Borviz 2.5Mg Injection 1's
Key Information
Generic Name
Generic Name Bortezomib 2.5 mg
Manufacturer
Intas Pharmaceuticals Ltd
Country of Origin
India
Detailed Information
Introduction
INTRODUCTION ABOUT BORVIZ 2.5MG INJECTIONBORVIZ 2.5MG INJECTION contains Bortezomib, which belongs to the group of medicines called Antineoplastic agents. It is used in adult patients alone or with pegylated liposomal doxorubicin/dexamethasone to manage progressive multiple myeloma when anticancer therapy or hematopoietic stem cell transplantation becomes unsuitable to manage the disease. BORVIZ 2.5MG INJECTION is also used in adult patients with rituximab, cyclophosphamide, doxorubicin, and prednisone to manage unmanageed mantle cell lymphoma when hematopoietic stem cell transplantation becomes unsuitable to manage the disease. Multiple myeloma is a type of cancer that occurs in plasma cells (white blood cells) and is generally characterized by symptoms such as bone pain, nausea, constipation, and loss of appetite. Mantle Cell Lymphoma is a rare form of cancer that affects the lymphatic system and is generally characterized by symptoms such as loss of appetite, fever, nausea, and/or vomiting. Your doctor may advise you to do regular blood tests to check your blood counts before and during management with BORVIZ 2.5MG INJECTION. It is not recommended for use in patients with severe lung or heart disease. Before receiving BORVIZ 2.5MG INJECTION, inform your doctor if you have bleeding problems, diarrhea, constipation, nausea or vomiting, shortness of breath or cough, seizures, congestive heart failure, mild or moderate renal impairment, and/or moderate or severe liver impairment. BORVIZ 2.5MG INJECTION is not recommended for use by pregnant and breastfeeding women. BORVIZ 2.5MG INJECTION is also not indicated for use in children and adolescents (below 18 years of age). The most common
Uses
OF BORVIZ 2.5MG INJECTIONUsed in adults: To manage progressive multiple myeloma when anticancer therapy or hematopoietic stem cell transplantation becomes unsuitable to manage the disease (alone or in combination with pegylated liposomal doxorubicin/dexamethasone) To manage unmanageed mantle cell lymphoma (with rituximab, cyclophosphamide, doxorubicin, and prednisone when hematopoietic stem cell transplantation becomes unsuitable to manage the disease)
How It Works
BORVIZ 2.5MG INJECTION works by inhibiting proteasomes (enzymes responsible for breaking down proteins into smaller compounds for cells), which leads to imbalance in the cancer cell, thus resulting in its destruction and thereby managing multiple myeloma and mantle cell lymphoma in affected individuals.
Directions for Use
BORVIZ 2.5MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or into the skin as a subcutaneous injection. Your doctor will decide the correct dose and duration of BORVIZ 2.5MG INJECTION for you depending upon your age, body weight, and disease condition.
Side Effects
receiving BORVIZ 2.5MG INJECTION are dizziness, increased heartbeat, sweating, abnormal vision, paresthesia (burning or pickling sensation), muscle pain, and headache. Inform your doctor if any of the symptoms worsen during or after management with BORVIZ 2.5MG INJECTION. USES OF BORVIZ 2.5MG INJECTIONUsed in adults: To manage progressive multiple myeloma when anticancer therapy or hematopoietic stem cell transplantation becomes unsuitable to manage the disease (alone or in combination with pegylated liposomal doxorubicin/dexamethasone) To manage unmanageed mantle cell lymphoma (with rituximab, cyclophosphamide, doxorubicin, and prednisone when hematopoietic stem cell transplantation becomes unsuitable to manage the disease) HOW BORVIZ 2.5MG INJECTION WORKSBORVIZ 2.5MG INJECTION works by inhibiting proteasomes (enzymes responsible for breaking down proteins into smaller compounds for cells), which leads to imbalance in the cancer cell, thus resulting in its destruction and thereby managing multiple myeloma and mantle cell lymphoma in affected individuals. DIRECTIONS FOR USEBORVIZ 2.5MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or into the skin as a subcutaneous injection. Your doctor will decide the correct dose and duration of BORVIZ 2.5MG INJECTION for you depending upon your age, body weight, and disease condition. SIDE EFFECTS OF BORVIZ 2.5MG INJECTIONCOMMON fluid retention difficulty or problems sleeping altered level of consciousness, confusion dizziness, abnormal vision chest discomfort and sweating cough, hiccups ringing in the ears, ear discomfort difficulty swallowing infection or inflammation of the stomach and intestine throat pain, decreased appetite infection of the urinary tract pain in limbs, numbness, fever burning or pickling sensation nausea or vomiting constipation with or without bloating (can be severe) diarrhea tiredness, weakness muscle or bone pain low or high blood pressure sudden fall of blood pressure while standing, which may lead to fainting headache general ill feeling, pain vertigo (spinning sensation), light-headedness shivering chest pain or shortness of breath with exercise itching of the skin