Combimist L Respule 5X2.5ml
Key Information
Generic Name
Generic Name Ipratropium 500 mcg+Levosalbutamol 1.25 mg
Manufacturer
Zydus Healthcare Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT COMBIMIST L RESPULECOMBIMIST L RESPULE is a combination of Ipratropium and Levosalbutamol which belongs to the group of medicines called Bronchodilator agents and Adrenergic beta-agonists, respectively. COMBIMIST L RESPULE is used to manage bronchospasm (tightened airway muscles) associated with chronic obstructive pulmonary disease (inflammatory lung disease) in patients who require more than one bronchodilator (medication) to help them in easy of breathing. COMBIMIST L RESPULE is not recommended for use in patients allergic to ipratropium, levosalbutamol, and/or atropine. Before using COMBIMIST L RESPULE, inform your doctor if you have high blood pressure, seizures, diabetes, narrow angle glaucoma (increased eye pressure), lung problems (such as asthma), heart problems (such as coronary insufficiency, cardiac arrhythmias), kidney problems (such as renal impairment), and/or liver problems (such as hepatic impairment). COMBIMIST L RESPULE should be used with caution during pregnancy and in women planning for pregnancy. It is also used with caution in breastfeeding women only if necessary. COMBIMIST L RESPULE is not recommended for use in children (aged less than 6 years). It should be used with caution in children and adolescents (aged 6 to 18 years). Consult your doctor before administering COMBIMIST L RESPULE. The most common
Uses
OF COMBIMIST L RESPULE Manage bronchospasm associated with chronic obstructive pulmonary disease (inflammatory lung disease) in affected individuals
How It Works
COMBIMIST L RESPULE provides ease in breathing from bronchospasm (constricted airway muscles), where Ipatropium and Levosalbutamol work together to relax airway muscles which results in widening of airways providing relief from obstructive airflow and easy in breathing from bronchospasm associated with chronic obstructive pulmonary disease in affected individuals.
Directions for Use
COMBIMIST L RESPULE should be administered only by a nebulizer (with a face mask connected to an air compressor) under the direction of a physician. It is for inhalation use only. Remove the pouch and tear one respule. Twist the cap to open the respule. Squeeze the content into the reservoir of nebulizing chamber and discard the respule after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects
using COMBIMIST L RESPULE are headache, dizziness, nervousness, cough, sore throat, local irritation, dry mouth, nausea, and/or diarrhoea. Consult your doctor if any of these symptoms worsens. USES OF COMBIMIST L RESPULE Manage bronchospasm associated with chronic obstructive pulmonary disease (inflammatory lung disease) in affected individuals HOW COMBIMIST L RESPULE WORKSCOMBIMIST L RESPULE provides ease in breathing from bronchospasm (constricted airway muscles), where Ipatropium and Levosalbutamol work together to relax airway muscles which results in widening of airways providing relief from obstructive airflow and easy in breathing from bronchospasm associated with chronic obstructive pulmonary disease in affected individuals. DIRECTIONS FOR USECOMBIMIST L RESPULE should be administered only by a nebulizer (with a face mask connected to an air compressor) under the direction of a physician. It is for inhalation use only. Remove the pouch and tear one respule. Twist the cap to open the respule. Squeeze the content into the reservoir of nebulizing chamber and discard the respule after use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF COMBIMIST L RESPULECOMMON headache, dizziness tremor, nervousness, pain cough, sore throat, local irritation dry mouth, upset stomach, nausea, constipation, diarrhoea, vomiting urinary tract infection leg cramps voice changes racing heartbeat, fast heart rate UNCOMMON red itchy welts accommodation disturbances, narrow angle-glaucoma (increased eye pressure) fast heart rate spasm of larynx diffuse skin rash RARE signs of anaphylactic reaction (life threatening allergic reaction) such as wheezing, faint, breathing difficulties, and/or fast heartbeat swelling of tongue/lips/face eye pain, dilate pupil irregular heartbeats urinary retention Stop using COMBIMIST L RESPULE and contact your doctor immediately if you experience any of the following side effects: signs of paradoxical bronchospasm (sudden constriction of airways after using medicine) such as shortness of breath, coughing, and/or wheezing signs of sudden hypersensitivity reaction (immune mediated allergic reaction) such as red itchy welts, swelling of face/mouth/tongue, bronchospasm (tighten airways), and/or rash signs of significant cardiovascular effects measured by pulse rate, blood pressure, and/or other symptoms
