Cilamin 250mg Capsule 10'S
Key Information
Generic Name
Generic Name Penicillamine 250 mg
Manufacturer
Mankind Pharma Pvt Ltd
Variant
10 Capsule(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
INTRODUCTIONCILAMIN 250MG contains Penicillamine which belongs to the group of medicines called Disease Modifying Anti-rheumatic Drugs (DMARDS). It is used to provide relief from the symptoms of rheumatoid arthritis (joint pain), including Still’s disease in both adults and in children when other medicines have not worked adequately. Due to its chelating property, it is also indicated for the management of Wilson’s disease (a genetic disorder characterized by accumulation of copper in the liver causing local degeneration), lead poisoning and cystinuria (presence of cysteine stones in the kidneys, ureter or bladders) in both adults and in children. It can also be used to manage chronic active hepatitis (a type of liver disease caused by copper accumulation) in adult patients. Penicillamine acts by increasing the renal excretion of copper, lead and cysteine. It also suppresses body’s immune response and helps in reducing inflammation, pain and stiffness caused by rheumatoid arthritis. It promotes liver detoxification and protects your liver from further damage. Before and during management with CILAMIN 250MG, your doctor will ask you to take several blood test and urine test in order to monitor your blood count and kidney function, so that he can adjust your dose and prevent you from any unwanted
Uses
OF CILAMIN 250MG Manages Wilson’s disease, cystinuria, lead poisoning and rheumatoid arthritis in both adults and in children Manages chronic active hepatitis in adults
How It Works
Penicillamine is a chelating agent. It effectively chelates heavy metals such as copper and lead and promotes the excretion of these metals in urine. It also forms a soluble complex with cysteine which helps in the dissolution of cysteine calculi present in the kidneys, ureters or bladder. In rheumatoid arthritis, it acts by depressing the activity of T-lymphocytes and by increasing the levels of soluble collagen which reduces pain, stiffness, inflammation and swelling. In chronic hepatitis, it acts by enhancing liver detoxification and protects your liver from further damage.
Directions for Use
Take CILAMIN 250MG as directed by your physician. It must be taken on an empty stomach either one hour before or two hours after meals. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Avoid consumption of milk while taking this medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Side Effects
this medicine with iron products, antacids or digoxin as it may reduce its effectiveness. The most common side effects of taking this medicine are unusual bleeding and protein in your urine. Before taking this medicine, inform your doctor if you have any blood problems. CILAMIN 250MG is highly contraindicated for use in patients having kidney disease and in pregnant and breastfeeding women. It should be used with caution in children and adolescents under 18 years of age. Suitable dose titration and careful monitoring are required in such patients. USES OF CILAMIN 250MG Manages Wilson’s disease, cystinuria, lead poisoning and rheumatoid arthritis in both adults and in children Manages chronic active hepatitis in adults HOW CILAMIN 250MG WORKSPenicillamine is a chelating agent. It effectively chelates heavy metals such as copper and lead and promotes the excretion of these metals in urine. It also forms a soluble complex with cysteine which helps in the dissolution of cysteine calculi present in the kidneys, ureters or bladder. In rheumatoid arthritis, it acts by depressing the activity of T-lymphocytes and by increasing the levels of soluble collagen which reduces pain, stiffness, inflammation and swelling. In chronic hepatitis, it acts by enhancing liver detoxification and protects your liver from further damage. DIRECTIONS FOR USETake CILAMIN 250MG as directed by your physician. It must be taken on an empty stomach either one hour before or two hours after meals. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Avoid consumption of milk while taking this medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. SIDE EFFECTS OF CILAMIN 250MGSERIOUS allergic reaction (such as skin rash, itching, sudden swelling, difficulty in breathing, chest pain or fever) signs of thrombocytopenia (bruising easily, nose bleeds or bleeding gums) blood in urine signs of anemia (feeling tired or weak and paleness of the skin) COMMON proteinuria (protein in urine) RARE mouth ulcers or soreness swollen breast tissue hair loss wrinkles in the skin clusters of the small reddish bumps usually on the neck or arms
Warnings & Precautions
& PRECAUTIONSPREGNANCYCILAMIN 250MG is not recommended for use in pregnant women unless necessary. Consult your doctor for advice before taking. BREASTFEEDINGCILAMIN 250MG is not recommended for use in breastfeeding women unless necessary. Consult your doctor for advice before taking. DRIVING AND USING MACHINESDo not drive or operate any machines if your ability is affected by this medicine. KIDNEYCILAMIN 250MG is not recommended for use in patients with severe kidney disease. Consult your doctor for advice before taking. ALLERGYDo not take this medicine if you are allergic to penicillamine. OTHERSBefore taking CILAMIN 250MG, inform your doctor if you: have Goodpasture's syndrome (bleeding from the lungs, glomerulonephritis and kidney failure) have myasthenia gravis (muscle weakness) have proteinuria (protein in urine) have blood in your urine have leucopenia (low white blood cells) are elderly (aged above 65 years)
Drug Interactions
STalk to your doctor, if you are taking, gold-therapy products (used to manage rheumatoid arthritis) such as aurothioglucose, auranofin or gold sodium thiomalate) non-steroidal anti-inflammatory drugs (e.g. naproxen, phenylbutazone or ibuprofen) clozapine (a medicine used to manage schizophrenia) medicines used to manage anemia (e.g. iron supplements) antacids (used to neutralize stomach acid) e.g. aluminium hydroxide, magnesium hydroxide medicines used to manage malaria (e.g. mefloquine, quinine, chloroquine, hydroxychloroquine, primaquine, or pyrimethamine) medicines used to manage cancer (e.g. methotrexate, doxorubicin) digoxin (used to manage irregular heartbeat) SYNOPSIS Drug : Penicillamine Pharmacological Category : Chelating agent, Disease Modifying Anti-rheumatic drugs Therapeutic Indication : Wilson’s disease, Cystinuria, Rheumatoid arthritis, Lead poisoning Dosage Forms : Hard gelatin capsule MORE INFORMATIONStore below 20-25°C and keep out of reach of children.