CTD O 12.5/40mg Tablet 10'S
Key Information
Generic Name
Generic Name Chlorthalidone 12.50 mg+Olmesartan 40 mg
Manufacturer
Ipca Laboratories Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
CTD O 12.5/40MG TABLET is a combination of Chlorthalidone and Olmesartan which belongs to the group of medicines called Thiazide diuretics and Angiotensin-II receptor antagonists respectively. CTD O 12.5/40MG TABLET is indicated for the management of essential hypertension. Essential hypertension (also known as primary hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result, it may lead to severe damage to the walls of blood vessels supplying various important organs. It occurs without any known secondary cause and if it remains unmanageed it can lead to severe problems such as heart attack, heart or kidney failure, stroke or even blindness. Along management with CTD O 12.5/40MG TABLET follow lifestyle modifications (such as losing weight, quitting smoking or alcohol intake) as advised by your physician along with a healthy balanced diet and regular physical activity (such as walking or swimming). During the course of the management with CTD O 12.5/40MG TABLET, your doctor might regularly check your blood pressure, kidney function and electrolyte balance to avoid the risk of
Uses
OF CTD O 12.5/40MG TABLET Manage essential hypertension
How It Works
CTD O 12.5/40MG TABLET effectively reduces elevated blood pressure where olmesartan acts by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increases in blood pressure) at the angiotensin type-I receptors of the vascular smooth muscle and chlorthalidone acts by increasing the urinary excretion of sodium and water by inhibiting sodium-chloride reabsorption in the kidneys, thus leading to a marked decrease in blood pressure.
Directions for Use
Take CTD O 12.5/40MG TABLET as advised by your physician. Swallow CTD O 12.5/40MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
this medicine. Before taking CTD O 12.5/40MG TABLET, inform your doctor if you have diabetes, liver, kidney or heart disease as a precaution. CTD O 12.5/40MG TABLET is strictly not recommended for use in pregnant or breastfeeding women as it could cause serious harm to the baby. CTD O 12.5/40MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. It should be used with extreme caution in elderly patients (aged 65 years or above). The most common side effects of taking CTD O 12.5/40MG TABLET are headache, dizziness, tiredness, nausea, stomach pain, lack of appetite and indigestion. Consult your doctor if any of the side effects worsen. USES OF CTD O 12.5/40MG TABLET Manage essential hypertension HOW CTD O 12.5/40MG TABLET WORKSCTD O 12.5/40MG TABLET effectively reduces elevated blood pressure where olmesartan acts by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increases in blood pressure) at the angiotensin type-I receptors of the vascular smooth muscle and chlorthalidone acts by increasing the urinary excretion of sodium and water by inhibiting sodium-chloride reabsorption in the kidneys, thus leading to a marked decrease in blood pressure. DIRECTIONS FOR USETake CTD O 12.5/40MG TABLET as advised by your physician. Swallow CTD O 12.5/40MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF CTD O 12.5/40MG TABLETCOMMON headache and dizziness nausea, indigestion, diarrhoea, stomach pain tiredness sore throat, runny nose, flu-like symptoms, cough chest pain, back pain, joint pain urinary tract infection swelling of the feet, ankles, hands or arms blood in urine skin rash orthostatic hypertension (feeling dizzy while standing up) loss of appetite impotence in men UNCOMMON mood changes, anxiety, depression sleeplessness dry mouth vomiting hair loss increased sweating red patches, itchy skin skin discolouration increased or decrease weight pain, general discomfort enlarged breasts in men (gynecomastia) increased urination, urinary urgency (at night) disorder in passing urine RARE muscle cramps kidney problems worsening of diabetes jaundice (yellowing of the skin or eyes) photosensitivity breathing problems, palpitations and fainting tingling or prickling sensation (usually in arms, hands, legs or feet) constipation Stop taking CTD O 12.5/40MG TABLET and contact your doctor immediately if you experience any of the following side effects: severe allergic reactions (such as skin rash, itching, swelling of the face, mouth and/or larynx) severe hypotension (low blood pressure) with light-headedness or fainting
Warnings & Precautions
& PRECAUTIONSPREGNANCYCTD O 12.5/40MG TABLET is not recommended for use in pregnant women because it can cause serious harm to the developing fetus. Consult your doctor before taking CTD O 12.5/40MG TABLET. BREASTFEEDINGCTD O 12.5/40MG TABLET is not recommended for use in breastfeeding women because it passes through the breast milk and could cause serious harm to the baby. Consult your doctor before taking CTD O 12.5/40MG TABLET. DRIVING AND USING MACHINESDo not drive or operate any heavy tools or machines if you experience dizziness, sleepiness or tiredness. Consult your doctor before taking CTD O 12.5/40MG TABLET. ALCOHOLAvoid consumption of alcohol while taking CTD O 12.5/40MG TABLET, as it could aggravate your existing disease condition. Consult your doctor before taking CTD O 12.5/40MG TABLET. KIDNEYCTD O 12.5/40MG TABLET is not recommended for use in patients with severe kidney problems, kidney failure, lack of urine, and kidney stones and should be used with caution in patients with kidney problems. Consult your doctor before taking CTD O 12.5/40MG