Amnurite P Tablet 10'S
Key Information
Generic Name
Generic Name Amitriptyline 10 mg+Pregabalin 75 mg
Manufacturer
Centaur Pharmaceuticals Pvt Ltd
Variant
10 Tablet(s) in a Strip
Country of Origin
India
Detailed Information
Introduction
AMNURITE P TABLET is a combination of Amitriptyline and Pregabalin which belongs to the group of medicine called Antidepressants and Anti-epileptics respectively. It is used to manage pain caused due to nerve damage. It is indicated in the management of peripheral neuropathies (nerve pain in peripheral parts of the body such as hands and legs), diabetic neuropathy (nerve damage caused due to diabetes), trigeminal neuralgia (painful conditions of the face). Also, it is used to manage post herpetic neuralgia (pain caused due to damage of nerve fibers of skin that occurs after the disappearance of skin rash and blisters (shingles)) and chronic lower back pain or spondylitis (pain and inflammation of spinal bones). It can also be used to manage neuritis (inflammation in the peripheral nerves) and radiculopathy (pain, weakness, tingling, and numbness caused to pinching or damage of nerve roots). AMNURITE P TABLET can be used along with pioglitazone to reduce nerve damage among diabetic patients. During the therapy, your doctor would closely monitor your health condition to avoid the risk of
Uses
OF AMNURITE P TABLETManages pain in the following conditions such as: peripheral neuropathies (nerve pain in hands and legs) diabetic neuropathy (nerve pain due to diabetes) trigeminal neuralgia (pain in face) post herpetic neuralgia (pain due to damaged nerve fibers of skin) chronic lower back pain, spondylitis neuritis (nerve inflammation) radiculopathy (damages in nerve roots arising from spinal cord)
How It Works
AMNURITE P TABLET effectively reduces nerve damage and pain where pregabalin acts by altering the activity of calcium channels of nerve cells and amitriptyline acts by blocking the movement of certain chemical messengers (such as serotonin, noradrenaline, and dopamine) between the nerve cells which are involved in causing pain and inflammation. Together, they stop the transmission of pain signals across the brain and spinal cord and provides relief from pain.
Directions for Use
Take AMNURITE P TABLET as advised by your physician. Swallow AMNURITE P TABLET with a glass of water. Do not crush or chew [GBNKRYWORD]. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking AMNURITE P TABLET abruptly without consulting your doctor as it may lead to withdrawal symptoms such as difficulty in falling asleep, headache, nausea, anxiety, diarrhoea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating and dizziness.
Side Effects
therapy, therefore consult your doctor immediately if you or anyone else experience such thoughts. The most common side effects of taking AMNURITE P TABLET are dizziness, headache, nausea, vomiting, dry mouth, bloating and altered taste sensation. Consult your doctor if any of the symptoms worsen. USES OF AMNURITE P TABLETManages pain in the following conditions such as: peripheral neuropathies (nerve pain in hands and legs) diabetic neuropathy (nerve pain due to diabetes) trigeminal neuralgia (pain in face) post herpetic neuralgia (pain due to damaged nerve fibers of skin) chronic lower back pain, spondylitis neuritis (nerve inflammation) radiculopathy (damages in nerve roots arising from spinal cord) HOW AMNURITE P TABLET WORKSAMNURITE P TABLET effectively reduces nerve damage and pain where pregabalin acts by altering the activity of calcium channels of nerve cells and amitriptyline acts by blocking the movement of certain chemical messengers (such as serotonin, noradrenaline, and dopamine) between the nerve cells which are involved in causing pain and inflammation. Together, they stop the transmission of pain signals across the brain and spinal cord and provides relief from pain. DIRECTIONS FOR USETake AMNURITE P TABLET as advised by your physician. Swallow AMNURITE P TABLET with a glass of water. Do not crush or chew [GBNKRYWORD]. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking AMNURITE P TABLET abruptly without consulting your doctor as it may lead to withdrawal symptoms such as difficulty in falling asleep, headache, nausea, anxiety, diarrhoea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating and dizziness. SIDE EFFECTS OF AMNURITE P TABLETCOMMON dizziness, drowsiness, headache feeling dizzy while standing up (orthostatic hypertension) increased hunger or thirst feeling high or excited feeling shaky, confused, irritated or disoriented decreased sexual interest, difficulty in erection, delayed ejaculation difficulty in concentration, memory impairment, difficulty in speaking clumsiness or abnormal walking sense of tingling or numbness severe weakness or tiredness blurred vision or double vision vertigo (spinning sensation) problem in balance dryness of mouth nausea or vomiting bloating, diarrhoea edema (swelling of body including extremities) weight gain muscle cramps, joint pain, back pain, pain in limbs sore throat abnormal heartbeat increased sweating nose block changes in taste UNCOMMON ringing in the ears (tinnitus) increased production of breast milk without breast feeding increased pressure in eyes which may lead to weak eye or dry eyes weight loss restlessness, depression, agitation, mood swings, hallucinations, nightmares panic attacks unusual eye movements, pain and swelling of the eye, watery eyes increased sensitivity of skin to light, hot flushes difficulty