Warnings & Precautions
& PRECAUTIONSPREGNANCYCOMBIMIST L RESPULE should be used with caution during pregnancy and in women planning for pregnancy only if it is clearly necessary. Consult your doctor before using the medicine. BREASTFEEDINGCOMBIMIST L RESPULE should be used with caution in breastfeeding women only if necessary since it is not known whether the medicine pass through breast milk. Consult your doctor before using the medicine. DRIVING AND USING MACHINESDo not drive/operate machines if COMBIMIST L RESPULE affects your ability to drive/operate machines. KIDNEYCOMBIMIST L RESPULE should be used with caution in patients with kidney problems such are renal impairment. Consult your doctor before using the medicine. LIVERCOMBIMIST L RESPULE should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before using the medicine. ALLERGYDo not take COMBIMIST L RESPULE if you are allergic to ipratropium, levosalbutamol, atropine, and/or any other ingredients of the medicine. LUNGSCOMBIMIST L RESPULE should be used with caution in patients with lung problems such as asthma. Consult your doctor before using the medicine. HEART DISEASECOMBIMIST L RESPULE should be used with caution in patients with heart problems such as coronary insufficiency, cardiac arrhythmias. Consult your doctor before using COMBIMIST L RESPULE. OTHERSBefore using COMBIMIST L RESPULE inform your doctor if you: have high blood pressure have seizures suffer from hyperthyroidism (overactive thyroid) have diabetes have narrow angle glaucoma (increased eye pressure) suffer from prostatic hypertrophy (enlarged prostate gland) suffer from bladder-neck obstruction. Use in Paediatrics: COMBIMIST L RESPULE is not recommended for use in children (aged less than 6 years). It should be used with caution in children and adolescents (aged 6 to 18 years). Consult your doctor before administering COMBIMIST L RESPULE. Use in Geriatrics: COMBIMIST L RESPULE should be used with caution in elderly patients (aged above 65 years). Consult your doctor before using COMBIMIST L RESPULE.
Drug Interactions
SA. Drug-Drug interactions: Before using COMBIMIST L RESPULE, inform your doctor if you are taking any of the following medicine: short acting bronchodilators (used to quickly relieve/stop sudden asthma symptoms) Ex. albuterol, levalbuterol medicines used to manage high blood pressure such as beta-adregenic/receptor blocking agents (Ex. propanolol, metoprolol, atenolol) diuretics (used to manage high blood pressure) Ex. chlorothiazide, chlorthalidone digoxin (used to manage irregular heartbeats) monoamine oxidase inhibitors/tricyclic antidepressants (medicines used to manage depression) Ex. selegiline, phenelzine, amitriptyline, imipramine anticholinergic agents (medicines used to block acetylcholine) Ex. atropine, benztropine Overdosage: If you or anyone else accidentally take too much of COMBIMIST L RESPULE, then consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are seizures, chest pain, high/low blood pressure, fast heartbeat, irregular heartbeat, nervousness, headache, tremor, dry mouth, pounding heartbeat, nausea, dizziness, fatigue, weakness, sleeplessness, hypokalaemia (low potassium level in blood), fast breathing, high fever, restlessness, hallucinations, confusion, and/or cardia arrest. SYNOPSIS Drug : Ipratropium bromide, Levosalbutamol Pharmacological Category : Bronchodilator agents, Adrenergic beta-agonists Therapeutic Indication : Bronchospasm associated with chronic pulmonary disease Dosage Forms : Rotacap, Inhalation Capsule, Inhaler, Respules, Smartule, Mistpules, Transpule MORE INFORMATION Keep COMBIMIST L RESPULE out of reach of children Store COMBIMIST L RESPULE above 25°C
Article Information
Written By
DETAILS Written By Dr. K .AZEEM HUSSAIN
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
28 Nov 2022