lumps on the skin or dry skin facial blushing or tiny broken capillaries redness of the skin dehydration heartburn, bloating, belching, wind, stomach pain, bleeding from your bowels or stomach sore mouth or lip, dry mouth, mouth ulcers weight loss loss of taste muscle cramps, muscle spasms, muscle weakness, and pain in your limbs blurred vision nose bleeds hair loss and abnormal hair texture UNCOMMON inflammation of a vein and blood clots in your veins and lungs problems with blood clotting insufficient circulation inflammation of the lining around your heart or fluid around your heart bloody stools or bleeding from mucosal membranes such as the mouth or vagina cerebrovascular disorders speech disorders memory impairment or loss hearing loss, deafness or ringing in the ears, ear discomfort hormone abnormality that may affect salt and water absorption overactive thyroid gland swelling of your lymph glands joint or muscle stiffness, sense of heaviness, pain in your groin redness or pain at the injection site mouth pain skin or tooth infection genital pain, problem having an erection weight increase, thirst hepatitis, sepsis skin reactions and disorders (which may be severe and life-threatening), skin ulcers bruises, falls, and injuries RARE serious nerve inflammation, which may cause paralysis and difficulty breathing flushing discoloration of the veins inflammation of the spinal nerve ear problems such as bleeding from the ear underactivity of the thyroid gland abnormal bowel function signs of bleeding in the brain, such as headache and confusion yellow discoloration of the eyes and skin (jaundice) breast disorders vaginal tears loss of body mass, fistula joint effusion, fracture kidney cancer skin conditions such as psoriasis (itching) and skin cancer abnormal reaction to blood transfusions partial or total loss of vision, drooling decreased sex drive bulging eyes hernia, gallstones, rectal pain brittle/weak nails intestinal ulcers multi-organ failure Stop receiving BORVIZ 2.5MG INJECTION and contact your doctor immediately if you experience any of the following side effects: meningitis, Epstein-Barr virus infection, genital herpes tonsillitis, mastoiditis post-viral fatigue syndrome grade 4 neuropathy (life-threatening damage or dysfunction of one or more nerves) and/or severe autonomic neuropathy (nerve damage that controls automatic body functions) signs of progressive multifocal leukoencephalopathy (neurological disorder) such as clumsiness or loss of coordination, difficulty walking, and facial drooping signs of posterior reversible encephalopathy syndrome (a rare rapidly evolving neurological disorder) such as seizure, hypertension, headache, lethargy, confusion, blindness signs of peripheral neuropathy (nerve damage that occurs in hands and feet) such as gradual onset of numbness, prickling or tingling in feet or hands, sharp, jabbing, throbbing, or burning pain, and extreme sensitivity to touch cardiac failure signs of tumor lysis syndrome (a condition that occurs when tumor cells release their contents into the bloodstream), such as nausea with or without vomiting, lack of appetite, weakness, and dark urine signs of pulmonary hypertension (type of high blood pressure that affects arteries in the lungs and in the heart) such as blue lips and skin, chest pressure or pain, and dizziness acute diffuse infiltrative pulmonary disorders (group of lung disorders) such as shortness of breath, coughing (typically nonproductive), decreased exercise tolerance, and weakness signs of Guillain-Barre syndrome (serious nerve inflammation) such as paralysis and difficulty breathing signs of allergy, such as a serum-sickness-type reaction signs of polyarthritis (a type of joint disease that involves at least five joints) such as pain, stiffness, swelling or redness in the affected area, or rash signs of auto-immune disorders such as proliferative glomerulonephritis
Warnings & Precautions
& PRECAUTIONSPREGNANCYConsult your doctorBORVIZ 2.5MG INJECTION is not recommended for use during pregnancy or by women planning for pregnancy. It should be used with caution in women with childbearing potential who should use effective contraceptive measures before receiving BORVIZ 2.5MG INJECTION. BREASTFEEDINGContraindicatedBORVIZ 2.5MG INJECTION is not recommended for use by breastfeeding women. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. DRIVING AND USING MACHINESUse with CautionDo not drive or operate any machines if you feel dizzy, tired, syncope (fainting), and/or blurred vision after receiving BORVIZ 2.5MG INJECTION. KIDNEYUse with CautionBORVIZ 2.5MG INJECTION should be used with caution in patients with kidney problems such as mild to moderate renal impairment. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. LIVERUse with CautionBORVIZ 2.5MG INJECTION should be used with caution in patients with moderate or severe liver problems, such as hepatic impairment. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. ALLERGYContraindicatedDo not receive BORVIZ 2.5MG INJECTION if you are allergic to bortezomib, boron, or any other ingredients of this medicine. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. LUNGSConsult your doctorBORVIZ 2.5MG INJECTION is not recommended for use in patients with severe lung problems. It should be used with caution in patients with hepatitis B virus disease. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. HEART DISEASEConsult your doctorBORVIZ 2.5MG INJECTION is not recommended for use if you have severe heart problems. BORVIZ 2.5MG INJECTION should be used with caution in patients suffering from heart problems such as congestive heart failure. Consult your doctor before receiving BORVIZ 2.5MG INJECTION. USE IN PEDIATRICSContraindicatedBORVIZ 2.5MG INJECTION is generally not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice before administering BORVIZ 2.5MG INJECTION to your child. USE IN GERIATRICSUse with CautionBORVIZ 2.5MG INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving BORVIZ 2.5MG INJECTION. OTHERSBefore receiving BORVIZ 2.5MG INJECTION, inform your doctor if you have: low red or white blood cell count bleeding problems and/or a low number of platelets in your blood diarrhea, constipation, nausea, or vomiting fainting, dizziness, or light-headedness in the past numbness, tingling, or pain in the hands or feet (neuropathy) in the past blood pressure problems shortness of breath or cough seizures shingles (a viral infection that causes swelling around the eyes or spreads across the body) symptoms of tumor lysis syndrome such as muscle cramping, muscle weakness, confusion, visual loss or disturbances, and shortness of breath signs of a serious brain infection such as memory loss, trouble thinking, difficulty walking, or loss of vision muscle cramping, muscle weakness confusion, visual loss or disturbances, blindness, seizures, headaches shortness of breath, swelling of your feet or changes in your heartbeat, high blood pressure, tiredness, or fainting coughing and breathing difficulties or tightness in the chest
Drug Interactions
SA. Drug-Drug interactions: Before taking BORVIZ 2.5MG INJECTION, inform your doctor if you are taking any of the following medicines: ketoconazole (used to manage fungal infections) omeprazole (used to manage indigestion and heartburn) dexamethasone (used to manage inflammation and severe allergies) melphalan, prednisone (used to manage multiple myeloma) ritonavir (used to manage HIV infection) rifampicin (an antibiotic used to manage bacterial infections) carbamazepine, phenytoin, or phenobarbital (used to manage epilepsy) St. John’s wort (herbal medicine used to manage depression) oral antidiabetics (used to manage diabetes) Ex. metformin, glimepiride adalimumab (used to manage pain and swelling due to arthritis) lomitapide (used to manage cholesterol levels) Overdosage: BORVIZ 2.5MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so you are unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms of BORVIZ 2.5MG INJECTION, such as the acute onset of symptomatic hypotension (low blood pressure while standing up from a lying position) and thrombocytopenia (a condition marked by a low platelet count). SYNOPSIS Drug : Bortezomib Pharmacological Category : Anti-neoplastic agent Therapeutic Indication : Multiple myeloma, Mantle cell Lymphoma Dosage Forms : Injection MORE INFORMATION Store BORVIZ 2.5MG INJECTION in a refrigerator at 2-8°C
Frequently Asked Questions
Common questions and answers about Borviz 2.5Mg Injection 1's.
How is BORVIZ 2.5MG INJECTION administered?
BORVIZ 2.5MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or into the skin as a subcutaneous injection. Your doctor will decide the correct dose and duration of BORVIZ 2.5MG INJECTION for you depending upon your age, body weight, and disease condition.
Can BORVIZ 2.5MG INJECTION be used during pregnancy?
BORVIZ 2.5MG INJECTION is not recommended for use during pregnancy or by women planning for pregnancy. It should be used with caution in women with childbearing potential who should use effective contraceptive measures before receiving BORVIZ 2.5MG INJECTION.
Who should avoid receiving BORVIZ 2.5MG INJECTION?
BORVIZ 2.5MG INJECTION is not recommended for use in patients with severe lung and liver problems, and it is also not recommended for use in pregnant and breastfeeding women. BORVIZ 2.5MG INJECTION is also not indicated for use in children and adolescents (below 18 years of age). Consult your doctor before receiving BORVIZ 2.5MG INJECTION.
Can I drive after receiving BORVIZ 2.5MG INJECTION?
Do not drive after receiving BORVIZ 2.5MG INJECTION since it may cause dizziness, tiredness, syncope (fainting), and/or blurred vision, which may affect your ability or concentration to drive. Consult your doctor before receiving BORVIZ 2.5MG INJECTION.
Can BORVIZ 2.5MG INJECTION be used in patients with liver problems?
BORVIZ 2.5MG INJECTION should be used with caution in patients with moderate or severe liver problems, such as hepatic impairment. Consult your doctor before receiving BORVIZ 2.5MG INJECTION.
Article Information
Written By
DETAILS Written By Dr. N. Sai Swaroop
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
02 Dec 2023