in breathing, dry nose increased saliva production heartburn or numbness around the mouth and lips neck pain, breast pain painful menstrual periods coldness of hands and feet RARE hair loss breast enlargement in men changes in the sense of smell inflammation of the pancreas (nausea, vomiting, upper stomach pain and tenderness) parkinsonism (such as tremor, decreased ability to move, and muscle stiffness) Stop taking AMNURITE P TABLET and contact your doctor immediately if you experience any of the following side effects: signs of a severe allergic reaction (skin rash with blisters and peeling, swelling of the eye, throat or tongue which leads to difficulty in breathing) sudden attacks of intermittent blurring of vision, rainbow vision with eye pain signs of prolonged QT interval (sudden fainting, dizziness, abnormal heart rate) signs of intestine paralysis (such as severe constipation, swollen stomach, fever, and vomiting) jaundice (yellowing of skin and whites of eyes) signs of abnormal blood counts (such as bruising, bleeding, looking pale, or persistent sore throat and fever) suicidal thoughts or behavior signs of mania (feeling extreme happiness, increased physical activity, profuse and rapidly changing thoughts, and ideas) decrease in urine output convulsions
Warnings & Precautions
& PRECAUTIONSPREGNANCYAMNURITE P TABLET is generally not recommended for use in pregnant women unless it is considered necessary by the physician. Consult your doctor before taking it. BREASTFEEDINGAMNURITE P TABLET is not generally recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it. DRIVING AND USING MACHINESDo not drive or operate any heavy tools or machines after taking AMNURITE P TABLET as it may cause dizziness and sleepiness. ALCOHOLAvoid consumption of alcohol while taking AMNURITE P TABLET, as it may enhance the effect of alcohol. KIDNEYAMNURITE P TABLET is not recommended for use in patients with a history of urinary retention (difficulty in passing urine). It should be used with caution in patients with renal failure. Consult your doctor before taking AMNURITE P TABLET. LIVERAMNURITE P TABLET is not recommended for use in patients who have impaired liver function. It should be used with caution among patients who have any previous history of liver impairment or liver damage. Consult your doctor before taking AMNURITE P TABLET. ALLERGYDo not take AMNURITE P TABLET if you are allergic to Amitriptyline or Pregabalin. HEART DISEASEAMNURITE P TABLET should be taken with caution in patients with heart diseases (such as myocardial infarction and congestive heart failure). Consult your doctor before taking AMNURITE P TABLET. OTHERSAMNURITE P TABLET is not recommended for use if you: have an enlarged prostate (Ex. Benign Prostatic Hypertrophy) rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption Before taking AMNURITE P TABLET, inform your physician if you: have a history of seizures (fits) have a history of blood dyscrasias (a type of blood disorder) have narrow-angle glaucoma (increased pressure in the eye) have increased activity of thyroid gland are due to have a surgery Use in pediatrics: AMNURITE P TABLET should be used with caution in children and adolescents (aged below 18 years). Consult your child’s doctor for advice. Use in geriatrics: AMNURITE P TABLET should be used with caution in elderly patients due to increased risk of adverse reactions. Your doctor may initiate the management with the lowest effective dose. Consult your doctor before taking AMNURITE P TABLET.
Drug Interactions
SA. Drug-Drug interactions: Before taking AMNURITE P TABLET, inform your doctor if you are taking any of the following medicines: monoamine oxidase inhibitors (used to manage depression) Ex. sertraline, isocarboxazid, phenelzine or tranylcypromine medicines used to manage overactivity of thyroid gland (Ex. carbimazole) guanethidine (used to manage high blood pressure) sympathomimetic drugs (medicines which are used to decrease heartbeat, increase in body secretions, and muscle movements) Ex. adrenaline local anesthetics (used to cause numbness of a particular region) Ex. lignocaine cimetidine (used to manage stomach ulcers) ethchlorvynol (a medicine used to induce sleep) medicines that can reduce anxiety and induce sleep (Ex. phenobarbital, clonazepam) disulfiram (used to manage alcohol addiction) neuroleptic drugs (used to manage epilepsy) Ex. phenytoin, carbamazepine, valproic acid neomycin (used to manage bacterial infections) mesalamine (used to manage irritable bowel syndrome) colchicine (used to manage gout) Overdosage: If you or anyone else accidentally take too much of AMNURITE P TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include decrease or increase in body temperature, confusion, difficulty in concentration, hallucinations, drowsiness, fast heart rate, heart failure, dilation of pupil, convulsions, eye problems such as cannot move eyes, severe low blood pressure, loss of consciousness, constipation, shaking, muscle tightness, vomiting, weakness, depression and restlessness. SYNOPSIS Drug : Amitriptyline, Pregabalin Pharmacological Category : Tricyclic Antidepressants, Gamma-aminobutyric acid analogs Therapeutic Indication : Nerve pain relief Dosage Forms : Tablet MORE INFORMATION Keep AMNURITE P TABLET out of reach of children Store at room temperature
Article Information
Written By
DETAILS Written By Dr. R. Dinesh John Rajkumar
Medical Content Writer
Reviewed By
Dr. Sankara Babu Gorle
Medical Expert
Last Updated
14 Dec 2022