TABLET. LIVERCTD O 12.5/40MG TABLET is not recommended for use in patients with severe liver disease, jaundice (yellowing of skin and eyes) or biliary obstruction (a problem in bile drainage) and should be used with caution in patients with liver disease. Consult your doctor before taking CTD O 12.5/40MG TABLET. ALLERGYDo not take CTD O 12.5/40MG TABLET if you are allergic to Chlorthalidone, Olmesartan or any sulphonamide derivatives (Ex. sulfadiazine, sulfamethazine). HEART DISEASECTD O 12.5/40MG TABLET is not recommended for use in patients with heart failure or attack, cardiogenic shock, narrowing of the aortic heart valve and severe low blood pressure. It should be used with caution in patients with coronary or cerebral arteriosclerosis and obstructive hypertrophic cardiomyopathy (heart muscle becomes abnormally thick). Consult your doctor before taking CTD O 12.5/40MG TABLET. OTHERSCTD O 12.5/40MG TABLET is not recommended for use if you have: severe fluid-electrolyte imbalance (such as low levels of potassium, sodium or calcium in the blood) a history of gout unmanageed addison's disease (an endocrine disorder of adrenal glands) primary aldosteronism (a disorder due to increased aldosterone production) diabetes or diabetes-related kidney problems (Ex. diabetic nephropathy) Before taking CTD O 12.5/40MG TABLET, inform your physician if you: have high blood cholesterol levels are on a low-sodium diet have severe vomiting or diarrhea have hyperkalemia (increased blood potassium levels) have metabolic acidosis (increase in plasma acidity) have a condition that involves cellular breakdown or damage (Ex. acute limb ischemia (decrease blood flow to lower limb), rhabdomyolysis (severe muscle injury), extended trauma) have hyperparathyroidism (overactive parathyroid gland) have recently had an anesthetic Use in pediatrics: CTD O 12.5/40MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. Consult your child’s doctor for advice. Use in geriatrics: CTD O 12.5/40MG TABLET should be used with extreme caution in elderly patients (aged 65 years or above). Proper dose adjustments and careful monitoring of blood pressure, kidney function and electrolyte balance are required in such patients. Consult your doctor before taking CTD O 12.5/40MG TABLET.
Drug Interactions
SA. Drug-Drug interactions: Before taking CTD O 12.5/40MG TABLET inform to your doctor, if you are taking any of these medicines: other medicines used to reduce high blood pressure and other heart problems such as angiotensin-converting enzyme (ACE) inhibitors (Ex. captopril, enalapril), angiotensin receptor blockers (Ex. losartan, valsartan), calcium channel blockers (Ex. nifedipine, diltiazem, verapamil), beta-blockers (Ex. atenolol, propranolol), vasodilators (Ex. nitroglycerin, bosentan), digoxin, methyldopa, guanethidine or aliskiren hypericum perforatum (herbal medicine), lithium (used to manage depression or other mental illness) non-steroidal anti-inflammatory drugs (used to manage pain or inflammation) Ex. indomethacin simvastatin, colesevelam and cholestyramine (used to control high blood cholesterol levels) antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, magnesium hydroxide ketoconazole, itraconazole or amphotericin (used to manage fungal infections) protease inhibitors (used to manage HIV infection) Ex. ritonavir, indinavir, nelfinavir certain antibiotics (used to manage bacterial infections) Ex. rifampicin, erythromycin, clarithromycin dantrolene (used to manage muscle spasticity) immunosuppressant (used to suppress immune function and manage graft rejection) Ex. tacrolimus, sirolimus, temsirolimus, everolimus or cyclosporine adrenocorticotropic hormone (used to manage various endocrine disorders) corticosteroids (used to manage allergic or inflammatory diseases and immune reactions) such as prednisolone or betamethasone anticholinergics (used to reduce stomach spasms or cramps) such as atropine, biperiden or hyoscine butylbromide cyclophosphamide or methotrexate (used to manage certain forms of cancer) salbutamol or formoterol (used to manage asthma) amantadine (a medicine used to manage viral infections or Parkinson’s disease) allopurinol (a medicine used to manage gout) carbenoxolone (a medicine used to manage stomach ulcers) calcium salts or vitamin D (used as a supplement) medicines used to manage diabetes (Ex. insulin, chlorpropamide or glibenclamide) diazoxide (used to manage low blood glucose levels) medicines that can alter blood potassium levels such as potassium-sparing diuretics (Ex. spironolactone, acetazolamide), salt substitutes containing potassium (Ex. losartan potassium) heparin (used to manage or manage blood clots) B. Drug-Food interaction: CTD O 12.5/40MG TABLET can be taken with or without food. Avoid consumption of grapefruit or grapefruit juice while taking CTD O 12.5/40MG TABLET as it may cause severe decrease in blood pressure. Overdosage: If you or anyone else accidentally take too much of CTD O 12.5/40MG TABLET, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of CTD O 12.5/40MG TABLET might include dizziness, excess sleepiness, nausea, hypovolemia, low blood pressure and electrolyte disturbances associated with cardiac arrhythmias and muscle spasms. SYNOPSIS Drug : Chlorthalidone, Olmesartan Pharmacological Category : Thiazide diuretics, Angiotensin-II receptor antagonists Therapeutic Indication : Essential hypertension Dosage Forms : Tablet MORE INFORMATION Keep CTD O 12.5/40MG TABLET out of reach of children Store CTD O 12.5/40MG TABLET at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
11 Nov 2022