DAPAFLOZIN GM 2/1000 Tablet 10's
Key Information
Generic Name
Generic Name Dapagliflozin 10 mg+Glimepiride 2 mg+Metformin 1000 mg
Manufacturer
PREVEGO HEALTHCARE & RESEARCH PRIVATE LIMITED (Generics)
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
DAPAFLOZIN GM 2/1000 TABLET is a combination of Dapagliflozin, Glimepiride, and Metformin, which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response. Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin. Before taking DAPAFLOZIN GM 2/1000 TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished or starved on an irregular diet as a precaution. DAPAFLOZIN GM 2/1000 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis, severe low blood pressure, or severe dehydration. It is also not suitable for use in pregnant or breastfeeding women. Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking DAPAFLOZIN GM 2/1000 TABLET, as it may aggravate your existing condition. During therapy with DAPAFLOZIN GM 2/1000 TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted
Uses
OF DAPAFLOZIN GM 2/1000 TABLET It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus.
How It Works
DAPAFLOZIN GM 2/1000 TABLET contains three medicines, namely, metformin, glimepiride, and dapagliflozin. Metformin and glimepiride stimulate the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also make our body more sensitive to insulin, which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, metformin can also reduce the glucose produced by the liver and reduce its absorption in the body. Dapagliflozin is an SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose from the body in the form urine.
Directions for Use
Take DAPAFLOZIN GM 2/1000 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition. Do not stop taking DAPAFLOZIN GM 2/1000 TABLET unless your doctor advises you to stop.
Side Effects
taking DAPAFLOZIN GM 2/1000 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen. USES OF DAPAFLOZIN GM 2/1000 TABLET It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus. HOW DAPAFLOZIN GM 2/1000 TABLET WORKSDAPAFLOZIN GM 2/1000 TABLET contains three medicines, namely, metformin, glimepiride, and dapagliflozin. Metformin and glimepiride stimulate the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also make our body more sensitive to insulin, which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, metformin can also reduce the glucose produced by the liver and reduce its absorption in the body. Dapagliflozin is an SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose from the body in the form urine. DIRECTIONS FOR USETake DAPAFLOZIN GM 2/1000 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition. Do not stop taking DAPAFLOZIN GM 2/1000 TABLET unless your doctor advises you to stop. SIDE EFFECTS OF DAPAFLOZIN GM 2/1000 TABLETCOMMON hypoglycemia (low blood sugar levels) nausea, vomiting diarrhea, stomach pain, loss of appetite, flatulence changes in taste, metallic taste headache, dizziness joint pain, back pain, muscle pain impotence sinus infection, sore throat fungal infections of the genital (thrush) causing itching, irritation, unusual discharge, odour passing more urine, increased urine frequency skin rash changes in blood cholesterol levels changes in RBC in blood UNCOMMON difficulty in sleeping (insomnia) proteins in urine spinning sensation (vertigo) dehydration, thirst, constipation, dry mouth weight loss RAREStop taking DAPAFLOZIN GM 2/1000 TABLET and contact your doctor immediately if you experience any of the following side effects: signs of diabetic ketoacidosis or lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat, and rapid weight loss) symptoms of heart failure (such as unusual shortness of breath or trouble breathing, rapid increase in weight or localized swelling (oedema), especially in the ankles or legs, unusual tiredness) blurred vision, urinary tract infections pain, swelling, redness, or tenderness of the genitals or the areas between the genitals and the anus accompanied by a high fever or a feeling generally unwell (a sign of necrotizing fasciitis of the perineum)
Warnings & Precautions
& PRECAUTIONSPREGNANCYContraindicatedDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. BREASTFEEDINGContraindicatedDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it. DRIVING AND USING MACHINESUse with CautionDo not drive or operate any heavy tools or machines if your ability is affected by DAPAFLOZIN GM 2/1000 TABLET. ALCOHOLConsult your doctorAvoid consumption of alcohol while taking DAPAFLOZIN GM 2/1000 TABLET, as it may increase the risk of unwanted side effects. KIDNEYConsult your doctorDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with mild to moderate kidney problems. Therefore, consult your doctor before taking it. LIVERConsult your doctorDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it. ALLERGYContraindicatedDo not take DAPAFLOZIN GM 2/1000 TABLET if you are allergic to Glimepiride, Metformin, or Dapagliflozin. HEART DISEASEConsult your doctorDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it. USE IN PEDIATRICSContraindicatedDAPAFLOZIN GM 2/1000 TABLET is not recommended for use in children and in adolescents (aged below 18 years). Therefore, consult your doctor before taking it. USE IN GERIATRICSUse with CautionDAPAFLOZIN GM 2/1000 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it. OTHERSDAPAFLOZIN GM 2/1000 TABLET is not recommended for use if you: have type I diabetes mellitus (insulin-dependent diabetes) have lactic acidosis (buildup of lactic acid in the body) have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination, and muscular stiffness) have bladder cancer pass bloody urine Before taking DAPAFLOZIN GM 2/1000 TABLET, inform your doctor if you: are recovering from any injury, operation, infection, or from any form of stress have G6PD deficiency are on fating or malnourished, starved, on an irregular diet, or feeling weak perform extreme physical exercises without proper carbohydrate intake are severely dehydrated have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex, or thyroid gland) are an alcoholic have edema (swelling of body parts) have a habit of smoking have cysts on your ovaries (polycystic ovarian syndrome) previously had stroke have anemia (low RBC in blood) have diabetes-related kidney problems
