. DIRECTIONS FOR USETake DM LEF 20 TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF DM LEF 20 TABLETCOMMON mild allergic reactions loss of appetite, weight loss tiredness headache, dizziness abnormal skin sensations like tingling (paraesthesia) mild increase in blood pressure diarrhoea, inflammation of the colon nausea, vomiting mouth ulcers or swelling of the mouth abdominal pain increased hair loss eczema, dry skin, rash, itching tendonitis (pain in feet or hands caused by inflammation in the membrane surrounding the tendons) problems affecting the nerves of the arms or legs UNCOMMON anxiety taste disturbances urticaria (nettle rash) tendon rupture RARE severe increase in blood pressure inflammation of the lung (interstitial lung disease) hepatitis and jaundice (yellowing of the skin or white of the eyes) sepsis (severe infection) Stop taking DM LEF 20 TABLET and contact your doctor immediately if you experience any of the following side effects: serious allergic reaction (signs include weakness, light-headedness or dizziness or have difficulty breathing) skin rash and ulcers in the mouth (Drug Reaction with Eosinophilia and Systematic Symptoms (DRESS), stevens-johnson syndrome and toxic epidermal necrolysis) blood disorders (signs include pale skin, tiredness, bruising) signs of liver failure (signs include tiredness, abdominal pain and jaundice) signs of infection (signs include cough, fever and sore throat) coughing or breathing problems (signs include interstitial lung disease or pulmonary hypertension) signs of peripheral neuropathy (unusual tingling, weakness or pain in the hands or feet)
Warnings & Precautions
& PRECAUTIONSPREGNANCYDM LEF 20 TABLET is not recommended for use in pregnant women or women who become pregnant during management with this medicine, as it may increase the risk of serious birth defects in the baby. Women of childbearing potential should not take DM LEF 20 TABLET without using reliable contraceptive measures. If you plan to become pregnant after stopping management with this medicine and it is necessary to ensure that all traces of the medicine have left your body, this may take up to 2 years. Consult your doctor before taking DM LEF 20 TABLET. BREASTFEEDINGDM LEF 20 TABLET is not recommended for use in breastfeeding women as it passes through the breast milk. Consult your doctor before taking DM LEF 20 TABLET. DRIVING AND USING MACHINESDo not drive or operate any machines if you feel dizzy after taking DM LEF 20 TABLET. ALCOHOLAvoid consumption of alcohol while taking DM LEF 20 TABLET as it may increase the chances of liver damage. KIDNEYDM LEF 20 TABLET is not recommended for use in patients with moderate to severe kidney problems. Consult your doctor before taking DM LEF 20 TABLET. LIVERDM LEF 20 TABLET is not recommended for use in patients with any liver problems. Consult your doctor before taking DM LEF 20 TABLET. ALLERGYDo not take DM LEF 20 TABLET if you are allergic to Leflunomide or any other ingredients of this medicine. LUNGSDM LEF 20 TABLET should be used with caution in patients who have suffered with interstitial lung disease or if you ever had tuberculosis. Consult your doctor before taking DM LEF 20 TABLET. OTHERSGBNKEYWORD] is not recommended for use if you: have any problem which affects the immune system (like AIDS) have bone marrow problems or reduced white blood or red blood cells and platelets have serious infections have hypoproteinaemia (severely low levels of proteins in the blood) Before taking DM LEF 20 TABLET, inform your doctor if you: are a male who wishes to father a child are due to have a specific blood test (calcium test) unexplained chronic diarrhoea Use in paediatrics: DM LEF 20 TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.
Drug Interactions
SA. Drug – Drug Interactions: Before taking DM LEF 20 TABLET, inform your doctor if you are taking any of the following medicines: other medicines for rheumatoid arthritis (Ex. sulfasalazine), antimalarials (Ex. chloroquine and hydroxychloroquine), intramuscular or oral gold, D-penicillamine medicines used as immunosuppressants (Ex. azathioprine, methotrexate) medicines used as blood thinners (Ex. warfarin) medicines used to manage multiple sclerosis (Ex. teriflunomide) medicines used for the management of diabetes (repaglinide, pioglitazone, nateglinide, rosiglitazone) medicines used in the management of cancer (daunorubicin, doxorubicin, paclitaxel, topotecan) medicine used for depression, urinary incontinence or in kidney disease in diabetics (Ex. duloxetine) medicines used for the management of severe diarrhoea (Ex alosetron) medicines used to manage asthma (Ex. theophylline) medicines used as a muscle relaxant (Ex. tizanidine) oral contraceptives (Ex. ethinylestradiol, levonorgestrel) medicines used for infections (Ex. cefaclor, benzylpenicillin (penicillin G), ciprofloxacin) medicines used for the management of pain or inflammation (Ex. indomethacin, ketoprofen) diuretics for heart disease (Ex. furosemide) medicines used in the management of HIV infection (Ex. zidovudine) medicines used in the management of high cholesterol (Ex. rosuvastatin, simvastatin, atorvastatin, colestyramine, pravastatin) activated charcoal (used to manage certain kinds of poisoning) vaccinations Overdosage: If you or anyone else accidentally takes too much of DM LEF 20 TABLET, consult your doctor immediately or visit the nearby hospital. SYNOPSIS Drug : Leflunomide Pharmacological Category : Disease-Modifying Antirheumatic Drug (DMARD) Therapeutic Indication : Rheumatoid Arthritis, Active psoriatic arthritis Dosage Forms : Tablet MORE INFORMATION Keep DM LEF 20 TABLET out of reach of children Store the medicine at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
27 Sep 2022