Drug Interactions
SBefore taking DAPAFLOZIN GM 2/1000 TABLET, inform your doctor if you are taking any of the following medicines: Other medicines used to regulate blood sugar levels (such as teneligliptin, rosiglitazone, insulin, and gliclazide) Medicines used in pain management (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone, prednisolone, betamethasone) Medicines for managing urinary infections (amikacin, nitrofurantoin, sulfamethoxazole) Antibiotics (such as tetracyclines, chloramphenicol, ciprofloxacin, and clarithromycin); antifungals (fluconazole, miconazole, and isuvaconazole) medicines used for blood thinning (Ex. warfarin) Hormones (Ex. testosterone, estradiol) Medicines used in the management of mental illnesses (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, and lithium) Antihyperlipidemics (Ex. fenofibrate, nicotinic acid, colesevelam) Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, reserpine, prazosin, doxazosin) medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone) medicines used in the management of cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib) medicines used in the management of allergic rhinitis (Ex. tritoqualine) Water pills (Ex. hydrochlorothiazide) Anti-asthmatics (Ex. salbutamol, terbutaline) adrenaline (a medicine used for anaphylaxis) Medicines used for constipation (Ex. lactulose, liquid paraffin) Overdosage: If you or anyone else accidentally took more DAPAFLOZIN GM 2/1000 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat, and confusion). To manage this, consume any sugary food immediately. If the symptoms do not improve or worsen, contact your doctor immediately. Other symptoms of overdose might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness, and difficulty breathing. SYNOPSIS Drug : Dapagliflozin, Glimepiride, Metformin Pharmacological Category : SGLT-2 Inhibitors, Sulfonylureas, and Biguanides Therapeutic Indication : Improve glycemic control Dosage Forms : Tablet MORE INFORMATIONSTORAGE Keep DAPAFLOZIN GM 2/1000 TABLET out of reach of children Store DAPAFLOZIN GM 2/1000 TABLET at room temperature
Frequently Asked Questions
Common questions and answers about DAPAFLOZIN GM 2/1000 Tablet 10's.
What is DAPAFLOZIN GM 2/1000 TABLET used for?
DAPAFLOZIN GM 2/1000 TABLET is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response.
How and when to take DAPAFLOZIN GM 2/1000 TABLET?
Take DAPAFLOZIN GM 2/1000 TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
How long should I take DAPAFLOZIN GM 2/1000 TABLET?
You need to take DAPAFLOZIN GM 2/1000 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
What is the best time to take DAPAFLOZIN GM 2/1000 TABLET?
DAPAFLOZIN GM 2/1000 TABLET must be taken with meals to avoid gastrointestinal side effects.
What to do if I forgot to take a dose of DAPAFLOZIN GM 2/1000 TABLET?
If you forgot to take a dose of DAPAFLOZIN GM 2/1000 TABLET, take it as soon as you remember. However, if it is time for the next dose of DAPAFLOZIN GM 2/1000 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of DAPAFLOZIN GM 2/1000 TABLET to compensate for the missed ones.
Can I stop taking DAPAFLOZIN GM 2/1000 TABLET without consulting your doctor?
No. You should not stop taking DAPAFLOZIN GM 2/1000 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using DAPAFLOZIN GM 2/1000 TABLET, consult your doctor for advice.
Will taking a higher dose of DAPAFLOZIN GM 2/1000 TABLET be more effective?
No, taking a higher dose of DAPAFLOZIN GM 2/1000 TABLET will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I take medication for high blood pressure along with DAPAFLOZIN GM 2/1000 TABLET?
It is not advisable to take medicines to control blood pressure while taking DAPAFLOZIN GM 2/1000 TABLET without consulting your doctor, as they have known interactions with DAPAFLOZIN GM 2/1000 TABLET.
How to manage the side effects of DAPAFLOZIN GM 2/1000 TABLET?
Low blood sugar is a common side effect of taking DAPAFLOZIN GM 2/1000 TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not at the optimum level, take another sugary snack or drink and check the blood sugar levels once again. If your condition does not improve, consult your doctor immediately.
Can DAPAFLOZIN GM 2/1000 TABLET be taken with insulin?
Co-administration of DAPAFLOZIN GM 2/1000 TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Can DAPAFLOZIN GM 2/1000 TABLET be used in pregnant women?
DAPAFLOZIN GM 2/1000 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
What are the side effects of taking DAPAFLOZIN GM 2/1000 TABLET?
The most common side effects of taking DAPAFLOZIN GM 2/1000 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen.
Can DAPAFLOZIN GM 2/1000 TABLET cause urinary tract infection?
Yes, taking DAPAFLOZIN GM 2/1000 TABLET may cause urinary tract infections in few people. Not every individual gets the side effect, so it is always better to practice good hygiene. Contact your doctor for advice.
Can DAPAFLOZIN GM 2/1000 TABLET cause constipation?
Yes. Constipation is a common side effect of using DAPAFLOZIN GM 2/1000 TABLET. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.
Article Information
Written By
DETAILS Written By Dr. N. Sai Swaroop
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
11 Sep 2024